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Mesoporous silicon loaded with hyaluronic acid and resveratrol as well as preparation method and application thereof

A technology of resveratrol and hyaluronic acid, applied in the field of biomedical engineering, can solve problems such as poor spreadability, poor adhesion, and limited application, and achieve enhanced moisturizing and anti-oxidation effects and biocompatibility Reinforcement, good thermal stability

Pending Publication Date: 2022-04-01
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It is a good way to improve the solubility of resveratrol by preparing resveratrol into resveratrol nanoemulsion. Although microemulsion has many advantages, it is difficult to apply on the skin due to poor adhesion and poor spreadability. Defects such as long-term residence limit its application

Method used

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  • Mesoporous silicon loaded with hyaluronic acid and resveratrol as well as preparation method and application thereof
  • Mesoporous silicon loaded with hyaluronic acid and resveratrol as well as preparation method and application thereof
  • Mesoporous silicon loaded with hyaluronic acid and resveratrol as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] (1) The preparation method of mesoporous silicon: mix 1mL of cetyltrimethylammonium chloride (CTAC) aqueous solution (the concentration of CTAC aqueous solution is 25wt%, 0.756mol / L) with 120mL of water, 0.876mL of 2M NaOH Stir the aqueous solution at 80°C for 1 hour, then add 1 mL of tetraethyl orthosilicate (98% TEOS solution, 4.388 mol / L), react for 2 hours, then centrifuge, wash twice with ethanol, wash twice with water, and place in vacuum Dry in a drying oven, transfer to a muffle furnace after drying, and dry at 600°C for 5 hours to obtain mesoporous silicon;

[0037] (2) Amination modification of mesoporous silicon: add 0.2 g of mesoporous silicon to 20 mL of isopropanol and sonicate for 20 minutes, replenish isopropanol to 100 mL, add 2 mL of 3-aminopropyltriethoxysilane (4.2 mol / L) , stirred at 80°C for 24 hours, centrifuged, washed several times with isopropanol, and freeze-dried to obtain aminated mesoporous silicon;

[0038] (3) Hyaluronic acid modificatio...

Embodiment 2

[0043] Stir 1 mL of cetyltrimethylammonium chloride (CTAC) aqueous solution (concentration of CTAC aqueous solution is 25 wt%, 0.756 mol / L) with 120 mL of water and 0.784 mL of 2.5 M NaOH aqueous solution at 85° C. for 0.5 h, Then add 1.14mL of tetraethyl orthosilicate (98% TEOS solution, 4.388mol / L), react for 1.5 hours, then centrifuge, wash with ethanol twice, wash twice with water, then place in a vacuum oven to dry until the drying is complete Then transfer to a muffle furnace and dry at 550°C for 5 hours to obtain mesoporous silicon.

[0044] (2) Amination modification of mesoporous silicon: Add 0.37 g of mesoporous silicon to 25 mL of isopropanol and sonicate for 30 minutes, replenish isopropanol to 275 mL, add 2 mL of 3-aminopropyltriethoxysilane (4.2 mol / L ), stirred at 75° C. for 28 h, centrifuged, washed several times with isopropanol, and freeze-dried to obtain aminated mesoporous silicon.

[0045] (3) Hyaluronic acid modification of mesoporous silicon: add 0.12 g...

Embodiment 3

[0049] Stir 1mL of cetyltrimethylammonium chloride (CTAC) aqueous solution (the concentration of CTAC aqueous solution is 25wt%, 0.756mol / L) with 120mL of water and 1mL of 1.5M ammonia water at 75°C for 1.5h, then add 0.85mL tetraethyl orthosilicate (98% TEOS solution, 4.388mol / L), reacted for 2.5 hours, centrifuged, washed twice with ethanol, washed twice with water, then dried in a vacuum oven, transferred after drying Dry in a muffle furnace at 575°C for 5 hours to obtain mesoporous silicon.

[0050] (2) Amination modification of mesoporous silicon: Add 0.136g of mesoporous silicon to 27mL isopropanol and sonicate for 10min, replenish isopropanol to 95mL, add 2mL 3-aminopropyltriethoxysilane (4.2mol / L ), stirred at 77.5° C. for 20 h, centrifuged, washed several times with isopropanol, and freeze-dried to obtain aminated mesoporous silicon.

[0051] (3) Hyaluronic acid modification of mesoporous silicon: add 0.12 g of sodium hyaluronate into a Tris-HCl buffer solution with ...

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Abstract

The invention discloses hyaluronic acid and resveratrol loaded mesoporous silicon as well as a preparation method and application thereof, and belongs to the field of biomedical engineering. The preparation method comprises the following steps: firstly, preparing mesoporous silicon by adopting a sol-gel method, then carrying out surface amino modification by using a silane conjugate, and then forming an amido bond to be connected with hyaluronic acid. The drug loading system prepared by the method can increase the water solubility and bioavailability of resveratrol, so that the capability of removing active oxygen generated by ultraviolet radiation is further enhanced. Meanwhile, due to the fact that the hyaluronic acid is contained, the excellent moisturizing and anti-oxidation effects are achieved.

Description

technical field [0001] The invention belongs to the field of biomedical engineering, and specifically relates to mesoporous silicon loaded with hyaluronic acid and resveratrol, a preparation method and application thereof. Background technique [0002] Mesoporous silicon (MSNs) mostly refers to amorphous silica materials with a pore size of 2-50 nm. Different synthesis methods, rich silanol-based surfaces and excellent mesoporous structures make MSNs have adjustable particle size, functional Simple, large specific surface area, large pore volume, uniform pore diameter and so on. These properties make MSNs excellent carriers for drug delivery applications. Resveratrol (Resveratrol, referred to as RES), also known as stilbenzol, belongs to natural polyphenolic compounds, and is a phytoalexin produced by plants in response to bacterial or fungal invasion, ultraviolet radiation, trauma and stress. Studies have found it to be an active ingredient in certain herbal remedies for ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/69A61K47/61A61K31/05A61K31/728A61P17/00A61P39/06A61P17/18
Inventor 魏坤郑芳刘媛琪
Owner SOUTH CHINA UNIV OF TECH
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