Antibacterial elastic composite medical dressing and preparation method thereof

A medical and elastic technology, which is applied in the fields of medical formula, medical science, non-woven fabrics, etc., can solve the problems of unfavorable wound adhesion, low elongation at break, uneven thickness, etc., and achieve isolation of bacterial infection, high strength, and preparation The effect of simple process

Pending Publication Date: 2021-05-07
ANHUI UNIVERSITY OF TECHNOLOGY AND SCIENCE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the naturally grown bacterial cellulose has an uneven surface and uneven thickness in a dry state, which is not conducive to bonding with the wound surface.
In addition, although bacterial cellulose nano has high modulus and high strength, its elongation at break is low, which indicates that its ductility is poor and it is easy to be brittle during use.

Method used

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  • Antibacterial elastic composite medical dressing and preparation method thereof
  • Antibacterial elastic composite medical dressing and preparation method thereof
  • Antibacterial elastic composite medical dressing and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] 1. Accurately weigh 2.88g of polyurethane (PU) masterbatch, 0.72g of polycaprolactone (PCL) and 0.036g of TiO 2Nanoparticles, be dissolved in 16.4g N, in the N-dimethylformamide (DMF), stir with magnetic stirrer at room temperature until polyurethane and polycaprolactone dissolve completely, obtain the uniform and stable solute mass fraction of 18%. spinning solution. The above spinning solution was used for electrospinning. Set the electrospinning process parameters as follows: the distance between the spinneret and the receiving plate is 15cm, the flow rate of the spinning solution is 1.2ml / h, the applied voltage is 18kV, and the aluminum foil is received for 20h to obtain PU / PCL / TiO 2 Composite nanofiber membrane.

[0040] 2. Use Acetobacter xylinum as the strain for cultivating bacterial cellulose membranes, accurately weigh 3g of tryptone, 5g of yeast powder and 25g of mannitol, distill the volume to 1L with distilled water and pack them in each Erlenmeyer flask,...

Embodiment 2

[0045] 1. Accurately weigh 2.8g of polyurethane (PU) masterbatch, 1.2g of polycaprolactone (PCL) and 0.2g of TiO 2 Nanoparticles, dissolved in 16g of N, N-dimethylformamide (DMF), stirred with a magnetic stirrer at room temperature until the polyurethane and polycaprolactone were completely dissolved to obtain a uniform and stable spinning with a mass fraction of 20%. liquid. The above spinning solution was used for electrospinning. Set the electrospinning process parameters as follows: the distance between the spinneret and the receiving plate is 20cm, the flow rate of the spinning solution is 0.8ml / h, the applied voltage is 20kV, and the aluminum foil is received for 16h to obtain PU / PCL / TiO 2 Composite nanofiber membrane.

[0046] 2. Acetobacter xylinum was used as the strain for culturing the bacterial cellulose membrane, and 1.5 g of tryptone, 2.5 g of yeast powder and 12.5 g of mannitol were accurately weighed, and dissolved in 1 L of distilled water to obtain a bacter...

Embodiment 3

[0051] 1. Accurately weigh 3.42g of polyurethane (PU) masterbatch, 0.38g of polycaprolactone (PCL) and 0.266g of TiO 2 Nanoparticles, dissolved in 16.2g N, N-dimethylformamide (DMF), stirred with a magnetic stirrer at room temperature until the polyurethane and polycaprolactone were completely dissolved to obtain a uniform and stable spinning with a mass fraction of 19%. silk liquid. The above spinning solution was used for electrospinning. Set the electrospinning process parameters as follows: the distance between the spinneret and the receiving plate is 18cm, the flow rate of the spinning solution is 0.6ml / h, the applied voltage is 18kV, and the aluminum foil is received for 12h to obtain PU / PCL / TiO 2 Composite nanofiber membrane.

[0052] 2. Acetobacter xylinum was used as the strain for culturing the bacterial cellulose membrane, and 1.5 g of tryptone, 2.5 g of yeast powder and 12.5 g of mannitol were accurately weighed, and dissolved in 1 L of distilled water to obtain ...

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Abstract

The invention provides an antibacterial elastic composite medical dressing and a preparation method thereof. The preparation method comprises the steps that firstly, a polyurethane / polycaprolactone / titanium dioxide composite nanofiber membrane is prepared through an electrostatic spinning technology, and then the composite nanofiber membrane is placed in a bacterial cellulose culture medium to be subjected to biological composite fermentation culture, then, the composite nanofiber membrane subjected to biological composite fermentation is sequentially subjected to alkali liquor soaking, washing and impurity removal, polycaprolactone melting and bonding, freeze drying, sterilization and loading of recombinant human epidermal cell growth factors, and the antibacterial elastic composite medical dressing is prepared. The composite medical dressing is simple in preparation process and controllable in production process, is a medical dressing with certain flexibility, and provides a carrier with excellent mechanical properties for subsequent preparation of functional wound dressings for resisting bacteria, promoting healing and the like.

Description

technical field [0001] The invention relates to the technical field of medical dressings, in particular to an antibacterial elastic composite medical dressing and a preparation method thereof. Background technique [0002] Skin organs in the human body have multiple physiological functions such as sensation, absorption, excretion and immunity. When the skin tissue is traumatized to a certain extent, the human body will be invaded by foreign substances and lose water, which will affect the function of the limbs. If certain protection measures are not taken for the wound, the exposure of the wound will cause infection, inflammation and some foreign substances. Complications follow. Skin dressings can effectively protect the wound from external substances, effectively prevent water evaporation, prevent bacterial infection, and promote wound healing. At present, the common medical dressings include various polymer films, hydrogels, sponges, alginates and other materials. The p...

Claims

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Application Information

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IPC IPC(8): A61L15/28A61L15/18A61L15/26A61L15/46A61L15/42D04H1/4382D04H1/728
CPCA61L15/26A61L15/18A61L15/28A61L15/46A61L15/42D04H1/728D04H1/4382A61L2400/12A61L2300/102A61L2300/404C08L75/04C08L67/04C08L1/02
Inventor 武丁胜凤权李曼魏安静刘晨徐宏光陶云周堂赵磊
Owner ANHUI UNIVERSITY OF TECHNOLOGY AND SCIENCE
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