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Preparation method of calcium hydroxytitanate fiber coating on the surface of titanium-based implant with complex morphology

A technology of calcium hydroxy titanate and implants, applied in coatings, metal material coating processes, pharmaceutical formulations, etc., can solve the problems of lack of biological activity, long healing time, and low bonding strength, and achieve simple ingredients and low production costs The effect of low and high bond strength

Active Publication Date: 2022-02-18
XI AN JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0002] Titanium and titanium alloys are commonly used materials for dental implants and load-bearing bone implants. They have good strength and toughness, but lack biological activity. They cannot form chemical bonds with bone in the early stage of implantation and the healing time is long. Surface treatment is required. bioactivation modification
At present, hydroxyapatite and bioactive glass are mostly used as coating materials for bioactivation on the surface of titanium alloys. Titanium dioxide or sodium titanate gel films formed by chemical activation of titanium alloys have been used as bioactivation surfaces. These coatings Both the titanium alloy and the thin film have obvious interfaces and low bonding strength; the titanium oxide layer enriched in calcium and phosphorus formed on the surface of the titanium alloy by ion beam implantation has also been proved to be biologically active, but this technology is not effective on complex surfaces such as threaded The surface of dental implants is difficult to implement; the currently researched micro-arc oxidation bioactive modification technology is a two-step method of "micro-arc oxidation + subsequent hydrothermal treatment", and the structural characteristics of the obtained bioactive surface layer are "titanium oxide layer + hydroxyl phosphorus "Greystone layer" double-layer structure, and this technology is also difficult to implement on complex surfaces

Method used

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  • Preparation method of calcium hydroxytitanate fiber coating on the surface of titanium-based implant with complex morphology
  • Preparation method of calcium hydroxytitanate fiber coating on the surface of titanium-based implant with complex morphology
  • Preparation method of calcium hydroxytitanate fiber coating on the surface of titanium-based implant with complex morphology

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preparation example Construction

[0045] A method for preparing a calcium hydroxytitanate fiber coating on the surface of a titanium-based implant with a complex shape, comprising the following steps:

[0046] 1) Mechanical polishing

[0047] Using pure titanium sheet as the base material, the surface of the metal sample is polished and smooth with 100#, 400#, 800#, 1500# metallographic sandpaper in sequence, and then ultrasonically cleaned with acetone, absolute ethanol and deionized water for 10~ 20min, dry for later use.

[0048] 2) Etching

[0049] Prepare the etching solution, the ratio is, the volume ratio of nitric acid solution: hydrofluoric acid solution: deionized water is 1:1:8, the mass fraction of the nitric acid solution is 69.2%, and the mass fraction of the hydrofluoric acid solution is 40% %, put the mechanically polished titanium sheet into the etching solution to etch for 20-30s, wash it three times with deionized water, and ultrasonically clean it with deionized water for 20-30s, and dry ...

Embodiment 1

[0058] First, the titanium sheet is mechanically polished, and the surface of the titanium sheet is polished and smooth with 100#, 400#, 800#, and 1500# metallographic sandpaper in sequence, and then ultrasonically cleaned with acetone, absolute ethanol, and deionized water for 20 minutes, and dried Ready to use, the surface morphology of the titanium sheet is as follows Figure 12 (a) shown. The mechanically polished titanium sheet was etched in the etching solution for 30s, washed three times with deionized water, and ultrasonically cleaned with deionized water for 30s, and dried for use. The surface appearance of the titanium sheet was as follows: Figure 12 (b) shown. Set the concentration to 1.0mol·L -1 The NaOH solution was injected into the hydrothermal reaction kettle, and the filling degree of the solution was 33%, and the pure titanium sample treated according to the above process was soaked in the solution, and it was hydrothermally treated at 220°C for 2 hours, a...

Embodiment 2

[0060] First, the titanium sheet is mechanically polished, and the surface of the titanium sheet is polished and smooth with 100#, 400#, 800#, and 1500# metallographic sandpaper in sequence, and then ultrasonically cleaned with acetone, absolute ethanol, and deionized water for 15 minutes, and then dried stand-by. The mechanically polished titanium sheet was etched in an etching solution for 25 s, washed three times with deionized water, ultrasonically cleaned with deionized water for 25 s, and dried for use. Set the concentration to 1.0mol·L -1 The NaOH solution was injected into the hydrothermal reaction kettle, and the filling degree of the solution was 33%, and the pure titanium sample treated according to the above process was soaked in the solution, and it was hydrothermally treated at 220°C for 5 hours, and the sample was taken out and Rinse with deionized water and dry for use, and complete a hydrothermal treatment process; the concentration is 0.5mol L -1 CaCl 2 Th...

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Abstract

The invention discloses a method for preparing a calcium hydroxy titanate fiber coating on the surface of a titanium-based implant with a complex shape. Pure titanium sheets are used as a base material, and after the surface is polished smooth, it is cleaned and dried for use; an etching solution is prepared, Put the polished titanium sheet into the etching solution to etch, then wash and dry it for use; soak the obtained pure titanium sample in NaOH solution, and perform a hydrothermal treatment to obtain a hydrothermal sample; Hot samples soaked in CaCl 2 In the solution, a secondary hydrothermal treatment is carried out, that is, a complex morphology titanium-based medical implant calcium hydroxytitanate bioactive coating is obtained on the titanium surface. The present invention realizes the construction of three-dimensional nanofiber coatings with different geometric configurations on the surface of titanium implants through a simple and easy two-step hydrothermal method, and the construction of the coatings on each surface immersed in the solution is uniform, without dead ends and The site can be covered, and a gradient 3D coating can be obtained through the combined action of liquid and gas, which can be used to make special bone nails that penetrate cortical bone and cancellous bone.

Description

technical field [0001] The invention belongs to the technical field of titanium-based surface treatment, and in particular relates to a preparation method for a titanium-based calcium-hydroxytitanate fiber coating on the surface of a complex-shaped titanium-based implant. Background technique [0002] Titanium and titanium alloys are commonly used materials for dental implants and load-bearing bone implants. They have good strength and toughness, but lack biological activity. They cannot form chemical bonds with bone in the early stage of implantation and the healing time is long. bioactivation modification. At present, hydroxyapatite and bioactive glass are mostly used as coating materials for bioactivation on the surface of titanium alloys. Titanium dioxide or sodium titanate gel films formed by chemical activation of titanium alloys have been used as bioactivation surfaces. These coatings Both the titanium alloy and the thin film have obvious interfaces and low bonding s...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L31/02A61L31/08A61L31/14A61L31/16C23C18/12
CPCA61L31/022A61L31/088A61L31/14A61L31/16A61L31/146A61L31/086C23C18/1204A61L2400/12A61L2300/112A61L2300/412A61L2300/606
Inventor 憨勇王宏
Owner XI AN JIAOTONG UNIV
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