Check patentability & draft patents in minutes with Patsnap Eureka AI!

Anticoagulation and calcification-resistant artificial heart valve material and preparation method and application thereof

An artificial heart valve and heart valve technology, which are applied in the field of biomedical materials to achieve the effects of less damage, good rejection and anti-adhesion, and good biological safety.

Active Publication Date: 2021-01-26
JILIN VENUS HAOYUE MEDICAL LTD
View PDF4 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no artificial heart valve material that can well overcome the thrombogenicity of biological valves and has a good anti-calcification effect.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Anticoagulation and calcification-resistant artificial heart valve material and preparation method and application thereof
  • Anticoagulation and calcification-resistant artificial heart valve material and preparation method and application thereof
  • Anticoagulation and calcification-resistant artificial heart valve material and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Specific steps are as follows:

[0035] a. Immerse a 10cm*10cm porcine pericardium cross-linked with 0.625v% glutaraldehyde in 100 ml of 10v% trifluoroacetamide solution for 24 hours;

[0036] b. Add 10 ml of perfluorodecalin lubricant for 24 hours;

[0037] c. Preserve with 25% isopropanol aqueous solution after rinsing.

Embodiment 2

[0039] Specific steps are as follows:

[0040] a. Immerse 10cm*10cm porcine pericardium cross-linked with 0.625v% glutaraldehyde in 100 ml of 10v% 2,2,2-trifluoroethylamine hydrochloride solution for 24 hours;

[0041] b. Add 10 ml of pentafluorophenol diethyltrimethylenyl ester lubricant for 24 hours;

[0042] c. Preserve with 25% isopropanol aqueous solution after rinsing.

Embodiment 3

[0044] Specific steps are as follows:

[0045] a. Immerse a 10cm*10cm porcine pericardium cross-linked with 0.625v% glutaraldehyde in 100 ml of 10v% 3-(perfluoro-n-octyl)-1,2-propylene oxide solution for 24h;

[0046] b. Add 10 ml of perfluorodecalin lubricant for 24 hours;

[0047] c. Preserve with 25% isopropanol aqueous solution after rinsing.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses an anticoagulation and calcification-resistant artificial heart valve material and a preparation method and application thereof, and belongs to the technical field of biomedical materials. The anticoagulation and calcification-resistant artificial heart valve material comprises a biological heart valve material, a fluoride super-lubrication anticoagulation coating formed bymodifying the biological heart valve material with amino fluoride or epoxy fluoride and a lubricating agent kept in the fluoride super-lubrication anticoagulation coating. The fluoride super-lubrication anticoagulation coating is constructed on the surface of the biological heart valve material, platelet adhesion and whole blood adhesion can be remarkably reduced, the anticoagulation performanceof the material is greatly improved, the thrombus original property of a biological valve is effectively overcome, and meanwhile, the calcification-resistant performance of the material is improved. The preparation method of the valve material is simple, only simple solution soaking or vapor deposition is needed, damage to the animal pericardium biological valve material is small, few extra or residual chemical reagents are introduced, and good biocompatibility of the material can be kept.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and in particular relates to an anticoagulant and anticalcification artificial heart valve material and a preparation method and application thereof. [0002] technical background [0003] Prosthetic valves are vascular implants and therefore need to have good blood compatibility. For the interventional biological heart valve, the blood flow in the heart is fast, and the blood compatibility of the biological valve is relatively good, so the probability of thrombus formation is small, and the interventional biological valve generally does not need to take anticoagulant drugs for a long time. Although bioprosthetic valves have traditionally been considered a good option for anticoagulation, data analyzes in recent years have shown a higher incidence of thrombosis associated with bioprosthetic valves, especially with the advent of transcatheter aortic valve replacement , bioprosthetic v...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61L27/28A61L27/36A61L27/50A61L33/00A61F2/24
CPCA61L27/28A61L27/3625A61L27/3641A61L27/3687A61L27/50A61L33/0041A61F2/24A61F2/2475A61L2400/02A61L2400/18A61L2420/02A61L2430/20
Inventor 雷洋王云兵杨立
Owner JILIN VENUS HAOYUE MEDICAL LTD
Features
  • R&D
  • Intellectual Property
  • Life Sciences
  • Materials
  • Tech Scout
Why Patsnap Eureka
  • Unparalleled Data Quality
  • Higher Quality Content
  • 60% Fewer Hallucinations
Social media
Patsnap Eureka Blog
Learn More

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2025 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com