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Low-GI total-nutrient meal replacement powder for intervening polycystic ovarian syndrome based on ketogenesis principle and application of low-GI total-nutrient meal replacement powder
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A technology of polycystic ovary and meal replacement powder is applied in the directions of application, active ingredients of hydroxyl compounds, medical raw materials derived from fish feed, etc.
Pending Publication Date: 2021-02-12
JINSHAN HOSPITAL FUDAN UNIV
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Problems solved by technology
There is no report about a low-GI full-nutritionmeal replacement powder and its application based on the principle of ketogenic intervention in polycystic ovary syndrome of the present invention
Method used
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[0105] According to the two national standards of "General Rules for Formulas for Special Medical Purposes" (GB29922-2013) and "Good Manufacturing Practices for Formulas for Special Medical Purposes" (GB29923-2013) published by the National Health and Family Planning Commission in 2013, the prepared product in Example 1 Meal replacement powder is undergoing clinical trials for effect evaluation.
[0106] Preliminary experimental results and effect evaluation:
[0107] The tested PCOS patients underwent 8-week ketogenic meal replacement powder dietary intervention and found that the changes in related indicators before and after the intervention:
[0119] 1.1 Animal model construction and administration
[0120] The 70-day-old healthy and clean female SpraguDawley (SD) rats were selected to establish the polycystic ovary syndrome (PCOS) rat model according to the Poretsky method, and 3.0 U / d of human chorionic gonadotropin (HCG) was injected subcutaneously twice a day. From day 1 to day 10, the injection of intermediate-acting insulin started from 0.5U / d and gradually increased to 6.0U / d, and then injected at this dose every day. After 22 days, the levels of testosterone and insulin in the blood of the rats increased and the vaginal smears continued to appear angular. Cellular cells are in line with the PCOS model.
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technical field [0001] The invention relates to the technical field of formula food for special medical purposes (FSMP), in particular to a low-GI full-nutritionmeal replacement powder for intervening polycystic ovary syndrome based on the principle of ketogenicity and its application. Background technique [0002] Polycystic ovary syndrome (PCOS) is an endocrine disorder syndrome characterized by persistent anovulation, hyperandrogenism, and polycystic changes in the ovary, which not only affects the reproductive function of patients , will also increase the risk of endometrial cancer, type 2 diabetes, and cardiovascular disease. Affecting 5% to 20% of women of childbearing age, it is one of the most common causes of infertility and metabolic disorders. Its etiology and mechanism are still unclear, and there is no effective cure. [0003] Research significance of the present invention: [0004] The incidence of PCOS is increasing year by year. With the opening of the "tw...
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