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Conductive composite hydrogel coating neural electrode and preparation method and application thereof

A composite hydrogel and conductive hydrogel technology, applied in the field of nerve electrodes, can solve the problems of increasing the difficulty and cost of signal processing, increasing the signal-to-noise content, reducing the signal-to-noise ratio, etc., to improve biomechanical properties, reduce impedance, The effect of high sensitivity and signal-to-noise ratio

Pending Publication Date: 2022-04-15
SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The impedance value of the electrode has a significant impact on the quality of the extracted neural signal. An increase in impedance will significantly increase the noise content in the signal, reduce the signal-to-noise ratio, and increase the difficulty and cost of signal processing

Method used

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  • Conductive composite hydrogel coating neural electrode and preparation method and application thereof
  • Conductive composite hydrogel coating neural electrode and preparation method and application thereof
  • Conductive composite hydrogel coating neural electrode and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] In this embodiment, a conductive composite hydrogel-coated nerve electrode is prepared, and the specific process is as follows:

[0047] S1: if figure 1 As shown, first prepare the aluminum microwire electrode (diameter of aluminum microwire: 127μm), and use the constant current method to activate it (current size: 50μA ~ 500μA), the electrolyte is a mixed solution of 0.1M concentrated nitric acid and 0.1M pyrrole , the activation time is 90s. After the activation, use deionized water to clean the electrode at least three times and dry it;

[0048] S2: Polypyrrole was deposited on the surface of the activated aluminum microwire electrode by cyclic voltammetry, the electrolyte was a mixed solution of 0.1M oxalic acid and 0.5M pyrrole, the voltage range was -1.0-3.0V, and the scan rate was 25mV / s. The number of scanning circles is 10 circles. After the deposition, the electrode is cleaned with deionized water at least three times and dried for later use. The prepared ele...

Embodiment 2

[0051] In this embodiment, a conductive composite hydrogel-coated nerve electrode is prepared, and the specific process is as follows:

[0052] S1: Immerse the Ppy-Al electrode prepared in S2 in Example 1 into a solution containing 10mLV 2 o 5 2wt% SA solution of nano-sol, and slowly pulled out from the solution (about 30s), then immediately put into 2wt% SrCl 2 . 6H 2 Physically cross-link in O solution for 5 minutes and repeat the above dip coating process 5 times, dry at room temperature for later use, recorded as SA / V 2 o 5 -Al;

[0053] S2: The SA / V prepared in the above S1 2 o 5 - The Al electrode was immersed in a 0.29M pyrrole / 1M oxalic acid mixed solution for 12 hours. After the reaction, the electrode was thoroughly washed with deionized water to remove unreacted monomers and dried to obtain a sodium alginate / polypyrrole nanofiber composite hydrogel coating. Covered Ppy-Al, denoted as SA / Ppy NF-Al.

Embodiment 3

[0055] In this example, sodium alginate / polypyrrole nanofiber composite hydrogels with different polypyrrole nanofiber contents were prepared. The specific process is as follows:

[0056] S1: Different volumes (0mL, 1mL, 5mL, 10mL and 20mL) of V 2 o 5 The nano-sol was uniformly mixed with 50mL of 2wt% sodium alginate solution, and 2wt% of SrCl 2 . 6H 2 O solution is physically cross-linked to form a composite hydrogel;

[0057] S2: Soak the composite hydrogel prepared in S1 in a mixed solution of 0.29M pyrrole / 1M oxalic acid. After reacting for 12 hours, wash the composite hydrogel thoroughly with deionized water to remove unreacted monomers, and finally obtain sodium alginate / polypyrrole nanofiber composite hydrogels, respectively denoted as SA / Ppy, SA / Ppy NF-1, SA / Ppy NF-5, SA / Ppy NF-10 and SA / PpyNF-20.

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Abstract

The invention provides a conductive composite hydrogel coating neural electrode as well as a preparation method and application thereof. The hydrogel coating in the neural electrode can be used as an effective mechanical buffer layer of the neural electrode and can also improve the biocompatibility of the neural electrode on a neural interface; meanwhile, the hydrogel coating can be subjected to functionalization treatment to expand the performance of the neural electrode. The conductive polymer layer is deposited on the conductive substrate in an electro-deposition mode, the thickness and the surface appearance of the conductive polymer layer can be easily controlled, and the conductive hydrogel coated with the dip-coating impregnation method does not have chemical reaction with the conductive substrate.

Description

technical field [0001] The invention belongs to the technical field of nerve electrodes, in particular to a conductive composite hydrogel-coated nerve electrode and its preparation method and application. Background technique [0002] As one of the core organs of the human body, the brain is responsible for regulating various physiological activities of the body. Due to the precision and complexity of the brain's nervous system, our understanding of it is still in its infancy. Implantable nerve electrodes serve as an intermediary between external devices and neural tissue, and can be used to record nerve signals and deliver electrical stimulation. Implantable nerve electrodes stimulate nerve tissue and activate neuron activity to treat neurodegenerative-related diseases and dysfunctional diseases caused by neurological defects, such as Alzheimer's disease, epilepsy, motor nerve disorders, hearing loss, etc. [0003] Due to the mismatch of mechanical properties between hard...

Claims

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Application Information

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IPC IPC(8): C09D5/24C09D5/08C09D165/00C09D179/02C09D105/04C09D7/61A61N1/05A61B5/266A61B5/294
Inventor 刘杨殷鹏飞肖林张超
Owner SUN YAT SEN UNIV
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