Polyacrylic resin modified adsorption drug carrier and preparation method thereof

Abstract

The invention provides a polyacrylic resin modified adsorption drug carrier and a preparation method thereof, and relates to the technical field of carrier processing. The polyacrylic resin modified adsorption drug carrier is prepared by carrying out modification treatment on polyacrylic resin IV, chitosan, quaternary ammonium salt, modified carbon nanotubes, sucrose acetate isobutyrate, allyl pentaerythritol ether, hydroxyapatite, a cross-linking agent, an initiator, polyvinyl alcohol, polyethylene glycol, a thickening agent and the like by using the polyacrylic resin IV, and then adding the chitosan, the quaternary ammonium salt, the modified carbon nanotubes, the sucrose acetate isobutyrate, the allyl pentaerythritol ether, the hydroxyapatite, the cross-linking agent, the initiator, the polyvinyl alcohol, the polyethylene glycol, the thickening agent and the like. The preparation method comprises the following steps: preparation of a modified polyacrylic resin IV suspension, material mixing, mixed spinning and heating combination. The defects in the prior art are overcome, the medicine can be effectively and uniformly slowly released after being adsorbed and entering the stomach of the human body, the long-term effect of treatment components is achieved, the hygroscopicity of the medicine is reduced, the storage time of the medicine is guaranteed, abuse of the medicine is prevented, and the safety is improved.

Description

technical field [0001] The invention relates to the technical field of drug carrier processing, in particular to a polyacrylic acid resin modified adsorption drug carrier and a preparation method thereof. Background technique [0002] With the vigorous development of medicine, people have more and more quality means to face diseases. They can cure diseases by developing different drugs. If it cannot be controlled, it will cause high drug concentration in a short period of time, resulting in drug toxicity and side effects, making the drug utilization rate low. In order to achieve a safe and effective therapeutic effect, it usually requires multiple small doses of drug administration. This method of drug administration is generally suitable for patients with severe emergencies. , but in order to achieve long-term pain relief, the general patient needs the drug to act slowly on the human body to achieve the effect of continuously fighting against physical discomfort. [0003] ...

AI Technical Summary

Problems solved by technology

However, although polyacrylic acid can achieve a good drug release slowing effect, it cannot control the slow release rate of the drug very well. It often has the same problems as other drug carriers, such as slow release speed in the early stage and slow and fast drug release in the later stage, which is easy to cause drug release. Concentrated and slow release, while polyacrylic acid has good swelling effect in water and ethanol, it is not easy to extract certain drugs such as cold medicines and painkillers to prevent drug abuse, but the crosslinking of polyacrylic acid itself The strength is not high, the crushing strength is low, the anti-abuse performance is average, and the moisture absorption capacity is strong, easy to agglomerate, difficult to store, and the high-concentration glue is irritating to the eyes, nose and throat, which causes certain troubles to the actual application.

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