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Ammonia borane/silicon sphere/mesoporous silica nano-composite particle, and preparation and application thereof

A technology of nanocomposite particles and mesoporous silica, applied in the direction of silica, silicon oxide, boron compound active ingredients, etc., can solve the problem of inability to remove CTAC well, lengthy synthesis process of composite particles, and influence on the formation of mesoporous structure To achieve the effect of shortening the preparation cycle, flexible and adjustable pore size distribution, and promoting nerve regeneration

Active Publication Date: 2021-12-17
EAST CHINA NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Yet, there is following technical problem in the technical scheme of this patent: 1) Fe 3 o 4 @SiO 2 @mSiO 2 The synthesis process of composite particles is lengthy, which is not conducive to the scale-up operation of industrialization
3) Mesoporous SiO 2 The adsorption capacity is limited, limiting the Fe 3 o 4 @SiO 2 @mSiO 2 Application of Composite Particles in Heavy Metal Adsorption in Water Treatment Technology
However, the technical solution of this patent has the following technical problems: 1) The particle size of AB@MSN nanomedicine is about 50nm, which is easily absorbed by the liver when injected into the body and cannot exert its own drug effect, so to a large extent Limiting medical applications; 2) Extracting the surfactant CTAC with ethanol solution of hydrochloric acid for a total of three times cannot remove CTAC well, further affecting the formation of mesoporous structure; 3) Whether hydrogen alone really has a good anticancer effect has been debated Questioning whether the observed suppression of cancer growth was due to other secondary factors remains to be investigated

Method used

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  • Ammonia borane/silicon sphere/mesoporous silica nano-composite particle, and preparation and application thereof
  • Ammonia borane/silicon sphere/mesoporous silica nano-composite particle, and preparation and application thereof
  • Ammonia borane/silicon sphere/mesoporous silica nano-composite particle, and preparation and application thereof

Examples

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Effect test

Embodiment 1

[0048] In this embodiment, ammonia borane / silica sphere / mesoporous silica nanocomposite particles (AB / SiO2 @mSiO 2 ), the composite structure nanoparticles are based on solid silicon spheres as the core and silicon oxide as the outer shell, and the template agent is removed by methanol to obtain mesoporous SiO 2 @mSiO 2 , and then loaded ammonia borane small molecule prodrug.

[0049] (1) The preparation method of this ammonia borane / silicon sphere / mesoporous silica nanocomposite particle comprises the following steps:

[0050] (1-1) Silicon dioxide dSiO 2 Preparation of nanoparticles: In a 100mL single-necked bottle, according to the measurement of the reaction process of tetraethyl orthosilicate and water, add 74mL of ethanol, 15mL of water and 3.2mL of ammonia water, stir at 30°C for 20min, then drop in 2.8mL Tetraethyl orthosilicate was hydrolyzed and polymerized, stirred in a water bath at 30°C for 2 hours, washed twice with centrifuged alcohol, washed once with water,...

Embodiment 2

[0068] The preparation method of ammonia borane / silicon sphere / mesoporous silica nanocomposite particle of the present embodiment is basically the same as that of embodiment 1, the difference is:

[0069] In step (1-1), the amount of tetraethyl orthosilicate added is 2.5 mL.

[0070] In step (1-2), the addition of triethanolamine (TEA) is 0.2g, and the monodisperse SiO dispersed in deionized water 2 The amount of nanoparticles added was 8 mL.

[0071] In step (1-3), the amount of methanol solution of 1% NaCl added is 40 mL.

[0072] In step (1-4), the addition of ammonia borane is 200mg, SiO 2 @mSiO 2 Composite nanoparticles are 1.5 mL.

[0073] The detection results and properties of the ammonia borane / silicon sphere / mesoporous silica nanocomposite particles obtained in Example 2 are basically the same as those in Example 1.

Embodiment 3

[0075] The preparation method of ammonia borane / silicon sphere / mesoporous silica nanocomposite particle of the present embodiment is basically the same as that of embodiment 1, the difference is:

[0076] In step (1-1), the addition of tetraethyl orthosilicate is 4.5 mL.

[0077] In step (1-2), the addition of cetyltrimethylammonium chloride is 1.5g, and the monodisperse SiO dispersed in deionized water 2 The amount of nanoparticles added was 15 mL.

[0078] In step (1-3), the amount of methanol solution of 1% NaCl added is 65 mL.

[0079] In step (1-4), the addition of ammonia borane is 300mg, SiO 2 @mSiO 2 Composite nanoparticles are 2.5 mL.

[0080] The detection results and properties of the ammonia borane / silicon sphere / mesoporous silica nanocomposite particles obtained in Example 3 are basically the same as those in Example 1.

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Abstract

The invention relates to an ammonia borane / silicon sphere / mesoporous silica nano-composite particle, and a preparation method and application thereof. The chemical formula of the nano-composite particle is AB / SiO2@mSiO2, the nano-composite particle takes a silicon dioxide sphere as a substrate and the mesoporous silica as a shell, and a gas prodrug capable of generating hydrogen in an acidic microenvironment is loaded. The nano composite particle is used as a drug carrier, is used for imaging diagnosis, gas therapy and inflammation resistance, synergistically enhances neurological function recovery, reduces fibrosis scar formation, and promotes nerve regeneration by inhibiting an oxidative stress response. Compared with the prior art, the AB / SiO2 (at) mSiO2 nano-composite particle has a novel structure, has a broad application prospect on the aspects of gas prodrug loading, gas controllable release, ultrasonic imaging and spinal cord injury diagnosis and treatment, can transmit gas prodrugs to injured lesion sites and performs diagnosis and real-time observation of treatment conditions through imaging, and can effectively and visually treat the spinal cord injury by comprehensively adjusting oxidation and inflammation imbalance in the microenvironment.

Description

technical field [0001] The invention belongs to the technical field of carriers for diagnosing and treating oxidative stress-related diseases, and relates to an ammonia borane / silicon sphere / mesoporous silica nanocomposite particle and its preparation and application. Background technique [0002] Spinal cord injury (SCI) is a kind of devastating central nervous system injury disease, which usually leads to refractory neurological dysfunction, loss of sensory and autonomic nerve functions to varying degrees, leading to paralysis, severe cases and even death. It has the characteristics of complex injuries, long treatment and nursing cycle, high cost of treatment, and poor clinical prognosis. Big burden. However, the incidence of SCI continues to increase with an aging population and increasing and widespread use of motor vehicles. Moreover, there is no effective prevention and treatment method at present, which is a major medical problem facing the world. Meanwhile, biogas...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/22A61K47/69A61K9/51A61K47/04A61P25/00A61P29/00B82Y5/00B82Y30/00B82Y40/00C01B6/13C01B33/12C01B33/18
CPCA61K33/22B82Y5/00B82Y30/00B82Y40/00A61P25/00A61P29/00A61K47/6923A61K9/5115C01B6/13C01B33/12C01B33/18C01P2004/04
Inventor 王烨颖王依婷刘毅王伟恒王镜闫志强俞磊
Owner EAST CHINA NORMAL UNIV
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