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Preparation and application of photo-response nitric oxide delivery/photo-thermal synergistic material

A nitric oxide, photothermal synergistic technology, applied in medical preparations with non-active ingredients, wave energy or particle radiation treatment materials, medical preparations containing active ingredients, etc., can solve the problems of biological damage and achieve improved Stability, excellent photothermal effect, and synergistic therapeutic effects

Pending Publication Date: 2022-04-22
UNIV OF SCI & TECH OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Among them, the purpose of controlled release can be achieved by triggering the release of nitric oxide by light. The compounds that release nitric oxide in response to light mainly include derivatives of nitrobenzene and N-nitrosamine derivatives. However, derivatives of nitrobenzene The triggering of objects requires a greater intensity of light, and high-intensity radiation will cause greater damage to organisms

Method used

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  • Preparation and application of photo-response nitric oxide delivery/photo-thermal synergistic material
  • Preparation and application of photo-response nitric oxide delivery/photo-thermal synergistic material
  • Preparation and application of photo-response nitric oxide delivery/photo-thermal synergistic material

Examples

Experimental program
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Effect test

Embodiment 1

[0047] In the first step, the nitric oxide releasing unit is prepared, the Schiff base is generated by the reaction of the aldehyde group and the amino group, then the Schiff base is reduced, and finally the nitric oxide releasing unit is obtained through the nitrosation reaction. The synthesis process is simple and easy to operate. In order to help understand more clearly, one of the structural compounds of formula I is mainly selected as an example below, and the specific reaction formula is as follows:

[0048]

[0049] Nitric oxide donor preparation method:

[0050] A (250mg, 0.381mmol, 1eq) and o-nitrobenzaldehyde (1.174g, 7.722mmol, 20eq) were added into a mixed solvent of absolute ethanol and anhydrous THF (1:1, 30mL), and refluxed at 90°C. After reacting for 24 hours, the solvent was removed by rotary evaporation, and ethanol was added for ultrasonic washing, suction filtered, washed with ethanol and dried to obtain 220 mg of dark blue powder B (71.8%).

[0051] B...

Embodiment 2

[0058] Example 2: White light triggers the release of nitric oxide and 808nm laser light to produce photothermal effect

[0059] Determination of NP-1, NP-2 nitric oxide release by UV-Vis absorption spectroscopy: using white LED light (62.6mW / cm 2 ) According to the nanoparticle assembly NP-1 or NP-2 obtained above, track the change of its ultraviolet-visible light absorption spectrum. The test results show that: with the prolongation of the illumination time, the absorption peak of polymer nanoparticles at 711nm decreases rapidly, and the corresponding new absorption peak at 780nm increases rapidly, and finally tends to balance, indicating that the polymer nanoparticles have photoresponsiveness. And after adding the Giress reagent, the color of the solution turns purple, indicating that nitric oxide is released, and the apparent color of the polymer nanoparticles changes from the initial blue to purple when illuminated. Figure 9 Shown are the ultraviolet-visible light absor...

Embodiment 3

[0061] Example 3: Fluorescence changes of NP-1 and NP-2 before and after white light illumination

[0062] Using white LED (62.6mW / cm 2 ) light illuminates the nanoparticle assembly obtained above, and performs a fluorescence emission spectrum test after 12 minutes of illumination. The test results show that: with the prolongation of the illumination time, the fluorescence at 825nm in the fluorescence emission spectrum increases, and the fluorescence at 760nm becomes weaker (excitation wavelength is 633nm), so it can indirectly reflect the release of nitric oxide. The test results are shown in Figure 11 .

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Abstract

The invention discloses preparation and application of a photo-response nitric oxide delivery / photo-thermal synergistic material, and firstly relates to a multifunctional nitric oxide donor molecule which has a structure shown as a formula I. The nitric oxide donor molecule provided by the invention and an amphiphilic polymer are jointly dissolved in an organic solvent; stable nano particles, namely the polymer assembly, are obtained through co-assembly in a nano flash precipitation mode, nitric oxide can be controllably released under white light irradiation, the stability of nitric oxide is improved, meanwhile, an efficient photo-thermal effect is achieved under 808 nm laser, and collaborative treatment is achieved.

Description

technical field [0001] The invention belongs to the technical field of nitric oxide donor compounds, and in particular relates to the preparation and application of a light-responsive nitric oxide delivery / photothermal synergistic material. Background technique [0002] The overuse of antibiotics has led to resistance in many pathogens. In recent decades, multidrug-resistant bacteria have become a more common cause of refractory infections. The drug resistance of multidrug-resistant bacteria is caused by the structural transformation or gene mutation of planktonic bacteria on the one hand; on the other hand, it includes the protection of biofilms, and bacterial cells are wrapped in exopolysaccharides, proteins, enzymes and extracellular bacterial DNA. Self-made extracellular polymer substance (EPS). EPS acts as a protective barrier against antibiotic penetration and cellular attack by host innate immune cells. [0003] In order to solve drug-resistant bacterial infections...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/69A61K41/00A61K47/34A61K9/51A61P31/04
CPCA61K31/69A61K41/0052A61K47/34A61K9/5146A61P31/04Y02A50/30
Inventor 胡进明包鑫垚
Owner UNIV OF SCI & TECH OF CHINA
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