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Nano-silver-loaded Cu-MOF antibacterial material as well as preparation method and application thereof

A nanomaterial and antibacterial material technology is applied in the field of nano-silver-loaded Cu-MOF antibacterial material and its preparation, which can solve the problems of complex manufacturing process, strong organic toxicity, short antibacterial cycle, etc., and achieves good uniformity and stable adsorption capacity. , the effect of enhancing the antibacterial effect

Inactive Publication Date: 2021-06-11
XINXIANG HUAXI MEDICAL SANITARY MATERIALS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Organic antibacterial agents mainly include compounds such as quaternary ammonium salts, biguanides, and ethanol, which have the advantages of complete types, wide application, and remarkable bactericidal effect, but have the disadvantages of strong toxicity, poor heat resistance, and easy decomposition of some organic substances; inorganic antibacterial agents are generally listed as Silver, zinc, copper and other metal ions are the main raw materials, which have the characteristics of good high temperature resistance, short sterilization time and good sterilization effect, but some products have complicated manufacturing process, high cost, and some have defects such as poor stability and short antibacterial cycle

Method used

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  • Nano-silver-loaded Cu-MOF antibacterial material as well as preparation method and application thereof
  • Nano-silver-loaded Cu-MOF antibacterial material as well as preparation method and application thereof
  • Nano-silver-loaded Cu-MOF antibacterial material as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Example 1 The specific methods and steps for the synthesis of Cu-MOF and the modification of silver nanoparticles are as follows

[0038] The synthesis steps of the multifunctional organic ligand Cu-MOF are as follows: Cu(NO 3 ) 2 2.5H 2 O (732.7mg, 3.15mmol) and 3-amino-5-mercapto-1,2,4-triazole (522.6mg, 4.5mmol) (purchased from Aladdin CAS: 16691-43-3, the raw material was directly use) placed in 100mL (DMF / C2 h 6 O=1:1v / v) in a mixed solvent, heated at 120°C for 12h. After centrifugation, the pellet was washed repeatedly with ethanol and DMF, and heated under vacuum at 120 °C for 24 h. The yield of the obtained product Cu-MOF is above 98% based on ketone.

[0039] The synthesis steps of Ag nanoparticles-coated Cu-MOF are as follows:

[0040] Add 50 mg of the resulting product Cu-MOF to the AgNO-containing 3 (1mmol / L) in 10mL solution (DMF / C 2 h 6 O=1:1v / v), and stirred for 2.5h in the dark. The resulting suspension was centrifuged and washed with ethanol. ...

Embodiment 2

[0041] Example 2 Characterization of Cu-MOF nanomaterials coated with Ag nanoparticles

[0042] Take 5mg of Cu-MOF@Ag in an EP tube, add 20mL of deionized water to dilute, and sonicate for 30min. Take 5 μL and drop it on the silicon wafer and copper grid, and observe it under the scanning electron microscope and transmission electron microscope. The morphology and element distribution of Cu-MOF@Ag nanomaterials are as follows: figure 1 and figure 2 as shown, figure 1 Figure a shows the low-magnification SEM characterization of Cu-MOF, and picture b shows the high-magnification SEM characterization of Cu-MOF. exist figure 1 Among them, Cu-MOF is a spherical particle with a particle size of 500-800nm.

[0043] figure 2 The picture in middle a shows the high-magnification TEM of Cu-MOF@Ag, and the lattice fringes of the MOF structure can be seen. Figure b shows the electron diffraction of Cu-MOF@Ag, indicating that Cu-MOF@Ag has a good crystal structure. Figure c is the...

Embodiment 3

[0044] Example 3 Study on Catalytic Performance of Cu-MOF Nanomaterials Coated with Ag Nanoparticles

[0045] The oxidative enzyme-like properties of Ag nanoparticles-coated Cu-MOF nanomaterials can be verified by TMB color reaction, and the color change of TMB can be verified by the change of absorbance at 652 nm.

[0046] Add 100 μl of Cu-MOF@Ag, TMB and the mixture of Cu-MOF@Ag and TMB to the quartz cuvette respectively, and then measure its ultraviolet absorption spectrum at 400-800nm. image 3 The upper left figure of the above shows that the Cu-MOF nanomaterials coated with Ag nanoparticles can oxidize TMB, which makes TMB color and produce an obvious absorption peak at 652nm.

[0047] The absorbance is monitored by the kinetic mode of the UV monitor, and according to the kinetic equation of the enzymatic reaction, that is, the Michaelis-Menten equation, the kinetic data of the enzymatic reaction can be calculated, V 0 =(Vmax×[S]) / (Km+[S]), where V 0 is the initial rea...

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Abstract

The invention discloses a preparation method of a Cu-MOF@Ag nano material. An organic ligand containing an active functional group is used for replacing a connector in the synthesis process of MOF, and compared with organic functional modification on the surface of the MOF after synthesis of the MOF, the prepared MOF has the advantages that the number of active surface sites is increased, the durability of active sites on the surface is better, and the adsorption capacity on metal ions is more stable. The Cu-MOF and the silver nanoparticles are utilized to achieve the synergistic antibacterial effect, and compared with a traditional single antibacterial material, the antibacterial effect is greatly improved.

Description

technical field [0001] The invention relates to the field of antibacterial materials, in particular to a Cu-MOF antibacterial material loaded with nano silver and its preparation method and application. Background technique [0002] In recent years, drug-resistant bacterial infections have continued to increase, especially the incidence of multi-drug-resistant bacteria and extensively drug-resistant bacteria with limited treatment options, resulting in prolonged disease duration, prolonged hospital stay and higher risk of death for some patients. Increased family burden. Bacterial drug resistance has become a major public health threat in my country and even in the world. Therefore, the development of new functional materials with high antibacterial and anti-infective properties is of great strategic significance for protecting wounds, treating drug-resistant bacterial infections and improving patient survival. [0003] Silver ions are highly bactericidal, and its bacteric...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N59/16A01N25/10A01N25/26A01P1/00A41D13/11A41D31/30A41D13/00D06M15/37D06M11/83C08G83/00
CPCA01N59/16A01N25/10A01N25/26A41D13/1192A41D31/30A41D13/00D06M15/37D06M11/83D06M16/00C08G83/008
Inventor 崔文波
Owner XINXIANG HUAXI MEDICAL SANITARY MATERIALS
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