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Microemulsion composition of oleanolic acid as well as preparation method and application of microemulsion composition

The technology of oleanolic acid and composition is applied in the fields of oleanolic acid micro-emulsion composition and preparation of cosmetics and external skin preparations, which can solve the problems of easy degradation and instability, achieve good light transmittance, slow down volatilization and the like. , good sensory effect

Pending Publication Date: 2022-07-29
泉州达浔生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0017] The second of the technical problem to be solved in the present invention is to provide a kind of microemulsion or nanoemulsion composition and nano lipid carrier composition based on the above-mentioned microemulsion composition, and the composition can improve the concentration of oleanolic acid and plant essential oil in water. At the same time of solubility and transdermal absorption capacity, it overcomes the shortcomings of plant essential oils that are unstable, easily degraded (by oxidation, volatilization, heating and light), and insoluble in water: oleanolic acid enhances the stability of plant essential oils, and also contains cyclodextrin And the water phase of water-soluble chitosan derivatives is loaded with plant essential oils and oleanolic acid in the form of oil-in-water microemulsion or nano-lipid carrier, preventing the contact of plant essential oils with air, and the slow release and stability are further improved

Method used

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  • Microemulsion composition of oleanolic acid as well as preparation method and application of microemulsion composition
  • Microemulsion composition of oleanolic acid as well as preparation method and application of microemulsion composition
  • Microemulsion composition of oleanolic acid as well as preparation method and application of microemulsion composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0118] A kind of oleanolic acid microemulsion, including each raw material component of following weight percent, as shown in table 1:

[0119] Table 1

[0120]

[0121]

[0122] Preparation:

[0123] S1-1. take by weighing dipropylene glycol, ethanol, glycerol polyether-26, rosemary essential oil, cedarwood essential oil and octyl glucoside, polyoxyethylene 35 castor oil, mix and stir in container A, then add the amount of Oleanolic acid is stirred until completely dissolved to obtain a lipophilic phase;

[0124] S1-2. Weigh hydroxypropyl-β-cyclodextrin, add in the water in container B to dissolve, then add carboxymethyl chitosan and stir to obtain water phase after fully swelling;

[0125] S1-3. The lipophilic phase is slowly added to the water phase while stirring to self-emulsify to obtain clear and transparent microemulsion colostrum;

[0126] S1-4. Lecithin was added to container B, followed by stirring with a high-speed homogenizer at 18,000 rpm for 10 minutes ...

Embodiment 2

[0127] Embodiment 2: An oleanolic acid nanostructure lipid carrier, comprising the finished product of the microemulsion prepared by each raw material component in Example 1 and each raw material component in the following weight percentages: 1.2% glycerol monostearate, 0.8% beeswax %, Poloxamer 1885%.

[0128] Preparation:

[0129] S2-1. Add the microemulsion prepared in Example 1 into container D, heat to 65-70°C and keep this temperature;

[0130] S2-2. Weigh glyceryl monostearate, beeswax and poloxamer 188 and add to container C, heat to 65-70°C until transparent melt is obtained;

[0131] S2-3. Add the transparent melt in the container C to the microemulsion in the container D, stir and mix to obtain a clear and transparent hot microemulsion;

[0132] S2-4. The hot microemulsion was stirred with a high-speed homogenizer at 18,000 rpm for 5 minutes, and treated with a sonicator with a power of 400 W for 10-20 minutes, followed by cooling in an ice-water bath to obtain a ...

Embodiment 3

[0134] A kind of oleanolic acid microemulsion, including each raw material component of following weight percent, as shown in table 2:

[0135] Table 2

[0136]

[0137]

[0138] Preparation:

[0139] S1-1. Weigh isosorbide dimethyl ether, isopentane glycol, tea tree essential oil, peppermint essential oil, oriental orientalis essential oil and Tween 20, fatty alcohol polyoxyethylene ether (AEO-9), decyl glucoside in a container Mix and stir evenly in A, then add the formula amount of oleanolic acid and stir until completely dissolved to obtain a lipophilic phase;

[0140] S1-2. Add an appropriate amount of water in container B, then add hydroxypropyl chitosan and stir until fully swollen to obtain a water phase;

[0141] S1-3. The lipophilic phase is slowly added to the water phase while stirring to self-emulsify to obtain clear and transparent microemulsion colostrum;

[0142]S1-4. Then use a high-speed homogenizer to stir at 16,000 rpm for 12 minutes to obtain a mi...

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Abstract

The invention belongs to the technical field of cosmetics and skin external preparations, and particularly discloses a microemulsion composition of oleanolic acid as well as a preparation method and application of the microemulsion composition. The microemulsion composition comprises oleanolic acid, a surfactant, a cosurfactant, plant essential oil, water, cyclodextrin and a water-soluble chitosan derivative, and further comprises solid lipid and / or preferable hair growth promoting substances (lupeol, isoimperatorin and icaritin), and other auxiliary materials or additives. The microemulsion composition can be self-emulsified to form a microemulsion or nano-emulsion in which the oleanolic acid is in a dissolved state and the content is relatively high, and can be further used for preparing a nano-structure lipid carrier. The microemulsion composition overcomes the defects that oleanolic acid is poor in solubility and not easy to absorb, meanwhile overcomes the defects that plant essential oil is unstable and insoluble in water, enhances effectiveness and stability, and is simple in preparation method, suitable for industrial production and wide in application prospect.

Description

technical field [0001] The invention belongs to the technical field of cosmetics and the technical field of external skin preparations, and in particular relates to an oleanolic acid micro-emulsion composition and its use for preparing cosmetics and external skin preparations. Background technique [0002] Oleanolic acid is a natural pentacyclic triterpenoid that exists widely in plants. The purified powder of oleanolic acid is white crystal, odorless, tasteless, unstable to acid and alkali, and insoluble in water. [0003] Oleanolic acid has a wide range of active effects, in addition to antibacterial, anti-inflammatory, antioxidant, liver protection, anti-tumor and other effects, some in vitro studies in recent years have shown that oleanolic acid also has many effects on the skin and hair follicles: Oleanolic acid has the functions of promoting collagen production, promoting ceramide production, promoting wound healing, and anti-allergic effects on the skin; and it has b...

Claims

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Application Information

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IPC IPC(8): A61K8/63A61K8/06A61K8/92A61K8/73A61Q19/00A61Q7/00A61Q19/08A61Q5/00A61Q5/12A61Q5/10A61Q5/02A61Q13/00A61K47/28A61K47/44A61K47/40A61K47/36A61K9/107A61K31/56A61P17/00A61P17/14A61P17/10
CPCA61K8/63A61K8/068A61K8/922A61K8/738A61K8/736A61Q19/00A61Q7/00A61Q19/08A61Q5/00A61Q5/12A61Q5/10A61Q19/005A61Q5/02A61Q13/00A61K47/28A61K47/44A61K47/40A61K47/36A61K31/56A61K9/0014A61K9/1075A61P17/00A61P17/14A61P17/10
Inventor 林振放林进发
Owner 泉州达浔生物科技有限公司
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