Medical nerve grafting repair film and preparation method thereof

A nerve and casing technology, applied in the field of biomedicine, can solve problems such as hindering the growth of regenerative fibers into the distal end of the nerve, the formation of neurofibromas, and the lack of a microenvironment for the growth of nerve fibers, etc., so as to achieve less adverse tissue reactions and less contamination. Bacteria, accelerated growth and healing effect

Inactive Publication Date: 2021-03-12
山东康利达医用制品有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] After the peripheral nerve is disconnected and injured, it can grow from the proximal end to the distal end at a speed of about 1 mm/day. Clinically, it is often repaired by anastomosis of the severed nerve. However, the following problems still exist after the nerve anastomosis: local lack of A good microenvironment that promotes the growth of nerve fibers makes it difficult to form a "regenera...

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] The preparation method of a kind of medical nerve graft repair membrane of this embodiment, this preparation method is carried out according to the following steps:

[0027] (1) Select the casings that have passed the quarantine and cut off the small intestine;

[0028] (2) Remove impurities: clean the inner wall of the casing of the small intestine, and separate and shed the intestinal chorion, mucous membrane, and serosa in the casing with special equipment;

[0029] (3) Virus inactivation: Soak the casings from which impurities have been removed in an edible hydrogen peroxide solution with a water temperature of 35°C and a concentration of 6% for 10 hours, and then wash them 4 times with purified water.

[0030] (4) Collagen degreasing: clean the above-mentioned sausage casing with clean water, put it into a 13% sodium chloride solution and soak for 70 minutes, then separate and remove the fat in the collagen of the casing to obtain relatively pure collagen tissue; ...

Embodiment 2

[0038] The preparation method of a kind of medical nerve graft repair membrane of this embodiment, this preparation method is carried out according to the following steps:

[0039] (1) Select the casings that have passed the quarantine and cut off the small intestine;

[0040] (2) Remove impurities: clean the inner wall of the casing of the small intestine, and separate and shed the intestinal chorion, mucous membrane, and serosa in the casing with special equipment;

[0041] (3) Virus inactivation: Soak the casing from which impurities have been removed in a 7% edible hydrogen peroxide solution at a water temperature of 36°C for 11 hours, then wash it 5 times with purified water.

[0042] (4) Collagen degreasing: clean the above casing with water, put it into 14% sodium chloride solution and soak for 73 minutes, then separate and remove the fat in the collagen of the casing to obtain relatively pure collagen tissue;

[0043] (5) Casing extension: After cutting the casing int...

Embodiment 3

[0050] The preparation method of a kind of medical nerve graft repair membrane of this embodiment, this preparation method is carried out according to the following steps:

[0051] (1) Select the casings that have passed the quarantine and cut off the small intestine;

[0052] (2) Remove impurities: clean the inner wall of the casing of the small intestine, and separate and shed the intestinal chorion, mucous membrane, and serosa in the casing with special equipment;

[0053] (3) Virus inactivation: Soak the casing from which impurities have been removed in an edible hydrogen peroxide solution with a water temperature of 37°C and a concentration of 8% for 12 hours, then wash it 6 times with purified water.

[0054] (4) Collagen degreasing: clean the above casing with water, put it into 15% sodium chloride solution and soak for 76 minutes, then separate and remove the fat in the collagen of the casing to obtain a relatively pure collagen tissue;

[0055] (5) Casing extension: Af...

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Abstract

The invention discloses a medical nerve grafting repair film and a preparation method thereof. The preparation method comprises the steps of material selection, impure protein removal, virus inactivation, collagen degreasing, casing extension, chitosan atomization, dressing shaping, dressing solidification, cutting and inspection, packaging, sterilization and the like. Chitosan has antibacterial activity, can resist microbial infection, induce tissue regeneration and accelerate growth and healing of nerve fibers, and does not cause any inflammatory reaction in tissue; collagen has hemostatic and repairing functions, has bioabsorbability and cell adhesion, and can promote the formation of new cells and nerve cells; the product is low in antigenicity, good in human tissue compatibility, stable in absorption period through automatic coordination and absorption of enzymes and body fluid, and finally completely absorbed by a human body; the burn and scald repair film prepared by the methodhas the characteristics of uniform texture, good elasticity, high transparency, good air permeability, good biocompatibility, small toxic and side effects and the like, and the dressing can be absorbed by organisms.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to a medical nerve graft repair membrane and a preparation method thereof. Background technique [0002] The nervous system is the most important organ in the human body. It is composed of two major parts, the central nervous system and the peripheral nerve. The central nervous system refers to the brain and spinal cord, and the peripheral nerve refers to the nerve fibers that leave the brain and spinal cord. An aggregate of nerve bundles (visible to the naked eye) that are further wrapped by connective tissue on the basis of the same nerve bundles. Peripheral nerve damage manifests as sensory disturbance, motor disturbance and nutritional disturbance in the area innervated by the nerve due to various reasons. Only when the damaged nerve is repaired, the normal function of the organ can be fully restored. [0003] After the peripheral nerve is disconnected and injured, it can g...

Claims

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Application Information

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IPC IPC(8): A61L27/36A61L27/24A61L27/34A61L27/54A61L27/50A61L27/58
CPCA61L27/24A61L27/34A61L27/3629A61L27/3675A61L27/3687A61L27/3691A61L27/50A61L27/54A61L27/58A61L2300/232A61L2300/252A61L2300/404A61L2300/412A61L2300/418A61L2300/606A61L2430/32A61L2430/40C08L5/08
Inventor 王桂发王亚群
Owner 山东康利达医用制品有限公司
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