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Berberine/mineralized collagen composite membrane as well as preparation method and application thereof

A technology for mineralizing collagen and berberine, which can be applied to inactive components of polymer compounds, drug combinations, and pharmaceutical formulations, etc., can solve problems such as low bioavailability, anaphylactic shock, and adverse reactions, and achieve good and good results. Osteogenic activity and less side effects

Active Publication Date: 2021-03-16
WEIFANG MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Two dosage forms of berberine commonly used clinically are tablets and injections. Oral tablets have disadvantages such as poor absorption and low bioavailability; injections have rapid drug metabolism after injection, require frequent injections, and are too large The dosage is likely to cause anaphylactic shock, drug eruption and other adverse reactions, and there are certain problems in clinical application

Method used

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  • Berberine/mineralized collagen composite membrane as well as preparation method and application thereof
  • Berberine/mineralized collagen composite membrane as well as preparation method and application thereof
  • Berberine/mineralized collagen composite membrane as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0057] (1) Dissolve chitosan (molecular weight: 12-16kDa) in 1wt% glacial acetic acid solution under magnetic stirring conditions, then add mineralized collagen and perform ultrasonication and stirring in turn to obtain mineralized collagen suspension, in which the shell The mass fraction of glycans is 2%, and the mass fraction of mineralized collagen is 0.8%;

[0058] Pour 5 mL of the obtained mineralized collagen suspension into a plastic watch glass with a diameter of 10 cm, spread it flat, and dry it in an oven at 37 ° C for 2 hours to obtain a mineralized collagen film. The mass fraction of chitosan in the obtained mineralized collagen film is 71.43%, and the mass fraction of mineralized collagen is 28.57%;

[0059] (2) Berberine is dissolved in a mixed solvent of chloroform and methanol (the volume ratio of chloroform and methanol is 3:1) to obtain a berberine solution, and then polycaprolactone is dissolved in berberine In solution, obtain the polycaprolactone-berberin...

Embodiment 2

[0063] Other conditions were the same as in Example 1, except that the concentration of berberine in the electrospinning solution was changed to 5 μmol / L.

Embodiment 3

[0065] Other conditions were the same as in Example 1, except that the concentration of berberine in the electrospinning solution was changed to 30 μmol / L.

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Abstract

The invention relates to the technical field of bone repair, and provides a berberine / mineralized collagen composite membrane as well as a preparation method and application thereof. The composite membrane provided by the invention comprises a berberine nanofiber membrane and a mineralized collagen membrane arranged on the surface of one side of the berberine nanofiber membrane. According to the invention, mineralized collagen with the capacity of biomimetic mineralization is combined with traditional Chinese medicine monomer berberine, the obtained composite membrane has a better osteogenesispromoting effect, a new administration dosage form of berberine is constructed, and the defects of low bioavailability, frequent administration, large adverse reaction and the like of the traditionalberberine dosage form are overcome. The berberine nanofiber membrane is prepared by adopting an electrostatic spinning method, the mineralized collagen membrane is used for receiving berberine nanofibers, or the mineralized collagen membrane is prepared on the surface of the berberine nanofiber membrane by adopting a coating mode after the berberine nanofiber membrane is prepared. The preparationmethod is simple, the cost is low, and industrial production is easy to carry out.

Description

technical field [0001] The invention relates to the technical field of bone repair, in particular to a berberine / mineralized collagen composite film and its preparation method and application. Background technique [0002] Bone defect is a common clinical disease, usually caused by injury, tumor, infection and other reasons. The incidence of bone defect is very high, and it is difficult to heal itself when the defect exceeds a certain range, and bone tissue needs to be repaired by external force. At present, there are three common clinical methods, including autologous bone transplantation, allogeneic bone transplantation and artificial bone material implantation. After bone tissue repair, it is usually necessary to use drugs to promote the growth of bone tissue and guide the regeneration of bone defects. [0003] Berberine is a common natural alkaloid in clinical practice. It is widely found in the rhizomes of Coptis chinensis, Ranunculus radix, barberry, three needles an...

Claims

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Application Information

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IPC IPC(8): A61K9/70A61K31/4375A61K47/34A61K47/42A61K47/32A61K47/36A61K47/02A61P19/08D04H1/728D04H3/02D04H13/00D01D5/00
CPCA61K9/7007A61K31/4375A61K47/34A61K47/42A61K47/32A61K47/36A61K47/02A61P19/08D04H1/728D04H3/02D04H13/00D01D5/0084D01D5/003D10B2509/00A61L27/46D01F6/625D01D5/0038D01F1/10D06M23/10D06M15/03A61L2430/02A61L2400/12A61L27/26A61L27/54A61L2300/208D06M15/15C08L89/06C08L5/08C08L67/04C08L39/06A61F2/30965A61L27/20A61L27/24A61L27/48A61L27/58D04H1/4282D04H1/435D04H3/007D04H3/011D04H3/16D06M2101/18D06M2101/32D10B2321/12D10B2331/041
Inventor 张维芬张玉晗丁德军关秀文马金龙张竞竞
Owner WEIFANG MEDICAL UNIV
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