A kind of hydrogel with ph/glucose dual response release metformin and its preparation method and application

A metformin-responsive technology, applied in pharmaceutical formulations, bandages, drug delivery, etc., can solve problems such as insufficient adhesion, low electrical conductivity, and difficulty in angiogenesis, and achieve the effects of promoting wound healing, promoting blood circulation, and repairing blood vessels

Active Publication Date: 2022-06-24
XI AN JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In order to solve the problems in the prior art, the gel dressing for diabetic wounds has insufficient adhesion performance, low oxidation resistance, difficult angiogenesis at the wound and low electrical conductivity.

Method used

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  • A kind of hydrogel with ph/glucose dual response release metformin and its preparation method and application
  • A kind of hydrogel with ph/glucose dual response release metformin and its preparation method and application
  • A kind of hydrogel with ph/glucose dual response release metformin and its preparation method and application

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preparation example Construction

[0048] The invention discloses a preparation method of a hydrogel with pH / glucose dual-responsive metformin release, which specifically includes the following steps:

[0049] Step 1: Under the action of 1-(3-dimethylpropyl)-3-ethylcarbodiimide hydrochloride (EDC), dihydrocaffeic acid is grafted onto the chitosan backbone to form a shell Glycan grafted dihydrocaffeic acid (CS-DA);

[0050] The specific preparation steps of chitosan grafting dihydrocaffeic acid include:

[0051] (1A) Dissolve 0.523 g of chitosan in 45 mL of deionized water, stir at room temperature to fully dissolve;

[0052] (1B) adding 1M hydrochloric acid to the solution obtained in (1A) to adjust the pH of the solution to about 5.0 to form a chitosan solution;

[0053] (1C) Add 0.30-1.2 g of dihydrocaffeic acid to the chitosan solution obtained in (1B) above to form mixed solution A; quickly add 0.62-2.48 g of 1-(3-dimethylamino) into mixed solution A propyl)-3-ethylcarbodiimide hydrochloride (EDC), stir ...

Embodiment 1

[0083] (1) Under the action of 1-(3-dimethylpropyl)-3-ethylcarbodiimide hydrochloride (EDC), dihydrocaffeic acid was grafted to the main chain of chitosan to form chitosan Sugar-grafted dihydrocaffeic acid (CS-DA):

[0084] (1A) Dissolve 0.523 g of chitosan in 45 mL of deionized water, stir at room temperature to fully dissolve;

[0085] (1B) adding 1M hydrochloric acid to the solution obtained in (1A) to adjust the pH of the solution to about 5.0;

[0086] (1C) 0.591g of dihydrocaffeic acid was added to the solution obtained in the above (1B), and 1.239g of EDC was added rapidly, and the solution was mixed well with full stirring;

[0087] (1D) adding 1M hydrochloric acid to the solution obtained in (1C) to adjust the pH of the solution between 5.0 and 6.0, and stirring for 8 hours;

[0088] (1E) The pH=5 of the dialysis water was adjusted with 1M hydrochloric acid, and the solution obtained in (1D) was dialyzed therein for 72 hours.

[0089] (2A) 0.565g L-arginine was dis...

Embodiment 2

[0106] Different from Example 1, the 1.5 wt % CDL solution in step (5) was replaced with 2.25 wt %, and the prepared hydrogel was named PC2.

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Abstract

The present invention relates to a hydrogel with pH / glucose double-responsive metformin release and its preparation method and application. In the preparation method, polydopamine-coated reduced graphene oxide (rGO@PDA) and metformin (Met) are simultaneously added to Benzaldehyde and phenylboronic acid double-modified polyethylene glycol copoly(glycerol sebacate) (PPB) solution followed by chitosan (CDL) solution co-grafted with dihydrocaffeic acid and L-arginine Mixed, cross-linked by Schiff base and phenyl boronate to form PC / GO / Met hydrogel with pH / glucose dual responsiveness. The method has wide sources of raw materials, simple preparation process, and low preparation cost. The prepared hydrogel dressing has dual responsiveness, can release drugs that are helpful for type II diabetic wound healing, promote diabetic wound healing, and has pH / glucose dual responsiveness. It also has good adhesion, antibacterial, anti-oxidation, blood coagulation and hemostatic ability in vivo.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and in particular relates to a hydrogel capable of releasing metformin with a dual pH / glucose response and a preparation method and application thereof. Background technique [0002] Diabetes is one of the chronic diseases with the highest incidence in the world. Patients with diabetes often have vascular lesions around the lower limbs, resulting in insufficient blood supply to the foot wounds, which is also the main reason for the difficulty in healing wounds in the diabetic area. Statistics show that of the 3 million people hospitalized with diabetes in the United States, about 20% are due to foot ulcers and their complications. In addition, hyperglycemia, chronic inflammation, poor angiogenesis, and granulation tissue formation are also common problems in diabetic wounds. These factors cause diabetic wounds to take longer to heal than normal, leading to chronic wounds and possibl...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L26/00
CPCA61L26/008A61L26/0066A61L26/0061A61L26/0023A61L26/0019A61L26/0004A61L2300/412A61L2300/404A61L2300/418A61L2400/04C08L5/08C08L79/02C08L71/02
Inventor 郭保林乔博雯梁永平
Owner XI AN JIAOTONG UNIV
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