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Peelable ultrathin hydrogel as well as preparation method and application thereof

A hydrogel and peel-off technology, applied in the field of preparation, peelable ultra-thin hydrogel, can solve the problems of water loss, limited film size, difficulty in preparing hydrogel films, etc., achieve uniform distribution and prevent water loss , thickness controllable effect

Pending Publication Date: 2021-12-07
SHENZHEN GRADUATE SCHOOL TSINGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, these methods are not suitable for the preparation of ultra-thin and large-area hydrogel films. The defect is that when the hydrogel film is prepared by mold casting, the precision and size of the mold limit the thickness and preparation area of ​​the hydrogel film. It is difficult to prepare hydrogel films with a thickness of less than 100 μm, and the uniformity of the film cannot be controlled; although the spin-coating method can prepare ultra-thin hydrogels with a thickness of 10 μm, a large amount of water loss during the spin-coating process is not conducive to the stable shaping of the structure , and the resulting film has a finite size
[0005] In addition, since the hydrogel needs to be able to evenly level on the surface of the substrate during the preparation process, a relatively hydrophilic substrate is required, such as glass, quartz, or PET films with improved hydrophilicity after plasma treatment, resulting in the preparation of The hydrogel films are difficult to peel off from the substrate

Method used

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  • Peelable ultrathin hydrogel as well as preparation method and application thereof
  • Peelable ultrathin hydrogel as well as preparation method and application thereof
  • Peelable ultrathin hydrogel as well as preparation method and application thereof

Examples

Experimental program
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Embodiment 1

[0032] This embodiment adopts chemical cross-linking method to prepare hydrogel film:

[0033] Sodium alginate was dissolved in 6 mL of pure water to prepare a 1 wt % aqueous solution, stirred at room temperature for 4 h to dissolve, and stirred at 50° C. for 30 min to make it swell. Add 1 mL of acrylamide aqueous solution (concentration 10wt%) and stir for 10 minutes, then add 490 μL of cross-linking agent N,N'-methylene bisacrylamide (0.15wt%) aqueous solution, thermal initiator ammonium persulfate aqueous solution (concentration 5wt%) and stir 2h until evenly mixed to obtain a mixed solution.

[0034] Select two PET release films with a surface release force of 15-20g, a thickness of 25 μm and 75 μm, a length of 15 cm, and a width of 10 cm. One side of the two PET release films has been coated with silicone oil (this implementation The PET films adopted in the example are all purchased from Shanghai Huadong Composite Material Filter Cloth Screen Factory), and after cutting...

Embodiment 2

[0039] This embodiment adopts physical cross-linking method to prepare hydrogel film:

[0040] Soak 2g of gelatin in a mixed solvent of 9g glycerin and 3g pure water for 12h, stir at 70°C for 2h, and then put it in an oven at 90°C until all bubbles disappear.

[0041] Turn on the heating switch of the twin-roller coater (heating range 30-90°C), and heat the twin-rollers to 90°C to a steady state. Laminating machine structure and figure 1 Similar to the double-roller coater, only the double-roller adds heating function.

[0042] Pour 1 mL of the mixed solution while hot on the surface of a PET release film (purchased from Huahong Composite Materials Co., Ltd.) with a thickness of 100 μm, a length of 15 cm, and a width of 10 cm. The surface has been treated with silicone oil and the release force is 7-10 g. Another layer of PET release film with a thickness of 19 μm (release force 8-12g) surface treated with silicone oil (purchased from Shanghai Huadong Composite Filter Cloth ...

Embodiment 3

[0045] In this embodiment, the thickness of the untreated surface is 100 μm, and the area is 10×15cm 2 Two pieces of PVC film. 3M Novec 1700 and 3M Novec 7100 were formulated into a solution at a ratio of 1:7. After the plasma treatment was performed on the surface of the PVC film, the Novec solution was evenly coated on the surface with a four-sided coater. After the solvent evaporated, the solution of Example 1 The hydrogel stock solution prepared in is poured on the surface of PVC film and pressed by double rollers. After the reaction is completed, tear off the protective film to obtain a hydrogel film.

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Abstract

The invention discloses a peelable ultrathin hydrogel, a preparation method and an application. According to the invention, a simple double-roller coating machine is utilized to extrude the hydrogel smeared between the two layers of hydrophobic films, so that the peelable ultrathin hydrogel with adjustable thickness is successfully obtained. The hydrogel film prepared by the method disclosed by the invention can be easily and completely stripped from the surface of a hydrophobic film, and the minimum thickness can reach 10 microns. The preparation method disclosed by the invention is simple in equipment, easy to operate, relatively low in cost and relatively high in repeatability, has universality to different types of hydrogel, and provides a new thought for producing large-area ultrathin hydrogel. A super-breathable adhesive layer is applied to a flexible electronic device and a skin interface to serve as the super-breathable adhesive layer.

Description

technical field [0001] The invention relates to the field of hydrogel materials, in particular to a peelable ultra-thin hydrogel, a preparation method and application. Background technique [0002] Hydrogel is a material with a three-dimensional hydrophilic polymer network structure capable of absorbing and immobilizing large amounts of water. Because of its good biocompatibility and Young's modulus close to that of human tissue, it is widely used in the fields of biomedicine and cosmetics, including drug sustained release, tissue engineering, facial masks, etc. At the same time, due to its good permeability to oxygen and nutrients, it is widely used in wound dressings and contact lenses. [0003] In recent years, the rise of adhesive hydrogels has further expanded the application fields of hydrogels. The researchers developed hydrogels that can form stable chemical bonds with different substrates, and can even be applied to the wet surface of some human tissues, with extr...

Claims

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Application Information

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IPC IPC(8): C08J3/075C08J5/18C08L33/26C08L5/04C08L89/00C08K5/053C08F220/56C08F222/38
CPCC08J3/075C08J5/18C08F220/56C08J2333/26C08J2405/04C08J2389/00C08K5/053C08F222/385
Inventor 程思敏徐晓敏
Owner SHENZHEN GRADUATE SCHOOL TSINGHUA UNIV