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Coenzyme Q10 drug delivery system and preparation method thereof

A drug delivery system and coenzyme technology, which can be used in drug combinations, pharmaceutical formulations, cardiovascular system diseases, etc., can solve problems such as instability, low drug loading, and emulsifier toxicity, reduce loss rate, improve solubility, The effect of improving solubility

Active Publication Date: 2021-02-19
ZHEJIANG UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For example, Huibin LiSaudi prepared CoQ10 long-circulation liposomes by film dispersion method, which improved the stability of the drug, but the drug loading was relatively small; FiammettaNigroa used Cuban oil of 2% w / w coenzyme Q10 as the oil phase, and prepared by ultrasonic method Q10 nanoemulsion has improved solubility, but the emulsifier has a certain degree of slight toxicity; Jin-SeokChoi et al. use poloxamer 407 (Kolliphor P407) as the main solubilizer and polyvinylpyrrolidone (Kollidon 17) as the co-solubilizer by hot melt method. Solubilizer, Aerosil 200 is used as the carrier to prepare coenzyme Q10 solid dispersion, which improves the solubility, but it is unstable when stored for a long time

Method used

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  • Coenzyme Q10 drug delivery system and preparation method thereof
  • Coenzyme Q10 drug delivery system and preparation method thereof
  • Coenzyme Q10 drug delivery system and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Add 2g of coenzyme Q10, 32g of protamine, 0.055g of micropowdered silica gel, 0.35g of 2,6-di-tert-butyl-4-methylphenol (BHT), 4.45g of poloxamer into a 500 mL stainless steel ball mill jar, 64 stainless steel ball milling beads with a diameter of 15 mm were ground for reaction at 200 rpm for 4 hours. After the reaction, the drug was separated from the stainless steel ball milling beads to obtain a coenzyme Q10 drug delivery system.

Embodiment 2

[0030] Add 1g of coenzyme Q10, 30g of soybean protein, 0.05g of talcum powder, 0.35g of DL tocopherol, 4.55g of monoglyceride and diglyceride stearate, and 64 stainless steel ball milling beads with a diameter of 15mm into a 500 mL stainless steel ball mill jar, at 200rpm The reaction was ground for 4 hours, and the drug was separated from the stainless steel ball milling beads after the reaction to obtain a coenzyme Q10 drug delivery system.

Embodiment 3

[0032] Add 6g of coenzyme Q10, 25g of casein and hemoglobin, 0.05g of tricalcium phosphate, 0.45g of vitamin palmitate, 4.45g of disodium glycyrrhizinate and sodium caseinate into a 500 mL stainless steel ball mill jar, and stainless steel ball milling beads with a diameter of 25mm 64 were ground for 4 hours at 100rpm. After the reaction, the drug was separated from the stainless steel ball milling beads to obtain a coenzyme Q10 drug delivery system.

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Abstract

The invention discloses a coenzyme Q10 drug delivery system and a preparation method thereof. The coenzyme Q10 drug delivery system is composed of coenzyme Q10, a protein carrier, a surfactant, a stabilizer and a lubricant, stainless steel balls serve as a grinding medium, raw materials and the stainless steel balls are added into a ball milling tank for a co-grinding reaction, the stainless steelballs are separated out after the reaction is finished, and the coenzyme Q10 drug delivery system is obtained. By adopting the above technology, the in-vivo circulation time of the coenzyme Q10 can be prolonged, the oral absorption of medicines can be improved, the transmembrane transport capacity of the medicines can be improved, and the effect of the coenzyme Q10 in heart health care can be further exerted. The drug delivery system for preparing the coenzyme Q10 by adopting a mechanochemical ball milling method is simple to operate and short in process route, a solvent and heating are not needed in the preparation process, and the loss rate of the coenzyme Q10 in the process is reduced. According to the prepared coenzyme Q10 drug delivery system, the stability of the coenzyme Q10 is obviously improved.

Description

technical field [0001] The invention belongs to the technical field of development of pharmaceutical preparations and health care products, and specifically relates to a coenzyme Q10 drug delivery system and a preparation method thereof. The method is to prepare the coenzyme Q10 drug delivery system with protein as a carrier by mechanochemical ball milling. Background technique [0002] Coenzyme Q10 is a fat-soluble quinone compound that exists widely in organisms. The number of isoprene units in the side chain of coenzyme Q from different sources is different. Humans and mammals have 10 isoprene units, so it is called coenzyme Q10 (Redox Biology, 2015, 4: 289-295). Coenzyme Q10 mainly exists in the inner membrane of mitochondria and participates in the electron transport chain in the process of oxidative phosphorylation (a major cellular energy production mechanism). It is an activator of cellular respiration and cellular metabolism. It has antioxidant effects and can elimi...

Claims

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Application Information

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IPC IPC(8): A61K31/122A61K47/42A61P9/04A61P9/12A61P9/00B02C17/10
CPCA61K31/122A61K47/42A61P9/04A61P9/12A61P9/00B02C17/10
Inventor 许文灏李达梅苏为科
Owner ZHEJIANG UNIV OF TECH
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