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Zwitterionic polymers for biomedical applications

A zwitterionic, polymer technology, used in medical science, prostheses, catheters, etc., can solve problems such as unsolved PEG

Pending Publication Date: 2021-04-16
THE BOARD OF TRUSTEES OF THE UNIV OF ILLINOIS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although PEG has been widely used alone or in combination with other components for antifouling purposes for nearly 30 years, key challenges in in vivo applications of PEG, such as foreign body reactions, infection, and thrombosis, remain unsolved

Method used

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  • Zwitterionic polymers for biomedical applications
  • Zwitterionic polymers for biomedical applications
  • Zwitterionic polymers for biomedical applications

Examples

Experimental program
Comparison scheme
Effect test

example

[0169]material

[0170]Diethanolamine, 2-hydroxyethyl acrylate, ethyl acrylate and isocyanate fluorescein isomer 1 is purchased from Alfa Aser (HAVERHILL, MA)) in Massachusetts Black Filier. Polyethylene glycol (PEG) 2000, glycerol, bovine serum albumin (BSA) purchased Sigma Aldrich (Sigma Aldrich (St.Louis, Mo, USA) from Missouri, USA. 1,6-diisocyanate-hexane (HDI) is purchased from Acros Organics (Pittsburg, PA, USA) from Pittsburgh, Pennsylvania, USA. Dimethylformamide (DMF) was purchased from the EMD Millipore (Burlington, MA, USA), Burlington, Massachusetts, USA. The survival / cytotoxic assay kit for bacterial live cells and dead cells was purchased from Biotium (Biotium (Fremont, CA, USA), Fremont, California, USA. Commercial creature polyurethane materials were purchased from the API of Italian Vichen Province, Musologue (Mussolente, Vi, Italy).

[0171]Instrument and method

[0172]Fourier transform infrared spectroscopy (FTIR)

[0173]Fourier transform infrared spectroscopy (FTIR) ...

example 1

[0194]Synthesis and assessment of 1-zwitterionic polymer

[0195]Overview

[0196]A series of zymnial ion poly (carboxykyl alkali-urethane) (PCBHU), which can be easily adjusted by chamber by chamber by chamber and hard segments employed in the synthesis. Double function of surface anti-fouling characteristics and spontaneous properties in a polymerized biological material. Characterization of the chemical structure, thermal stability, thermal transformation, and mechanical properties of the resulting polymer having different components ratios. Hydrolysis kinetics of polyaminometate in different pH solutions. The protein adsorption on PCBHU was evaluated as a model protein using bovine serum albumin (BSA). Cells were performed on the surface of the hydrogel, and the bacteria adhesion and biofilm were formed to additionally show the antifouling properties of the amphoteric ion PCBHU.

[0197]Synthesis and Characterization of a range of new type ionic polycarboxyklarine urethane (PCBU) with a...

example 2

[0232]Synthesis and assessment of 2-amphoteric ion polymers

[0233]Synthesis of diethanol uthyl acrylate (DEAEA)

[0234]Synthesis DEAEA (the structure provided below) was synthesized using Michael.

[0235]

[0236]Dielethanolamine (50 g, 0.476 mol) was added dropwise to ethyl acrylate (48 g, 0.48 mol) under purge nitrogen. The resulting solution was stirred at 35 ° C overnight. The reaction mixture was concentrated in a rotary evaporator and then purified by flash chromatography using dichloromethane and methanol mixture (9: 1) as a flow phase to produce DEAEA. 1H NMR (400 MHz, CDCl3, PPM): 3.46 (t, 4h), 2.74 (t, 2h), 2.36 (T, 2H), 1.14 (T, 3H), 4.01 (M, 2H) ).

[0237]Synthesis of polymers

[0238]The chemical metric ratio of the isocyanate group in the hydroxy / glycerol / HDI in five DEAEA is prepared (100: 0: 100, 75: 25: 100, 50: 50: 100, 25: 75: 100 and 0: 100: 100) and named DHG-0, DHG-25, DHG-50, DHG-75, and DHG-100, respectively. The ratio of the isocyanate group in the hydroxyl / PEG in...

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Abstract

Provided herein are polymers having a polymer backbone including a zwitterionic precursor monomeric unit having a secondary or tertiary amine in the polymer backbone, as well as methods of making and using the same.

Description

[0001]Cross-reference [0002]The present application claims priority to the US Provisional Patent Application No. 62 / 659,939, filed on April 19, 2018, which is incorporated herein by reference.Technical field[0003]The present disclosure relates to polymers having an adjustable mechanical swelling characteristic having an amphoteric ion precursor unit, which are used, and the preparation thereof.Background technique[0004]Polyurethane (PU) comprises a common material having a commonly characterized material having a urethane bond along the polymer backbone. In recent years, various PUs have been developed to provide good biocompatibility, high strength, high elasticity and processing versatility in a wide range of biomedical applications. These properties are important for the application of the catheter, drug delivery, tissue engineering, and various injection molding devices. Since the hydrogen bond formation group, it is found that the protein absorption on the PU as the initial s...

Claims

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Application Information

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IPC IPC(8): A61L31/06C08G61/12
CPCA61L31/06A61L27/18A61L27/54A61L29/06A61L31/16A61L29/16C08G18/0833C08G18/10C08G18/4833C08G18/3275C08G18/3821C08G18/8041C08G18/8054C08G18/3206C08G18/73C08G2210/00C08L75/04
Inventor 程钢H·王
Owner THE BOARD OF TRUSTEES OF THE UNIV OF ILLINOIS
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