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Low-GI total-nutrient meal replacement powder for intervening polycystic ovarian syndrome based on ketogenesis principle and application of low-GI total-nutrient meal replacement powder

A technology of polycystic ovary and meal replacement powder is applied in the directions of application, active ingredients of hydroxyl compounds, medical raw materials derived from fish feed, etc.

Pending Publication Date: 2021-02-12
JINSHAN HOSPITAL FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is no report about a low-GI full-nutrition meal replacement powder and its application based on the principle of ketogenic intervention in polycystic ovary syndrome of the present invention

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0101] Embodiment 1 meal replacement powder

[0102] Calculated on the basis of 100KG cost meal replacement powder:

[0103] Raw coconut oil 15kg, conjugated linoleic acid glycerides 5kg, linseed oil 8kg, olive oil 8kg, fish oil 5kg, high oleic sunflower oil 5kg, soybean oil 5kg, whey protein concentrate 15kg, soybean protein isolate 8kg, Hydrolyzed fish collagen 2kg, casein 5kg, rice protein 5kg, quinoa flour 2kg, chia seeds 1kg, konjac powder 3kg, inulin 1kg, fructooligosaccharide 1kg, L-carnitine 0.5kg, glutamine 1.5kg, enzyme 1.5kg, multivitamin 0.3kg, and multivitamin 2kg According to the above formula, all ingredients are weighed and passed through an 80-mesh sieve, and the unsifted parts are crushed and re-sieved until all the ingredients are sieved. 20g per pack of finished product.

Embodiment 2

[0104] Embodiment 2 clinical trials

[0105] According to the two national standards of "General Rules for Formulas for Special Medical Purposes" (GB29922-2013) and "Good Manufacturing Practices for Formulas for Special Medical Purposes" (GB29923-2013) published by the National Health and Family Planning Commission in 2013, the prepared product in Example 1 Meal replacement powder is undergoing clinical trials for effect evaluation.

[0106] Preliminary experimental results and effect evaluation:

[0107] The tested PCOS patients underwent 8-week ketogenic meal replacement powder dietary intervention and found that the changes in related indicators before and after the intervention:

[0108] Body weight (-8.61±2.34) kg, P<0.001;

[0109] Body mass index (BMI) (-3.25±0.88) kg / m 2 , P<0.001;

[0110] Waist circumference (-8.4±3.1) cm, P<0.001;

[0111] Fasting insulin (-17.0±13.6) μg / mL, P<0.001;

[0112] 2h insulin (-82.8±177.7) μg / mL, P<0.05;

[0113] Total testosterone...

Embodiment 3

[0117] Embodiment 3 animal experiments

[0118] 1 Materials and methods

[0119] 1.1 Animal model construction and administration

[0120] The 70-day-old healthy and clean female SpraguDawley (SD) rats were selected to establish the polycystic ovary syndrome (PCOS) rat model according to the Poretsky method, and 3.0 U / d of human chorionic gonadotropin (HCG) was injected subcutaneously twice a day. From day 1 to day 10, the injection of intermediate-acting insulin started from 0.5U / d and gradually increased to 6.0U / d, and then injected at this dose every day. After 22 days, the levels of testosterone and insulin in the blood of the rats increased and the vaginal smears continued to appear angular. Cellular cells are in line with the PCOS model.

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PUM

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Abstract

The invention relates to low-GI total-nutrient meal replacement powder for intervening polycystic ovarian syndrome based on a ketogenesis principle and application of the low-GI total-nutrient meal replacement powder. The meal replacement powder is prepared from the following raw materials: freshly squeezed coconut oil, conjugated linoleic acid glyceride, linseed oil, olive oil, fish oil, high oleic acid sunflower seed oil, soybean oil, whey protein concentrate, soy isolate protein, hydrolyzed fish collagen, casein, rice protein, quinoa flour, chia seeds, konjac powder, inulin, fructo-oligosaccharide, L-carnitine, glutamine, enzymes, vitamin complex and mineral complex. The formula has the advantages that the energy supply ratio of the three nutrients is as follows: 70%-75% of fat, 3%-5% of carbohydrate and 20%-27% of protein. By utilizing the characteristics that MCT (medium-chain fatty acid) does not store fat and can quickly supply energy to a human body, insulin resistance is reduced, glycolipid metabolism disorder is improved, and the purpose of reducing weight is achieved. A scientific and convenient ketogenic diet replacement scheme is provided, and the ketogenic diet replacement scheme is convenient to implement and popularize in crowds.

Description

technical field [0001] The invention relates to the technical field of formula food for special medical purposes (FSMP), in particular to a low-GI full-nutrition meal replacement powder for intervening polycystic ovary syndrome based on the principle of ketogenicity and its application. Background technique [0002] Polycystic ovary syndrome (PCOS) is an endocrine disorder syndrome characterized by persistent anovulation, hyperandrogenism, and polycystic changes in the ovary, which not only affects the reproductive function of patients , will also increase the risk of endometrial cancer, type 2 diabetes, and cardiovascular disease. Affecting 5% to 20% of women of childbearing age, it is one of the most common causes of infertility and metabolic disorders. Its etiology and mechanism are still unclear, and there is no effective cure. [0003] Research significance of the present invention: [0004] The incidence of PCOS is increasing year by year. With the opening of the "tw...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L33/115A23L33/19A23L33/185A23L33/17A23L33/10A23L33/125A23L33/175A23L33/00A23L33/15A23L33/16A23L33/12A23L33/155A23L7/10A23L19/10A61K36/889A61K38/01A61K38/17A61P3/06A61P3/10A61P5/00A61P5/50A61P15/08A61K31/07A61K31/19A61K31/197A61K31/198A61K31/205A61K31/355A61K31/375A61K31/4415A61K31/455A61K31/51A61K31/525A61K31/593A61K31/702A61K31/733A61K33/06A61K33/30A61K33/42A61K35/60
CPCA23L33/115A23L33/19A23L33/185A23L33/17A23L33/10A23L33/125A23L33/175A23L33/00A23L33/15A23L33/16A23L33/155A23L33/12A23L7/10A23L19/115A23L33/40A61K36/889A61K36/55A61K36/32A61K35/60A61K36/28A61K36/48A61K38/1709A61K36/185A61K36/53A61K36/888A61K31/733A61K31/702A61K31/205A61K31/198A61K31/07A61K31/51A61K31/525A61K31/4415A61K31/375A61K31/593A61K31/355A61K31/455A61K31/197A61K33/30A61K31/19A61K33/42A61K33/06A61K36/064A61K38/011A61K38/014A61P15/08A61P3/10A61P3/06A61P5/00A61P5/50A23V2002/00A23V2200/326A23V2200/30A23V2250/18A23V2250/5488A23V2250/54246A23V2250/54252A23V2250/5482A23V2250/5062A23V2250/28A23V2250/70A23V2250/0612A23V2250/702A23V2250/7042A23V2250/7044A23V2250/7052A23V2250/708A23V2250/7106A23V2250/712A23V2250/7046A23V2250/705A23V2250/1592A23V2250/1614A23V2250/1642A23V2250/1578A23V2250/161A23V2250/1586A61K2300/00
Inventor 张洁张浩
Owner JINSHAN HOSPITAL FUDAN UNIV
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