Medical nerve grafting repair film and preparation method thereof

Abstract

The invention discloses a medical nerve grafting repair film and a preparation method thereof. The preparation method comprises the steps of material selection, impure protein removal, virus inactivation, collagen degreasing, casing extension, chitosan atomization, dressing shaping, dressing solidification, cutting and inspection, packaging, sterilization and the like. Chitosan has antibacterial activity, can resist microbial infection, induce tissue regeneration and accelerate growth and healing of nerve fibers, and does not cause any inflammatory reaction in tissue; collagen has hemostatic and repairing functions, has bioabsorbability and cell adhesion, and can promote the formation of new cells and nerve cells; the product is low in antigenicity, good in human tissue compatibility, stable in absorption period through automatic coordination and absorption of enzymes and body fluid, and finally completely absorbed by a human body; the burn and scald repair film prepared by the methodhas the characteristics of uniform texture, good elasticity, high transparency, good air permeability, good biocompatibility, small toxic and side effects and the like, and the dressing can be absorbed by organisms.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to a medical nerve graft repair membrane and a preparation method thereof. Background technique [0002] The nervous system is the most important organ in the human body. It is composed of two major parts, the central nervous system and the peripheral nerve. The central nervous system refers to the brain and spinal cord, and the peripheral nerve refers to the nerve fibers that leave the brain and spinal cord. An aggregate of nerve bundles (visible to the naked eye) that are further wrapped by connective tissue on the basis of the same nerve bundles. Peripheral nerve damage manifests as sensory disturbance, motor disturbance and nutritional disturbance in the area innervated by the nerve due to various reasons. Only when the damaged nerve is repaired, the normal function of the organ can be fully restored. [0003] After the peripheral nerve is disconnected and injured, it can g...

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Problems solved by technology

[0003] After the peripheral nerve is disconnected and injured, it can grow from the proximal end to the distal end at a speed of about 1 mm / day. Clinically, it is often repaired by anastomosis of the severed nerve. However, the following problems still exist after the nerve anastomosis: local lack of A good microenvironment that promotes the growth of nerve fibers makes it difficult to form a "regeneration chamber" effect that is conducive to nerve fiber regeneration; the exposure of the anastomosis and the outflow of nerve growth factors will also reduce the repair effect of the nerve; fibrous tissue invades the anastomosis to form scars, hindering Regenerated fibers grow into the distal end of the nerve through the anastomosis; growth-arrested regenerated fibers are prone to local neurofibroma formation