Prothioconazole and chlorothalonil compound water dispersible granule and preparation method thereof

A technology of prothioconazole and chlorothalonil, which is applied in the field of prothioconazole and chlorothalonil compounded water-dispersible granules and its preparation, can solve the problems of high decomposition rate of prothioconazole original drug, achieve good dispersion, The core-shell structure is uniform and the effect of avoiding decomposition

Active Publication Date: 2022-06-07
NANJING FORESTRY UNIV +1
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] Aiming at the problem of high decomposition rate of prothioconazole original drug in the prothioconazole and chlorothalonil compounded water-dispersible granule preparation in the prior art, the present invention provides a kind of prothioconazole and chlorothalonil compounded water-dispersible granule and a preparation method thereof. A core-shell structure is prepared by depositing a layer of high molecular polymer on the surface of prothioconazole particles. The high molecular polymer is prepared by using a macromolecular chain transfer agent macromonomer and a crosslinking agent to effectively reduce the concentration of propylsulfide. Decomposition rate of prothioconazole in water dispersible granules formulated with cloconazole and chlorothalonil

Method used

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  • Prothioconazole and chlorothalonil compound water dispersible granule and preparation method thereof
  • Prothioconazole and chlorothalonil compound water dispersible granule and preparation method thereof
  • Prothioconazole and chlorothalonil compound water dispersible granule and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0078] Step 1: 42.5% Bacillus clear suspension preparation

[0079]

[0080] The above components are put into the mixing kettle in turn, stirred evenly, through the sand mill wet sand grinding, sand grinding medium using 1.6-2.8 mm zirconia material, grinding temperature control below 50 °C, the material liquid grinding to 90% particle size (D90) less than 5 μm, to obtain a bacterium clear suspension B1.

[0081] Step 2: Prophiamazole suspension precursor preparation

[0082]

[0083] The above components are put into the mixing kettle in turn, stirred evenly, by the sand mill wet sand grinding, sand grinding medium using 1.6-2.8 mm zirconia material, grinding temperature control below 50 °C, the material liquid grinding to D90 (90% particle size) less than 5 μm, to obtain propylthiazole suspension precursor.

[0084] Step 3: Preparation of 21.25% nuclear-shell structure propioniazole suspension

[0085]Step 3-1: Preparation of the core-shell structure prophiapazole: the acti...

Embodiment 2- Embodiment 7 and comparative example 2-7

[0096] Step 1: 42.5% Bacillus clear suspension preparation, with Example 1.

[0097] Step 2: Propethiazole suspension precursor preparation, basically the same as Example 1, the difference is that the amount of water added to ensure the core shell structure propylthiazole nuclear shell suspension total raw materials (including propionhiazole original drug, SP-DF2238, SP-DF2292, SP-DF2209, water, active chain transfer agent for the formation of the core shell structure of the large monomer, crosslinking agent, initiator and filler) added to the amount of 100 parts. Among them, the polyacrylic acid- polystyrene - RAFT reagent (PAA) used in a logarithmic ratio 27 -PSt 5 -RAFT), prepared by the preparation method in the master's thesis of Zhejiang University "Raft Emulsion Polymerization Mechanism and Preparation of Poly (Styrene-Butyl Acrylate-Styrene)".

[0098] Step 3: Preparation of 21.25% core-shell structure propioniziazole suspension:

[0099] Step 3-1: Step 1, with Example 1, ...

Embodiment 8

[0112] Preparation stability studies

[0113] The stability test of the preparation was carried out by liquid chromatography to detect the effective content of the original chinese medicine of the preparation, and the conditions for determination by high performance liquid chromatography were: mobile phase: acetonitrile: aqueous solution of ammonium carbonate (0.01mol / L) = 45:55; wavelength: 220 nm; Flow rate: 1.0ml / min.

[0114] Prophiamazole (non-core shell structure) prepared in proportion 1 + bacterium clear water dispersible granules and Example 1-7 and prophimethiazole (nuclear shell structure) prepared in proportion 2-7 + bacterium clear water dispersible granules under the above conditions the decomposition rate is shown in Table 5.

[0115] Table 5 contrasts the proportion of 1-7 and Example 1-7 water dispersible granules in prophiazole active content decomposition rate

[0116] sample Decomposition rate Contrast ratio 1 (non-core shell structure) 65％ E...

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Abstract

The invention discloses prothioconazole and chlorothalonil compound water dispersible granules and a preparation method thereof, and belongs to the field of pesticide preparations. The prothioconazole and chlorothalonil compound water dispersible granule comprises chlorothalonil raw medicine, core-shell structure prothioconazole, a dispersing agent, a wetting agent, citric acid and filler, and the core-shell structure prothioconazole is prepared by the following steps: adding an active chain transfer agent macromonomer into a prothioconazole suspension while stirring, adding an initiator, heating, dropwise adding a cross-linking agent, stirring, and cooling to obtain the prothioconazole and chlorothalonil compound water dispersible granule. A polymer formed by the active chain transfer agent macromonomer and the cross-linking agent is uniformly deposited on the surfaces of prothioconazole particles. The active chain transfer agent macromonomer is cross-linked by the cross-linking agent to form a polymer with a network structure to wrap the surfaces of the prothioconazole particles, so that the prothioconazole is effectively prevented from being decomposed (the decomposition rate is less than or equal to 5%), and the commercialization of the prothioconazole and chlorothalonil compound water dispersible granules becomes possible.

Description

[0001] Priority Statement [0002] This application claims priority of application number CN202111211384.8 filed on October 18, 2021 and is introduced by reference in its entirety. Technical field [0003] The present invention belongs to the field of pesticide formulations, more particularly, relates to a kind of propionazole and bacteriocinus clear compound water dispersible granules thereof and preparation method thereof. Background [0004] Prophiazole is mainly used to control many diseases such as wheat, barley, rapeseed, peanuts, rice and legumes. Almost all wheat diseases have a good control effect, such as wheat and barley powdery mildew, blight, blight, leaf spot disease, rust, sclerotia, reticulosis, cloud disease and so on. It can also control soil-borne diseases of oil and peanuts, such as sclerotia, as well as major foliar diseases such as gray mold, black spot disease, brown spot disease, black shin disease, sclerotia and rust. The mechanism of action is to inhibit ...

Claims

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Application Information

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IPC IPC(8): A01N25/14A01N25/26A01N43/653A01N37/34A01P3/00
CPCA01N25/14A01N25/26A01N43/653A01N37/34
Inventor 秦宇丁秀丽顾晓利杜国涛
Owner NANJING FORESTRY UNIV
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