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A supported composite metal catalyst suitable for acetonitrile hydration reaction to prepare acetamide and its preparation method and application

A composite metal and nitrile hydration technology, applied in catalyst activation/preparation, metal/metal oxide/metal hydroxide catalysts, chemical instruments and methods, etc., can solve problems such as no relevant research reports on acetamide

Active Publication Date: 2021-09-14
SHANXI INST OF COAL CHEM CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

After searching, there is no relevant research report on the application of this type of metal catalyst to the hydration reaction of acetonitrile to prepare acetamide

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Take the Ni ion concentration as 0.032 g·mL -1 10 mL of nickel nitrate solution, the Mn ion concentration is 0.038 g·mL -1 10 mL of manganese nitrate solution, Mg ion concentration is 0.06 g·mL -1 1 mL of magnesium nitrate solution was prepared as a mixed metal nitrate solution, and SiO with a particle size of 90 nm was added to the mixed solution 2 Solid 8.9 g, and stir evenly, then add the H that concentration is 0.3 mol / L 3 PO 4 10 mL of the solution, stirred again to mix evenly, soaked for 6 h, then at 120 o Dry under the condition of C for 16 h, grind the obtained solid, 400 o C under calcination for 5 h to obtain the catalyst. Take 10 g of catalyst raw powder to shape, and then crush it to 80 mesh, and fill 5 g of 80 mesh catalyst in the fixed bed reactor. The reaction conditions for preparing acetamide by catalyzing the hydration reaction of acetonitrile are: acetonitrile and water are fed in liquid form, the molar ratio of acetonitrile and water is 1:6, an...

Embodiment 2

[0026] Take Ni ion concentration as 0.24 g·mL -1 1 mL of nickel nitrate solution, the concentration of Mn ions is 0.015 g·mL -1 Manganese nitrate solution 10 mL, In ion concentration 0.08 g·mL -1 1 mL of indium nitrate solution was prepared as a mixed metal nitrate solution, and SiO with a particle size of 90 nm was added to the mixed solution 2 Solid 9.4 g, and stir evenly, then add the H that concentration is 0.25mol / L 3 PO 4 Solution 10 mL, stir again to mix evenly, soak for 8 h, then at 140 o Under the condition of C, dry for 20 h, grind the obtained solid, 550 o The catalyst was obtained by calcining for 8 h under the condition of C. Take 10 g of catalyst raw powder to shape, and then crush it to 80 mesh, and fill 5 g of 80 mesh catalyst in the fixed bed reactor. The reaction conditions for preparing acetamide by catalyzing the hydration reaction of acetonitrile are: acetonitrile and water are fed in liquid form, the mole fraction ratio of acetonitrile and water is ...

Embodiment 3

[0028] Take the Ni ion concentration as 0.13 g·mL -1 10 mL of nickel nitrate solution, the concentration of Mn ions is 0.023 g·mL -1 Manganese nitrate solution 10 mL, Ca ion concentration 0.07 g·mL -1 1 mL of zinc nitrate solution was prepared as a mixed metal nitrate solution, and SiO with a particle size of 70 nm was added to the mixed solution 2 Solid 17.9 g, and stir evenly, then add the H that concentration is 0.45 mol / L 3 BO 3 solution 10 mL, stirred again to mix evenly, soaked for 7 h, then at 100 o Dry under the condition of C for 24h, the obtained solid is ground, 500 o C under the condition of calcination for 6 h to obtain the catalyst. Take 10 g of catalyst raw powder for molding, and then crush it to 60 mesh, and fill 5 g of 60 mesh catalyst in the fixed bed reactor. The reaction conditions for preparing acetamide by catalyzing the hydration reaction of acetonitrile are: acetonitrile and water are fed in liquid form, the molar ratio of acetonitrile and water ...

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Abstract

The invention relates to the field of acetonitrile hydration reaction catalyst. A supported composite metal catalyst suitable for the preparation of acetamide by the hydration reaction of acetonitrile, comprising a metal oxide, an additive and a SiO2 carrier, wherein the metal oxide is 0.5-20 wt%, the additive is 0.1-1 wt%, and the rest is SiO2 , the metal oxide is one or more of Ni and Mn metal oxides and Mg, Ca, In, Ga, Bi, Zr oxides, and the additive is phosphorus or boron. The invention also relates to the preparation method and application of the catalyst. The present invention develops a high-efficiency and low-cost catalytic method for the preparation of acetamide by acetonitrile hydration. The process is simple, there is no "three wastes", the selectivity of the target product is >99%, the purity of the product acetamide is >99.7%, and the water content is <0.5%, which can completely reach the pharmaceutical industry. the standard used.

Description

technical field [0001] The invention relates to the field of acetonitrile hydration reaction catalyst. Background technique [0002] Acetamide has many uses and is widely used in chemical industry, plastics, dyestuff, medicine, pesticide and other industries. It can be used as a solubilizer when some substances with low solubility in water are dissolved in water, such as a solvent and solubilizer for dyes in the fiber industry, and a solvent in the synthesis of antibiotics such as chloramphenicol. Acetamide is slightly alkaline and can be used as an antacid for varnishes, explosives and cosmetics. Acetamide is hygroscopic and can be used as a wetting agent for dyeing; it can also be used as a plasticizer for plastics. N-halogenated acetamide produced by chlorination or bromination of acetamide is a halogenation reagent in organic synthesis. Acetamide is also a raw material for the manufacture of drugs and fungicides. For example, it is a raw material for the drug intermed...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01J23/889B01J27/187B01J37/02C07C231/06C07C233/05
CPCB01J23/8892B01J27/187B01J37/0201C07C231/06C07C233/05
Inventor 宋清文韩丽华刘平张侃荀家瑶张乾霞范伟强
Owner SHANXI INST OF COAL CHEM CHINESE ACAD OF SCI
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