Method for preparing medicine for reducing coupling degree of TRPV4 and NOX2

A drug and coupling technology, applied in the field of chemical medicine, can solve the problems of strong side effects and off-target, and achieve the effect of small side effects, strong targeting, and prevention of thrombosis
CN112336723APending Publication Date: 2021-02-09JIANGNAN UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
JIANGNAN UNIV
Publication Date
2021-02-09

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Abstract

The invention discloses a method for preparing a medicine for reducing a coupling degree of TRPV4 and NOX2, and belongs to the technical field of chemical medicines. According to the invention, entrectinib, L755507, gambogic acid and M12 compounds are used as active ingredients and applied to preparing the medicine for reducing the coupling degree of TRPV4 and NOX2, anti-oxidative stress and vascular permeability, in order to realize a reduced coupling degree in obese patients with excessively coupled TRPV4 and NOX2, so that the two excessively coupled proteins are decoupled, and the normal state is recovered, thus oxidative stress and vascular permeability of the obese patients are recovered to normal levels.
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Description

technical field

[0001] The invention specifically relates to a method for preparing a medicine for reducing the coupling degree of TRPV4 and NOX2, and belongs to the technical field of chemistry and medicine. Background technique

[0002] Reactive oxygen species (ROS) are a series of intermediate products derived from the reduction process of molecular oxygen, mainly including superoxide anion (·O2-), hydrogen peroxide (H2O2), hydroxyl radical (·OH), hypochlorous acid (HOCl ) etc. (Antioxid Redox Signal, 2015, 23, 514-32). Among them, free radicals refer to any substances with unpaired electrons, which are easy to react with healthy molecules. They can be produced in different mechanisms in cells and can proliferate indefinitely in the presence of oxygen. Once these free radicals reach a high Concentrations can cause oxidative damage to tissues or organs (Biomed Res Int, 2014, 831-841). In the mitochondrial respiratory chain, free radicals are produced as by-products of th...

Claims

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