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The preparation method of glycine

A technology of glycine and catalyst, applied in the field of preparation of glycine, can solve the problems of toxic environmental impact of raw materials, consumption of metered acid and alkali, large environmental impact, etc., and achieves the effects of green and clean reaction route, promotion of oxidation reaction, and low cost of raw materials

Active Publication Date: 2022-06-21
DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In order to solve the outstanding problems of raw material toxicity, high environmental impact and poor safety in the traditional preparation method of glycine, the dehydrogenation of ethanolamine to glycine needs to consume metered acid and alkali, high raw material consumption, and large environmental impact. The method for preparing glycine by oxidation has the advantages of green and clean reaction route, low raw material cost, high conversion rate and product selectivity, and recyclable catalyst.

Method used

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  • The preparation method of glycine
  • The preparation method of glycine
  • The preparation method of glycine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Dissolve 1 g of hydrated cobalt acetate in 100 ml of methanol, add 100 ml of methanol dissolved in 2 g of benzimidazole under stirring, continue to stir for 2 h, add 5 g of NaY molecular sieve, stir at 60 °C for 4 h, evaporate the solvent, and dry the obtained solid at 80 °C for 2 h Roast at 600 °C for 2 h under nitrogen protection to obtain nitrogen-doped carbon / NaY molecular sieve-supported cobalt catalyst (Co-N-C / NaY). Take 20 mg of the catalyst and add it to a 50 mL reaction kettle containing 2 g of ethanolamine and 8 g of deionized water, and stir. , heated to 100°C, filled with oxygen to a pressure of 1.0MPa, reacted for 8h, qualitatively and quantitatively analyzed the reaction product by gas chromatography-mass spectrometry, the conversion rate of ethanolamine was 99%, and the selectivity of glycine was 99%.

Embodiment 2-11

[0042] Examples 2-11 have studied the effect of different catalysts, and the specific procedures are similar to those of Example 1, except that different metal sources and different solid bases or metal oxide supports are used, and the catalysts are prepared at different temperatures. The calcination time is different, and other reaction conditions are the same as those in Example 1. The results are shown in Table 1.

Embodiment 2

[0043] The difference between embodiment 2 and embodiment 1 is: the metal source is 0.6g chloroauric acid; the solid base is 10g Mg(OH) 2 ; calcined at 500 °C for 3 h; finally, nitrogen-doped carbon / magnesium hydroxide supported gold catalyst (Au-N-C / Mg(OH) 2 ).

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Abstract

The application discloses a preparation method of glycine. The preparation method includes contacting the material containing ethanolamine and water with a catalyst in the presence of an oxygen source to react to obtain glycine; wherein, the catalyst is a metal catalyst loaded on a carrier; the carrier is a nitrogen-doped Carbon / solid base carrier; the catalyst is prepared by nitrogen-containing organic compound, solid base and metal source. The method for preparing glycine by direct catalytic oxidation of ethanolamine provided by the application has the advantages of green and clean reaction route, low raw material cost, high conversion rate and product selectivity, and recyclable catalyst.

Description

technical field [0001] The application relates to a preparation method of glycine, which belongs to the technical field of organic chemical industry. Background technique [0002] Glycine, also known as amino acetic acid, is an important organic chemical raw material. It is an edible spice allowed by my country's "National Food Safety Standard for the Use of Food Additives" (GB 2760), and is also used in medicine, feed and food as preservatives and food additives. Antioxidant, used in the pharmaceutical industry to treat myasthenia gravis and progressive muscle atrophy, hyperacidity, chronic enteritis, hyperprolinemia in children and other diseases, and also used to synthesize L-dopa, vitamin B6, threonine Acids, cephalosporins, thiamphenicol, delapril hydrochloride, aspirin calcium glyphosate, paracetamol glycinate, monoglycine acetylsalicylate calcium, reseramine and other medicines, as well as insecticides pyrethroids, fungicides isotope Bacteriocide, herbicide glyphosate, ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C227/02C07C229/08
CPCC07C227/02C07C229/08Y02P20/584
Inventor 黄义争高进徐杰孙颖苗虹车鹏华石松马红
Owner DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI