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Degradable shape memory polymer, preparation method and application thereof, and 4D printing degradable inferior vena cava filter

A technology of memory polymer and vena cava, which is applied in the fields of medical formula, drug delivery, medical science, etc., can solve the problems of inferior vena cava perforation, increase the economic burden of patients, and radiation exposure of surgeons, and achieve enhanced mechanical properties and good biological properties. Excellent compatibility and biodegradability

Active Publication Date: 2021-10-15
LANZHOU INST OF CHEM PHYSICS CHINESE ACAD OF SCI +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since the inferior vena cava filter entered the stage of interventional therapy, it has experienced step-by-step improvements in permanent filters, temporary filters, and recyclable filters. However, the inferior vena cava filters currently in clinical use are mainly made of nickel-titanium alloy and other metal materials. , long-term indwelling in the body can lead to severe complications such as filter rupture, displacement, embolism, and symptomatic inferior vena cava perforation, and the filter needs to be removed again through interventional surgery, which increases the economic burden of the patient and the radiation exposure of the surgeon. The application has entered the bottleneck stage, and biodegradable filters that do not need to be removed by surgery have become a research hotspot
However, there is no mature biodegradable inferior vena cava filter applied to the human body

Method used

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  • Degradable shape memory polymer, preparation method and application thereof, and 4D printing degradable inferior vena cava filter
  • Degradable shape memory polymer, preparation method and application thereof, and 4D printing degradable inferior vena cava filter
  • Degradable shape memory polymer, preparation method and application thereof, and 4D printing degradable inferior vena cava filter

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preparation example Construction

[0039] The present invention provides a preparation method of the degradable shape memory polymer described in the above technical solution, comprising the following steps:

[0040] Mix polyglyceryl sebacate acrylate, hydroxyethyl methacrylate and a photoinitiator, and carry out crosslinking reaction under light conditions to obtain a degradable shape memory polymer.

[0041] The invention mixes polyglyceryl sebacate acrylate, hydroxyethyl methacrylate and photoinitiator. In the present invention, the mass ratio of polyglyceryl sebacate acrylate to hydroxyethyl methacrylate is preferably 1:1˜7:3, more preferably 1.2:1.

[0042] In the present invention, the polyglyceryl sebacate acrylate has a structure shown in formula 1:

[0043] Formula 1; the number average molecular weight of the polyglyceryl sebacate acrylate is 1900-5100 Da.

[0044] In the present invention, the preparation method of described polyglyceryl sebacate acrylate preferably comprises the following steps: ...

Embodiment 1

[0082] Take by weighing 21g glycerol (glycerol) and 46.1g sebacic acid and add in the there-necked flask, adopt magnetic stirring, N 2 Under protection, carry out the polymerization reaction at 120°C for 24 hours, and use a water separator and a condenser to remove moisture;

[0083] Remove water separator and condenser tube and N 2 Atmosphere, connect the vacuum pump, set the vacuum degree to be-800mbar, and continue to polymerize for 24h to obtain a light yellow viscous PGS polymer (light yellow waxy at room temperature), and the measured number average molecular weight is 3570Da;

[0084] Add 25g PGS polymkeric substance and 250mL methylene dichloride in the there-necked flask, make the mass concentration of gained polyglyceryl sebacate solution be 10%, under N 2 Add 9.9166g of triethylamine under protection, and then magnetically stir for 30min in an ice bath at 4°C to obtain a mixed solution; add 8.869g of acryloyl chloride dropwise to the mixed solution, and continue to...

Embodiment 2

[0088] Take by weighing 21g glycerol (glycerol) and 46.1g sebacic acid and add in the there-necked flask, adopt magnetic stirring, N 2 Under protection, carry out the polymerization reaction at 120°C for 24 hours, and use a water separator and a condenser to remove moisture;

[0089] Remove water separator and condenser tube and N 2 atmosphere, connect the vacuum pump, set the vacuum degree to be-800mbar, and continue to polymerize for 12h to obtain a light yellow viscous PGS polymer (light yellow waxy at room temperature), and the number average molecular weight recorded is 1953Da; and according to the modification of Example 1 The PGSA polymer is prepared by acrylation reaction by a unique method;

[0090] Get 10g PGSA and mix with 5.385g hydroxyethyl methacrylate (mass percentage 65%: 35%), add 307mg photoinitiator DMPA (by mass percentage 2%) and mix uniformly, at wavelength 365nm, intensity 10mW / cm 2 Under the irradiation of ultraviolet light, the crosslinking reaction ...

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Abstract

The invention provides a degradable shape memory polymer, a preparation method and application thereof and a 4D printing degradable inferior vena cava filter, and belongs to the technical field of implantable medical instruments. In the shape memory polymer provided by the invention, a polysebacic acid glyceride structural part has an aliphatic long carbon chain structure, so that highd biocompatibility, biodegradability and high cell binding performance can be provided; a hydroxyethyl methylacrylate structure part provides mechanical support required by the inferior vena cava filter; and an acryloylated group enables the composite material to have photocuring performance. The shape memory polymer is used and combined with a 3D printing technology to prepare the 4D printing degradable inferior vena cava filter, and the 4D printing degradable inferior vena cava filter is biodegradable and has high biocompatibility, and the long-term patency rate of blood vessels is guaranteed; and the shape memory polymer has excellent mechanical properties and deformability, and can effectively intercept blood clots in a short period of time.

Description

technical field [0001] The invention relates to the technical field of implantable medical devices, in particular to a degradable shape memory polymer, a preparation method and application thereof, and a 4D printed degradable inferior vena cava filter. Background technique [0002] Deep vein thrombosis is a disorder of venous return caused by abnormal coagulation of blood in deep veins, which often occurs in the lower extremities. The shedding of emboli can cause pulmonary embolism, which has high morbidity and mortality worldwide. By inserting an inferior vena cava filter and using its mesh filter structure to capture blood clots, fatal pulmonary embolism can be prevented. Since the inferior vena cava filter entered the stage of interventional therapy, it has experienced step-by-step improvements in permanent filters, temporary filters, and recyclable filters. However, the inferior vena cava filters currently used in clinical practice are mainly made of nickel-titanium allo...

Claims

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Application Information

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IPC IPC(8): C08F283/01C08F220/20C08F2/48A61L31/04A61L31/14B33Y70/00
CPCC08F283/01C08F2/48A61L31/048A61L31/14A61L31/148B33Y70/00A61L2400/16C08F220/20C08L51/08
Inventor 张耀明屈睿升王齐华王廷梅周栋周晏仪刘宝坤
Owner LANZHOU INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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