A kind of coated stent and preparation method thereof
A coating and stent layer technology, applied in the field of medical devices, to prevent thrombosis, promote cell regeneration, and have no pollution to the environment
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Embodiment 1
[0021] like figure 1 , 2 As shown in Fig. 3, the coated stent of the present invention is in a network structure, and the constituent parts of the network structure are composed of three-layer structure, the inner layer is the stent layer, the middle layer is the anticoagulation modified layer, and the outermost layer is the nano-short film. Peptide coating; the inner layer of the stent network structure is composed of metal or polymer wires with a diameter of 0.01 mm; the diameter of the coated stent is 3.0 mm.
[0022] like image 3 , 4 As shown in the figure, the coated stent of the present invention is composed of a three-layer structure, the middle layer is an anticoagulation modified layer, and the anticoagulation modified layer is composed of heparin, polyethylene glycol, phosphorylcholine, hydroxyl One or more mixtures of ethyl cellulose, chitosan and its derivatives, and albumin; the thickness of the anticoagulant modified layer is 10 nm. The nano short peptide co...
Embodiment 2
[0026] right as figure 1 The coated stent shown is prepared by the following process: the stent network structure is woven by a knitting machine; first, oxygen plasma glow discharge treatment is performed on the processed stent network structure: the discharge power is 100W, and the treatment time is 30min, The oxygen flow rate is 500ml / min; the oxygen-treated stent is reacted with polyethylene glycol dicarboxylic acid; after the reaction is completed, the carboxyl group activation treatment is continued with N-hydroxysuccinimide and carbodiimide hydrochloride: The activated scaffold was then modified by plasma deposition of the anticoagulant substance phosphorylcholine: the plasma deposition temperature was 70°C, the glow discharge deposition time was 45min, and the discharge power was 300W. Finally, on the surface-modified anticoagulant modified layer, continuous spraying of short peptide RGD is carried out, so that the short peptide RGD reacts with part of the anticoagulant...
Embodiment 3
[0028] right as figure 1 The shown coated stent is prepared by the following process: the stent network structure is cut from a nickel-titanium tube; first, the processed stent network structure is subjected to oxygen plasma glow discharge treatment: the discharge power is 20W, and the treatment time is 30min, the oxygen flow rate is 100ml / min; react the oxygen-treated stent with polyacrylic acid; after the reaction is completed, continue to use N-hydroxysuccinimide and carbodiimide hydrochloride for carboxyl activation treatment: then activate The obtained stent was modified by plasma deposition of the anticoagulant substance heparin: the plasma deposition temperature was 105° C., the glow discharge deposition time was 20 min, and the discharge power was 200 W. Finally, on the surface-modified anticoagulant modified layer, continuous spraying of short peptide RADA-16 is continued, so that the short peptide RADA-16 reacts with part of the anticoagulant coating by covalent bond...
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Abstract
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