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Local-medicine-applying medicine composition including puerarin, brinzolamide and the like

A technology for topical administration and composition, applied in the field of pharmaceutical compositions such as glazolamide for topical administration, can solve the problems of rapid recovery of unfavorable conditions, prolonged treatment time, poor medication compliance, etc., and achieve inhibition or treatment or improvement. The effect of conjunctival hemorrhage symptoms, reducing adverse reactions, and reducing drug costs

Pending Publication Date: 2021-06-18
刘力
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to factors such as the long course of glaucoma and complicated treatment, some glaucoma patients may not be able to strictly follow the doctor's prescription for medication, and the medication compliance is poor, which directly affects the treatment effect and prolongs the treatment time, which is not conducive to the rapid recovery of the disease.
The single strategy model of the above drugs in the treatment of glaucoma still has deficiencies

Method used

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  • Local-medicine-applying medicine composition including puerarin, brinzolamide and the like
  • Local-medicine-applying medicine composition including puerarin, brinzolamide and the like

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preparation example Construction

[0112] In the preparation process of each embodiment of the present invention, in the case where the prescription of the embodiment has defined the names of the components, for the sake of simplicity, the names of the components in the prescription can be simplified or omitted. For example, "puerarin monohydrate", "edetate disodium dihydrate", etc., after the prescription components appear, they can be referred to simply as "puerarin", "edetate disodium" and so on.

[0113] Concentration units used in the description of the present invention have molar concentration (M) or (mol / L) or equivalent concentration (N), or percentage concentration etc., time unit can use second (s), minute (min), hour (h) Etc., volume unit can use liter (l or L), milliliter (ml), microliter (μl), mass unit can use gram (g), milligram (mg) and so on.

[0114] The appropriate amount in "appropriate amount of water for injection", "appropriate amount of sodium chloride" and the like all refer to the app...

Embodiment 1

[0118] The preparation of embodiment 1 compound catiolol puerarin in situ gel eye drops

[0119] Prescription: Carteolol hydrochloride 10g, puerarin monohydrate 10g, poloxamer 407 20g, methylcellulose 5g, polyethylene glycol 400 10g, trehalose 10g, glycerin 20g, methionine 3g, edetate di 0.3g of sodium, 0.01g of polyammonium chloride, appropriate amount of 2M citric acid solution and 2M sodium hydroxide solution, and dilute the volume to 1000ml with water for injection.

[0120] Preparation process: Weigh poloxamer 407, glycerin, polyethylene glycol 400, and methylcellulose in the prescribed amount, place them in a beaker of 850ml water for injection, stir to dissolve, and take the prescribed amount of polimonium chloride and hydrochloric acid respectively. Put carteolol, puerarin monohydrate, methionine, and trehalose in a beaker, stir to dissolve, adjust the pH of the solution to 6.8 with an appropriate amount of citric acid solution and sodium hydroxide solution, add water ...

Embodiment 2

[0121] The preparation of embodiment 2 compound dorzolamide puerarin gel eye drops

[0122] Prescription: dorzolamide 20g, puerarin monohydrate 2.5g, carbomer 940 5g, polyvinyl alcohol 12g, mannitol 8g, trehalose 3g, glycerin 5g, sodium sulfobutylbeta cyclodextrin 10g, cattle Sulfonic acid 5g, benzalkonium bromide 0.01g, edetate disodium dihydrate 0.2g, Tween-80 3g, appropriate amount of 2M citric acid solution and 2M sodium hydroxide solution, dilute to 1000g with water for injection.

[0123] Preparation process: Take the prescribed amount of Carbomer 940 and polyvinyl alcohol in a beaker, add about 850ml of water, let it stand still to make it swell, adjust the pH value to about 6.8 with an appropriate amount of citric acid solution and sodium hydroxide, and obtain the matrix. Edetate disodium dihydrate, sulfobutylbeta cyclodextrin sodium, mannitol, glycerin, dorzolamide, puerarin monohydrate, trehalose, taurine, benzalkonium bromide, Add water at temperature -80 and stir ...

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Abstract

The invention provides a medicine composition containing an effective dosage of puerarin and an effective dosage of dorzolamide or brinzolamide or prostaglandin, such as latanoprost, tafluprost and the like or / and an effective dosage of water-retaining agent or wetting agent or antixerophthalmic ingredients, and application in preparation of medicines, including eye-purpose medicines used for preventing or treating intraocular pressure or elevated intraocular pressure, glaucoma, fundi diseases, optic nerve protection, dry eyes or xerophthalmia or dry eye syndromes of the human being or mammals. The medicine disclosed by the invention has a better curative effect or a smaller side effect or better treatment compliance or a better treatment mode.

Description

technical field [0001] The present invention relates to the technical field of medicine, in particular to provide prevention or treatment of increased intraocular pressure, glaucoma, fundus diseases, such as retinal arteriovenous occlusion, optic atrophy, dry eye disease, protection of optic nerve, treatment of inflammatory skin diseases, etc. and Effective dose of puerarin or its pharmaceutically acceptable salt or its solvate and effective dose of dorzolamide or brinzolamide or prostaglandins such as latanoprost, tafluprost etc. or its pharmaceutically acceptable Pharmaceutical compositions and uses of salts and the like. Background technique [0002] Glaucoma (glaucoma) is a group of optic nerve diseases, including the loss of retinal ganglion cells. It is the second most blind eye disease in the world. If it is not treated in time, it will cause visual field defect or complete loss, leading to blindness. It is the most important cause of irreversible blindness. reason. ...

Claims

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Application Information

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IPC IPC(8): A61K45/06A61K31/352A61K31/382A61K31/542A61K31/5377A61K31/5575A61P27/06A61P27/02
CPCA61K45/06A61K31/352A61K31/382A61K31/542A61K31/5377A61K31/5575A61P27/06A61P27/02A61K2300/00
Inventor 刘力胡梨芳
Owner 刘力
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