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Zirconium-niobium alloy tibial plateau prosthesis containing oxide layer and provided with bone trabecula as well as preparation method

A zirconium-niobium alloy and tibial plateau technology is applied in the field of oxide-containing zirconium-niobium alloy tibial plateau prosthesis and its preparation, which can solve the problems of powder failure to obtain good fusion, uneven microstructure and poor mechanical properties, etc. Achieve excellent bone ingrowth, increase the mechanical fit of the prosthesis, and excellent biocompatibility

Pending Publication Date: 2021-02-05
JIASITE HUAJIAN MEDICAL EQUIP (TIANJIN) CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, many years of clinical application have found that bone cement fixation can bring many safety and effectiveness problems: bone cement monomer polymerization releases heat, causing damage to surrounding tissues; if bone cement particles enter the blood or cause high pressure in the medullary cavity during filling, it will cause pulmonary embolism and fat embolism
However, the solid part of 3D printing products is prone to problems such as uneven microstructure and internal defects, and the mechanical properties are not good; the powder in the structure of the trabecular bone is not well sintered, and the mechanical properties are poor.

Method used

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  • Zirconium-niobium alloy tibial plateau prosthesis containing oxide layer and provided with bone trabecula as well as preparation method
  • Zirconium-niobium alloy tibial plateau prosthesis containing oxide layer and provided with bone trabecula as well as preparation method
  • Zirconium-niobium alloy tibial plateau prosthesis containing oxide layer and provided with bone trabecula as well as preparation method

Examples

Experimental program
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Effect test

Embodiment 1

[0055] A method for preparing a zirconium-niobium alloy tibial plateau prosthesis with trabecular bone comprising the following steps:

[0056] 1) Using zirconium-niobium alloy powder as raw material, the first intermediate product of zirconium-niobium alloy tibial plateau prosthesis with trabecular bone and oxide layer is obtained through 3D printing, and the first intermediate product is placed in a hot isostatic pressing furnace , under the protection of helium, raise the temperature to 1250°C, place it at a constant temperature of 180MPa for 3 hours, drop to normal pressure, and take it out with the furnace cooling to below 200°C to obtain the second intermediate product;

[0057] 2) Place the second intermediate product in a programmed cooling box to cool down to -80°C at a rate of 1°C / min, place it at a constant temperature for 10 hours, and take it out of the programmed cooling box; place it in liquid nitrogen for another 16 hours, and adjust the temperature to Room tem...

Embodiment 2

[0071] A method for preparing a zirconium-niobium alloy tibial plateau prosthesis with trabecular bone comprising the following steps:

[0072] 1) Using zirconium-niobium alloy powder as raw material, the first intermediate product of zirconium-niobium alloy tibial plateau prosthesis with trabecular bone and oxide layer is obtained through 3D printing, and the first intermediate product is placed in a hot isostatic pressing furnace , under the protection of helium, raise the temperature to 1325°C, place it at a constant temperature of 160MPa for 2 hours, drop to normal pressure, and take it out with the furnace cooling to below 200°C to obtain the second intermediate product;

[0073] 2) Place the second intermediate product in a programmed cooling box to cool down to -100°C at a rate of 1°C / min, place it at a constant temperature for 7 hours, and take it out of the programmed cooling box; place it in liquid nitrogen for another 24 hours, and adjust the temperature to Room tem...

Embodiment 3

[0087] 1. The preparation method of the zirconium-niobium alloy tibial plateau prosthesis containing oxide layer with trabecular bone, comprising the following steps:

[0088] (1) Using zirconium-niobium alloy powder as the raw material, the first intermediate product of the oxide layer-containing zirconium-niobium alloy tibial plateau prosthesis with bone trabecula is obtained through 3D printing, and the first intermediate product is placed in a thermoisostatic Press the furnace, under the protection of argon, raise the temperature to 1400°C, place it at a constant temperature of 140MPa for 1 hour, drop to normal pressure, and take it out with the furnace cooling to below 200°C to obtain the second intermediate product;

[0089] (2) Place the second intermediate product in a programmed cooling box to cool down to -120°C at a rate of 1°C / min, place it at a constant temperature for 5 hours, and take it out of the programmed cooling box; place it in liquid nitrogen for another 3...

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Abstract

The invention discloses a zirconium-niobium alloy tibial plateau prosthesis containing an oxide layer and provided with bone trabecula as well as a preparation method. According to the method, zirconium-niobium alloy powder is used as a raw material, an intermediate product is obtained through 3D printing integral forming, and then the tibial plateau prosthesis comprising a near-plateau support bone trabecula layer and a far-plateau support bone trabecula layer is prepared through hot isostatic pressing, cryogenic treatment and surface oxidation, the pore diameter and porosity of the near-plateau support bone trabecula layer are uniformly arranged, and the pore diameter and porosity of the far-plateau support bone trabecula layer are arranged in different areas; the bone trabecula topological structure of the tibial plateau prosthesis is in three-dimensional gradient distribution, the micro-strain of 64%-72% of a finite element model is between the lowest effective strain threshold value and the hyper-physiological strain threshold value, the mechanical adaptability of the prosthesis is improved, and the prosthesis has excellent bone ingrowth performance; and the oxide layer of thetibial plateau prosthesis can integrally realize excellent biocompatibility of an osseointegration interface and superhigh wear resistance and low wear rate of a friction interface.

Description

technical field [0001] The invention relates to the technical field of medical implant materials, in particular to a zirconium-niobium alloy tibial platform prosthesis with trabecular bone and a preparation method thereof. Background technique [0002] Total knee arthroplasty is currently an effective clinical treatment for end-stage knee joint diseases. It uses artificially designed joint prostheses to replace damaged knee joint tissue, thereby relieving patients' pain, restoring their knee joint function, and improving their lives. quality. Corresponding to the anatomical structure of the human body, the composition of the knee joint prosthesis includes the femoral condyle, the tibial plateau and the plateau pad. With the rapid development of medical device technology and the continuous improvement of people's requirements for the safety and effectiveness of prosthetic products, the design and manufacturing technology of knee prosthesis will need to be continuously optimi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F2/28A61L27/04A61L27/30A61L27/50A61L27/56B22F5/10B22F10/62B22F10/64B33Y10/00B33Y40/20B33Y70/00C22C16/00C23C8/12
CPCA61F2/28B22F5/10B22F3/00B22F3/15B22F3/24B33Y10/00B33Y40/20B33Y70/00C22C16/00C23C8/12A61L27/047A61L27/50A61L27/56A61L27/306B22F2003/248B22F2003/241A61F2002/2892A61F2002/30985A61F2002/30011A61F2310/00089A61F2310/00095A61L2430/24C23C8/02C23C8/10A61F2/3094A61F2/389A61F2002/30884A61F2002/3092A61L2400/18A61L2430/02B22F7/002B22F7/008B22F10/20B22F10/64C22F1/186B33Y80/00B22F2998/10B22F2999/00B22F10/14Y02P10/25B22F10/28B22F10/66C22C1/0458B22F2202/03B22F2207/17A61L2420/02
Inventor 刘璐曹雨李建宇张景康周红秀
Owner JIASITE HUAJIAN MEDICAL EQUIP (TIANJIN) CO LTD
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