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Preparation process of biological ceramic-degradable polymer composite granules

A technology of bioceramics and preparation technology, which is applied in the field of preparation technology of bioceramics-degradable polymer composite granulation, which can solve the problems of poor mechanical strength, not tissue repair and regeneration materials, and high brittleness, so as to improve the mixing uniformity , excellent mechanical properties, full particle size effect

Pending Publication Date: 2022-05-13
JIANGXI UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Bioceramics has good biocompatibility, bioactivity and tissue conductivity due to its composition and structure similar to the inorganic components of human hard tissues, but there are problems such as poor toughness, high brittleness, and slow degradation rate; biodegradable high Molecular materials have good biocompatibility, biodegradability, non-toxicity, and good mechanical compatibility and formability. They are the most widely used scaffold materials in tissue regeneration and repair, but the disadvantage is that their mechanical strength is poor. , not biologically active and tissue conductive
Therefore, a single bioceramic or biodegradable polymer material is not an ideal tissue repair and regeneration material

Method used

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  • Preparation process of biological ceramic-degradable polymer composite granules
  • Preparation process of biological ceramic-degradable polymer composite granules
  • Preparation process of biological ceramic-degradable polymer composite granules

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Weigh 0.1kg of bioceramic HA powder with a particle size of 10um and 0.9kg of biodegradable polymer material PLA powder with a particle size of 20um according to the mass ratio distribution of 1:9, add the two to the ball mill jar and add large, medium and The mass ratio of small grinding balls is 1:1:1 (the ratio of ball to material is 1:1). First rotate clockwise at 100rad / min, ball milling time is 10min, stop for 1min; then turn counterclockwise, speed is 100rad / min, ball milling time is 10min, stop for 1min; reciprocate; ball milling time is 3h, and bioceramic-can be obtained Degradable polymer mixed powder. Using the above composite powder as raw material, set the temperature of the first to sixth zones of the barrel of the twin-screw extruder, the temperature of the first zone is 170°C, the temperature of the second zone is 175°C, the temperature of the third zone is 170°C, The temperature in the fourth zone is 160°C, the temperature in the fifth zone is 180°C, a...

Embodiment 2

[0053] Weigh 0.2kg of bioceramic HA powder with a particle size of 10um and 0.8kg of biodegradable polymer material PLA powder with a particle size of 20um according to the mass ratio distribution of 1:4, add both to the ball mill jar and add large, medium, and The mass ratio of small grinding balls is 1:3:5 (the ratio of ball to material is 1:1). First rotate clockwise at 100rad / min, ball milling time is 10min, stop for 1min; then turn counterclockwise, speed is 100rad / min, ball milling time is 10min, stop for 1min; reciprocate; ball milling time is 3h, and bioceramic-can be obtained Degradable polymer mixed powder. Using the above composite powder as raw material, set the temperature of the first to sixth zones of the barrel of the twin-screw extruder, the temperature of the first zone is 170°C, the temperature of the second zone is 175°C, the temperature of the third zone is 170°C, The temperature in the fourth zone is 160°C, the temperature in the fifth zone is 180°C, and...

Embodiment 3

[0059] Weigh 0.2kg of bioceramic HA powder with a particle size of 10um and 0.8kg of biodegradable polymer material PLA powder with a particle size of 20um according to the mass ratio distribution of 1:4, add both to the ball mill jar and add large, medium, and The mass ratio of small grinding balls is 1:3:5 (the ratio of ball to material is 1:1). First clockwise rotation speed is 200rad / min, ball milling time is 20min, stop for 2min; then rotate counterclockwise, rotation speed is 200rad / min, ball milling time is 20min, stop for 2min; cycle reciprocating; ball milling time is 4h to obtain bioceramic Degradable polymer mixed powder. Using the above composite powder as raw material, set the temperature of the first to sixth zones of the barrel of the twin-screw extruder, the temperature of the first zone is 170°C, the temperature of the second zone is 175°C, the temperature of the third zone is 170°C, The temperature in the fourth zone is 160°C, the temperature in the fifth zo...

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Abstract

The invention discloses a preparation process of biological ceramic-degradable polymer composite granules, which comprises the following steps: mixing biological ceramic powder and degradable polymer material powder in proportion, putting the mixture into a ball mill, carrying out mechanical ball milling by using large, medium and small milling balls to obtain composite powder, and putting the composite powder into a vacuum system for vacuum drying; and putting the composite powder into an extruder, starting a water-cooling brace pelletizing system, a water circulation system, a blow-drying machine and a pelletizing machine, and carrying out extrusion machine foundation, cooling molding and cutting pelletizing on the material to obtain the biological ceramic-degradable polymer composite material. According to the preparation method, the advantages of mechanical ball milling and extrusion granulation processes are combined, and the ceramic and the macromolecules are uniformly mixed by utilizing the strong impact force, shearing force and grinding force of the mechanical ball milling process; the excellent melting, extruding and mixing capacities of the extruding and granulating process are utilized to plasticize, wrap and granulate ceramics and macromolecules, and the composite material meeting the requirements of regenerated tissues and organs is prepared.

Description

technical field [0001] The invention belongs to the technical field of biological material preparation, and more specifically, the invention relates to a preparation process of bioceramic-degradable polymer composite granulation. Background technique [0002] Bioceramics has good biocompatibility, bioactivity and tissue conductivity due to its composition and structure similar to the inorganic components of human hard tissues, but there are problems such as poor toughness, high brittleness, and slow degradation rate; biodegradable high Molecular materials have good biocompatibility, biodegradability, non-toxicity, and good mechanical compatibility and formability. They are the most widely used scaffold materials in tissue regeneration and repair, but the disadvantage is that their mechanical strength is poor. , No biological activity and tissue conductivity. Therefore, a single bioceramic or biodegradable polymer material is not an ideal tissue repair and regeneration mater...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B29B13/10B29B9/06C08J3/12C08L67/04C08L69/00C08L33/26C08L91/06C08K3/04C08K5/17C08K3/32
CPCB29B13/10B29B9/06C08J3/12C08J2367/04C08J2469/00C08J2433/26C08J2491/06C08K3/04C08K5/175C08K2003/325
Inventor 帅词俊戚方伟
Owner JIANGXI UNIV OF SCI & TECH
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