Wet adhesive super-lubricating hydrogel coating and preparation method thereof

A hydrogel and super-lubricating technology, applied in coatings, pharmaceutical formulations, catheters, etc., can solve the problems of hydrogel dehydration, uneven coating, insufficient adhesion, etc., to achieve strong adhesion, mechanical High intensity, pain relieving effect

Active Publication Date: 2022-03-22
FUZHOU UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For example, the Chinese patent with the publication number CN201911214849.8 discloses a hydrophilic lubricating coating, which has better mechanical robustness, but the adhesion is insufficient, which easily causes the coating to fall off
Another example is the Chinese patent whose publication number is CN202110691314.0, which discloses a hydrogel freeze-dried powder coating, which solves the problem of hydrogel

Method used

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  • Wet adhesive super-lubricating hydrogel coating and preparation method thereof
  • Wet adhesive super-lubricating hydrogel coating and preparation method thereof
  • Wet adhesive super-lubricating hydrogel coating and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] 5% ( W / V) Acrylamide monomer, 2% ( W / V) The sodium alginate powder was dissolved in deionized water, and the solution was evenly stirred for 18 h to mix completely to obtain solution A;

[0045] Add 0.01% ( W / V) cross-linking agent N,N' − Methylenebisacrylamide, 0.05% ( W / V) The cross-linking accelerator tetramethylethylenediamine, 0.1% ( W / V) The hydrophilic photoinitiator ammonium persulfate and 0.2% ( W / V) The ionic crosslinking agent calcium sulfate dihydrate, the stirring time is 6 h, mix well to obtain solution B;

[0046] Add the binder tannic acid to the solution B, stir well until the mixture is uniform, and then the pregel solution C can be obtained; the mass ratio of the added tannic acid to the hydrogel monomer contained in the solution B is 0.01 :100;

[0047] Immerse the catheter in the pregel solution C, take it out after 2 seconds, put it under ultraviolet light for 0.5 h, and then let it stand at room temperature for 12 h to complete the p...

Embodiment 2

[0049] 15% ( W / V ) of acrylamide monomer, 2% ( W / V ) Sodium alginate powder was dissolved in deionized water, and the solution was evenly stirred for 18 h to mix completely to obtain solution A;

[0050] Add 0.05% ( W / V ) of the cross-linking agent N,N' − Methylenebisacrylamide, 0.32% ( W / V ) of the cross-linking accelerator tetramethylethylenediamine, 0.13% ( W / V ) of the hydrophilic photoinitiator ammonium persulfate and 0.25% ( W / V ) ionic cross-linking agent calcium sulfate dihydrate, the stirring time is 6 h, mix well to obtain solution B;

[0051] Add the binder chitosan to the solution B, stir well until the mixture is uniform, and then the pregel solution C can be obtained; the mass ratio of the added chitosan to the hydrogel monomer contained in the solution B is 0.01 :100;

[0052] Immerse the catheter in the pregel solution C, take it out after 2 seconds, put it under ultraviolet light for 0.5 h, and then let it stand at room temperature for 12 h to co...

Embodiment 3

[0054] 30% ( W / V ) of acrylic monomer, 5% ( W / V ) Sodium alginate powder was dissolved in deionized water, and the solution was evenly stirred for 18 h to mix completely to obtain solution A;

[0055] Add 0.1% ( W / V ) of the cross-linking agent N,N' − Methylenebisacrylamide, 0.50% ( W / V ) of the cross-linking accelerator tetramethylethylenediamine, 0.15% ( W / V ) of the hydrophilic photoinitiator ammonium persulfate and 0.3% ( W / V ) ionic crosslinking agent calcium sulfate dihydrate, the stirring time is 24 h, mix well to obtain solution B;

[0056] Add the adhesive dopamine to the solution B, stir well until the mixture is uniform, and then the pre-gel solution C can be obtained; the mass ratio of the added dopamine to the hydrogel monomer contained in the solution B is 0.01:100;

[0057] Immerse the catheter in the pregel solution C, take it out after 2s, place it under ultraviolet light for 0.5 h, and then let it stand for 12 h to complete the polymerization. Af...

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Abstract

The invention provides a wet adhesion super-lubricating hydrogel coating and a preparation method thereof. The preparation method comprises the following steps: adding a hydrogel monomer and sodium alginate powder into deionized water, then sequentially adding a cross-linking agent N, N 'methylene bisacrylamide, a cross-linking accelerant tetramethylethylenediamine, a hydrophilic photoinitiator ammonium persulfate and an ionic cross-linking agent calcium sulfate dihydrate, then adding an adhesive, and uniformly mixing to obtain a pre-gel solution; and immersing a substrate in the pre-gel solution, taking out the substrate, placing the substrate at room temperature for illumination, and completing a polymerization reaction through photo-initiation to obtain the wet adhesion super-lubrication hydrogel coating. The obtained hydrogel has a double-network water structure, can effectively dissipate applied stress, is good in mechanical property, and effectively solves the problems of fracture and deformation caused by bending of a coating; meanwhile, good hydrophilicity and good adhesion are achieved. The hydrogel coating is convenient to use and rapid in film forming, and is expected to be applied to medical catheters, Foley catheters, cardiac pacemaker leads and large-scale soft robots.

Description

Technical field: [0001] The invention belongs to the field of medical devices, and in particular relates to a superlubricating hydrogel coating adhered in a wet state and a preparation method thereof. Background technique: [0002] Water lubrication exists widely in many anatomical parts of organisms, including respiratory tract, articular cartilage, internal organs and ocular surface. Good lubrication and low-friction movement play a vital role in maintaining the physiological functions of the human body. Therefore, low boundary friction to tissues is beneficial for medical device applications, but these medical devices usually do not have the ability to lubricate biological interfaces. According to the current study, the hydration layer formed on the underlying substrate is called aqueous lubrication. The confined water in the hydration layer is an important lubricant between sliding surfaces, and when subjected to shear force, the hydration layer can respond in a fluid-...

Claims

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Application Information

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IPC IPC(8): A61L29/14A61L29/08
CPCA61L29/145A61L29/14A61L29/085A61L2400/10C08L5/04C08L51/02
Inventor 张进刘燕芸杨黄浩
Owner FUZHOU UNIVERSITY
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