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Orientation material based on magnetic nanofibers as well as preparation method and application of orientation material

A technology of magnetic nano and oriented materials, applied in biochemical equipment and methods, fiber chemical characteristics, pharmaceutical formulations, etc., can solve the problems that oriented nanofibers do not have orientation structure design, cannot be flexibly adjusted and realized, etc. , to achieve low cell adhesion, good biocompatibility, and a wide range of sources

Inactive Publication Date: 2021-06-18
SUZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this technology is closely combined with electrospinning, and the oriented nanofibers formed by electrospinning do not have the orientation structure design, and cannot flexibly control the fiber orientation structure, and cannot realize the construction of orientation structures such as certain angles, gradients, and radial patterns.

Method used

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  • Orientation material based on magnetic nanofibers as well as preparation method and application of orientation material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0071] The magnetic nanofibers are prepared by electrostatic spinning method, including the following steps:

[0072] S1, prepare silk fibroin solution

[0073] (1) Silk degumm: Weigh 25.44g ~ 60G no water NA 2 CO 3 After dissolving in 12L, it is less than the boiling deionized water. After it is dissolved, 30 g to 60 g of a silk or silkworm cocoons are placed in which 15 to 120 min, after removal, the silkwater obtained by deionized water has been washed repeatedly after dehydration. No smooth and greasy feel, put it in a fume hood to dry overnight.

[0074] The above degreased method can also be used in urea delatizing, alkaline protease deprint, neutral soap delay, and tartaric acid degumctate.

[0075] (2) Silkin protein dissolution: 20 ml of 9 ~ 9.5 mol / L of the lithium bromide solution, rapidly dissolved on the magnetic agitator, then use the filter machine to filter 2 ~ 3 times, the delayed silk is immersed, with tin foil paper The sealing is carried out, and the dissolve...

Embodiment 2

[0118] Electrostatic spinning method is used to prepare magnetic nanofibers, including the following steps:

[0119] S1-S2 is the same as in Example 1, and the step S3 of Example 1 is omitted.

[0120] In S4, a 1% chloride solution was added to the silk fibroin solution, and the mixture was mixed and dissolved in 50% to 70% PEG-400 solution, formulated into a spinning liquid. The mass ratio between the ferrous chloride and silk venein protein is 1: 50 to 200.

[0121] The composite nanofibers are obtained by electrostatic spinning by electrostatic spinning, and the nanofibers are 0.06% h. 2 O 2 Soak the stirring in the solution, add 3 mol / L sodium hydroxide solution to adjust the pH to 11 to 13, warmed to 55 ° C, adjust the stirring speed of 60 rpm, and stop heating after stirring for 3 h, to obtain magnetin compound nanofibers. Dispersion, placing a beaker in an ultrasonic cleaning machine After 5 min, after 20 min, these magnetic nanofibers gathered at the bottom of the beaker...

Embodiment 3

[0125] Electrostatic spinning method is three-step preparation of magnetic nanofibers, including the following steps:

[0126] S1-S3 is the same as in Example 1.

[0127] Different from one step, the magnetic nanoparticles prepared in step S3 are not added in S4.

[0128] The electrospun nanofibers formed in S5 were incubated in a suspension containing magnetic nanoparticles (10 ~ 50% V: V) for more than 3 hours, so as to adsorb the silk fibers and magnetic nanoparticles by electrostatic adsorption. The interaction, the chemical crosslinking is sufficiently bonded, and then centrifuged with a 25000 r / min at high speed centrifuge, and the centrifugal washing was repeated three times to obtain a magnetin-composite nanofiber.

[0129] S6-S9 is the same as in Example 1.

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Abstract

The invention relates to an orientation material based on magnetic nanofibers and a preparation method and an application of the orientation material based on the magnetic nanofibers, a magnetic nanomaterial and a nanofiber material are combined, a mixed solution is cross-linked in a magnetic field and is induced by the magnetic field to form orientation gel, and the orientation material based on the magnetic nanofibers is obtained. The magnetic field is utilized to pretreat the magnetic nanofibers in the gel forming matrix to form the preset orientation structure, then the gel forming matrix is crosslinked and cured to fix the preset orientation structure, the prepared orientation material can be used for studying the relationship between material properties and cell behaviors under the nanometer-micrometer-macroscopic scale, and the regulation and control mechanism of the material on cell behaviors is disclosed.

Description

Technical field [0001] The present invention relates to the field of functional materials, and more particularly to a magnetic nanofiber-based orientation material and a preparation method thereof. Background technique [0002] The extracellular matrix (ECM) is a core element of the bionic structure constructed. ECM not only serves as structural support, but also provides biochemical substances (such as growth factor and surface chemistry) and biological physical clues (such as fiber structure, hydrophilicity and viscous), and is responsible for regulating the diffusion of soluble factors, mediate cells and microenvironments. Mechanical performance signal transmission, regulatory cellular behavior from a multi-factor such as biological, biochemical and biological physics. Natural extracellular matrix has highly oriented characteristics in tissues of nerves, cornea, heart and tendon. In order to simulate the fiber structure of the natural extracellular matrix, more and more studie...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/28C08J3/24C12N5/00A61L27/52A61L27/22A61L27/18A61L27/02D01F4/00D01F1/10C08L89/00
CPCC08J3/28C08J3/246C12N5/00A61L27/227A61L27/18A61L27/025A61L27/52D01F4/00D01F1/10C12N2501/998A61L2400/12C08J2389/00C08J2489/00C08L89/00C08L71/02
Inventor 吴佳阳陈莉郑兆柱关晋平赵伟李刚王晓沁
Owner SUZHOU UNIV
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