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Radix sophorae subporstratae flavonoid pharmaceutical composition for treating mycoplasma pneumonia

A mycoplasma pneumonia and composition technology, which is applied in the direction of drug combination, medical preparations containing active ingredients, antibacterial drugs, etc., can solve the problems of drug resistance in the human body, inability to completely clear the ice sheet, etc., and achieve low viscosity and fluidity Good, the effect of increasing the contact area

Inactive Publication Date: 2021-08-06
GUANGXI BOTANICAL GARDEN OF MEDICINAL PLANTS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, azithromycin is often used for treatment in the existing technology. This kind of antibiotic treatment cannot completely clear the ice sheet, and it is easy to make the human body develop drug resistance.

Method used

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  • Radix sophorae subporstratae flavonoid pharmaceutical composition for treating mycoplasma pneumonia
  • Radix sophorae subporstratae flavonoid pharmaceutical composition for treating mycoplasma pneumonia
  • Radix sophorae subporstratae flavonoid pharmaceutical composition for treating mycoplasma pneumonia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] A pharmaceutical composition, comprising: 100 parts of flavonoid extracts from bean root, 2 parts of platycodon saponins, 2 parts of coptisine, and 2 parts of limpetine chloride;

[0023] Wherein, the flavonoids extract of bean root adopts conventional reflux extraction method, and is prepared as follows:

[0024] Weigh 5 g of mountain bean root powder, add 80 mL of 70% ethanol, heat and reflux for extraction for 2 hours, then filter, and take the filtrate to obtain the extract; pass the extract through a 0.45 μm filter membrane, elute, and concentrate the eluate by rotary evaporation to obtain Soba root flavonoids extract; the elution process is specifically, use the pretreated D101 macroporous resin to load the sample, after the adsorption equilibrium, first deionized water elution and then 90% ethanol elution, after obtaining the eluent, in Rotary evaporation at 45°C followed by concentration; the volume ratio of the resin bed volume, the deionized water, and the 90%...

Embodiment 2

[0027] A pharmaceutical composition, comprising: 100 parts of flavonoid extracts from bean root, 5 parts of platycodon saponins, 5 parts of berberine, and 5 parts of acanthine chloride;

[0028] Wherein, the flavonoids extract of bean root adopts ultrasonic extraction method, and is prepared as follows:

[0029] Weigh 5 g of mountain bean root powder, put it in an ultrasonic instrument, add 80 mL of 70% ethanol, and filter it after ultrasonic extraction for 30 minutes, and the filtrate is the extract; pass the extract through a 0.45 μm filter membrane, elute, and eluate Concentrate by rotary evaporation to obtain the flavonoids extract of bean root; the elution process is specifically, use the pretreated D101 macroporous resin to load the sample, after the adsorption equilibrium, first elute with deionized water and then with 90% ethanol to obtain The eluate was then concentrated by rotary evaporation at 45°C; the volume ratio of the resin bed volume, the deionized water, and ...

Embodiment 3

[0032] A pharmaceutical composition, comprising: 100 parts of flavonoid extracts from bean root, 3 parts of platycodon saponins, 4 parts of coptisine, and 3 parts of limpetine chloride;

[0033] Wherein, the flavonoids extract of bean root is prepared as follows:

[0034] S1. Take the root slices of the mountain bean root and crush them through a 40-mesh sieve and soak them in ethanol with a volume fraction of 65% for 22 hours. After suction filtration, take the filter residue and dry it at 85° C. for 24 hours to obtain the root root of the mountain root;

[0035] S2. Add the root powder and enzyme to the extraction solvent in sequence, stir evenly, react at 40°C for 30 minutes, and then filter to obtain the enzymolysis solution and residue; the root powder, the enzyme, the extraction The weight ratio of the solvent is 100:1.3:450, the enzyme is cellulase or pectinase; the extraction solvent is ethanol with a volume fraction of 70%;

[0036] S3. Put the enzymolysis residue in...

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Abstract

The invention discloses a pharmaceutical composition. The pharmaceutical composition comprises 100 parts of radix sophorae subporstratae flavonoid extract, 2-5 parts of platycodin, 2-5 parts of coptisine and 2-5 parts of chlorinated nitidine. The invention further discloses use of the pharmaceutical composition in preparation of drugs for treating mycoplasma pneumonia. The pharmaceutical composition disclosed by the invention can be used for effectively inhibiting propagation of mycoplasma pneumoniae in lung tissue on one hand, can also be used for lowering expression levels of inflammatory factors TNF-alpha and IL-6 on the other hand, globally alleviating inflammatory reactions caused after mycoplasma pneumoniae infection and thus provides a new way of think for treatment on the mycoplasma pneumonia.

Description

technical field [0001] The invention relates to the field of medicine preparation. More specifically, the present invention relates to a kind of flavonoid pharmaceutical composition of bean root for the treatment of mycoplasma pneumonia. Background technique [0002] Mycoplasma pneumonia is an acute pulmonary infectious disease caused by Mycoplasma pneumoniae, mainly characterized by bronchi and interstitial lesions, often accompanied by pharyngitis and bronchitis. Mycoplasma pneumoniae is a "pleuropneumonia-like microorganism" between bacteria and viruses. After infection, it will cause multi-system immune damage, and will cause concurrent infection of other diseases, repeated attacks of Mycoplasma pneumoniae pneumonia, and difficult to cure. Severe cases may lead to disease. son died. At present, azithromycin is often used for treatment in the prior art. This kind of antibiotic treatment cannot completely clear the ice sheet, and it is easy to make the human body develop...

Claims

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Application Information

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IPC IPC(8): A61K36/489A61P11/00A61P31/04A61K31/4375A61K31/4741A61K31/704
CPCA61K31/4375A61K31/4741A61K31/704A61K36/489A61K2236/19A61K2236/333A61K2236/39A61P11/00A61P31/04A61K2300/00
Inventor 王硕龚小妹莫单丹欧春丽周小雷缪剑华
Owner GUANGXI BOTANICAL GARDEN OF MEDICINAL PLANTS
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