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Medical dressing capable of resisting bacteria and promoting wound healing

A technology for wound healing and chitosanization, applied in medical science, bandages, etc., can solve the problem of not finding soluble chitosan, and achieve the effect of promoting wound healing, good antibacterial properties, and antibacterial wound healing

Active Publication Date: 2022-03-25
TECHNICAL INST OF PHYSICS & CHEMISTRY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the application of PEG-modified soluble chitosan in the field of promoting infection or chronic wound healing has not yet been found.

Method used

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  • Medical dressing capable of resisting bacteria and promoting wound healing
  • Medical dressing capable of resisting bacteria and promoting wound healing
  • Medical dressing capable of resisting bacteria and promoting wound healing

Examples

Experimental program
Comparison scheme
Effect test

Synthetic example 1

[0044] Synthetic methoxy PEG chitosan

[0045] It is weighed with a chitosan of 0.16 g of a molecular weight of 2 × 10 ^ 5dA, and a deththyacetin is 95%, and a 10 ml MES buffer (25 mM, pH = 4.90), and stirred at 0.1 ml of HCl at room temperature for half an hour, The chitosan is completely dissolved, thereby obtaining a uniform solution having a mass volume percent concentration of 1.6%; then activated at room temperature for 1 hour carboxy polyethylene glycol monomethyl ether, NHS and EDC · HCl mixed solution (solvent is 25 mm pH) = 4.90 MES buffer solution) 20 mL of the reaction solution, continuously stirred at room temperature for 24 hours, wherein the ratio of chitosan, carboxy polyethylene glycol monomethyl ether, NHS, EDC · HCl is 1 ratio of 1 : 1: 2: 2; After the reaction is completed, the hydroxylamine is added to the amount of hydroxylamine having a substance of carboxyl polyethylene glycol monomethyl ether and then transferred to a dialysis bag with the reaction solutio...

Synthetic example 2

[0047] Synthesis azide-based PEG chitosan

[0048] It is weighed with a chitosan of 0.16 g of a molecular weight of 5 × 10 × 10 × 10 × 4 DA, and the dethritis is 98% is added to 10 ml MeS buffer (25 mM, pH = 4.80), and stirred with 0.1 ml of HCl at room temperature for half an hour, so that the shell The glycan is completely dissolved, thereby obtaining a uniform solution having a mass volume percent concentration of 1.6%; then a carboxy-polyethylene glycol-azide group, NHS-polyethylene glycol-azide group, NHS and EDC · HCl, which activates 1 hour at room temperature 1 hour, NHS and EDC · HCl mixed solution (MES cushioning solution having a solvent of 25 mM pH = 4.80) 20 mL was added to the above-mentioned reaction solution, and the reaction was continuously stirred at room temperature for 24 hours, including chitosan, carboxy-polyethylene glycol-azide, NHS, EDC · HCl The ratio of the substance is 1: 2: 4: 4; the reaction is added to the end of the amount of hydrochloride hydroxyl...

Embodiment 1

[0051] Experiments were prepared by red blood cell suspension: Take 1 volume rabbit whole blood in 50 ml of centrifuge tube, add 4 volume Tris buffer (10 mm Tris, 150 mM NaCl, pH = 7.2), 1000 × g from centrifugation for 10 minutes, and be careful Decorate, and add 5 volume Tris buffer in the lower red blood cell precipitation, and 1000 × g was centrifuged again for 10 minutes. Washed to colorlessness to be washed with the supernatant, dilute the resulting red blood cell precipitate to 5% (v / v) to 5% (v / v) to obtain a red blood cell suspension.

[0052] Soluble chitosan aqueous solution of soluble chitosan: Samples of PEG chitosan in Synthesis Example 2 were dissolved and diluted with the above Tris buffer, and the concentration of 20 mg / ml, 30 mg / ml, 40 mg / ml and 50 mg / ml sample, respectively. Solution. To 0.5 ml of 5% (v / v) red blood cell suspension, the equivalent sample solution, the like Tris buffer is a negative control, and the like 0.1% Triton X-100 (Tris buff...

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Abstract

The invention discloses a medical dressing capable of resisting bacteria and promoting wound healing. PEGylated chitosan is used as a main raw material. Wherein the PEGylated chitosan has good antibacterial property, water solubility, biological safety and biocompatibility, meanwhile, the PEGylated chitosan can induce macrophages to be polarized into an M2 phenotype with an anti-inflammatory repairing effect, generation of tissues such as blood vessels and granulation at a wound is promoted, and wound healing is promoted. Therefore, the medical dressing disclosed by the invention has the effects of resisting bacteria and promoting wound healing at the same time, and has wide application potential.

Description

Technical field [0001] The present invention relates to the technical field of medical materials. More specifically, there is a medical dressing having antibacterial and promoting wound healing. Background technique [0002] The skin is the largest organ of the human body, once the skin's integrity is destroyed, the human body will lose the first natural barrier that protects the pathogenic microbial invasion. Including skin trauma, including burning, chronic ulcers, surgical wounds, etc., etc. Make the original therapeutic demand, the length of recovery period is long, and the treatment cost is highly prolonged. It will also cause systemic sepsis and eventually lead to tissue necrosis and even amputation. Therefore, wound treatment is a major need of the country. The shortened wound healing is a gold standard for global consistency in the treatment. [0003] Chitosan is the only basic natural polysaccharide with positively charged in nature, with good antibacterial, biocompatibi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L26/00
CPCA61L26/0023A61L26/0066A61L26/009A61L2300/236A61L2300/41A61L2300/412C08L5/08Y02A50/30
Inventor 朱萌牛忠伟吴曼
Owner TECHNICAL INST OF PHYSICS & CHEMISTRY - CHINESE ACAD OF SCI
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