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Dental stepped degradable magnesium alloy barrier membrane and preparation method thereof

A magnesium alloy and barrier film technology, which is applied in medical science, metal material coating technology, surgery, etc., can solve problems such as stress shielding effect, bone thickening, and easy collapse

Active Publication Date: 2022-07-29
NANCHANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

One type is non-degradable barrier films, such as titanium, stainless steel, cobalt-chromium alloy and other metal barrier films, which are characterized by: good mechanical support performance; but titanium modulus ~ 110GPa, steel ~ 200Gpa, cobalt-chromium alloy ~ 240GP, and tooth Bone modulus ~ 18GPa [Journal of Prosthodontics, 1999, 8: 41] has a large difference, which is prone to stress shielding effect, leading to problems such as bone thickening and chronic inflammation; and requires a second operation to remove it, which increases the treatment cost and pain of the patient
The second category is degradable barrier membranes, such as: polylactic acid PLA, polycaprolactone PCL, polyglycolic acid PGA, collagen membrane, chitosan, etc., which are characterized by: no need for secondary surgery; but poor mechanical support , The mechanical strength loss is too fast during the degradation process, and the bone space is unstable and easy to collapse during the repair period
Shanghai Jiaotong University and Shanghai Ninth Hospital plated a Ca-P layer on the Mg-Zn-Gd barrier film for rabbit skull repair; the degradation rate was much reduced, but the degradation rate was still relatively fast, and air pockets were produced during implantation[Journal of Magnesium and Alloys, 2021, 9, 281]

Method used

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  • Dental stepped degradable magnesium alloy barrier membrane and preparation method thereof
  • Dental stepped degradable magnesium alloy barrier membrane and preparation method thereof
  • Dental stepped degradable magnesium alloy barrier membrane and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] The pure magnesium bar with φ7mm and 20mm length is selected as the raw material.

[0028] Roughness control: ① EDM drilling: according to figure 1 The hole design of the barrier film, the diameter of the molybdenum wire is 0.1mm, the wire speed is less than or equal to 2m / s, the hole is drilled until the hole diameter reaches d = 0.3mm, the hole diameter tolerance is image 3 ;2 Diamond wire cutting: using diamond wire cutting machine, the wire diameter is 0.3mm, the cutting speed is ≤0.25mm / min, the cutting step accuracy is 0.01mm, anhydrous ethanol is the coolant, and the cutting thickness is 0.8mm; ③Polishing: Sand the surface with 3000# sandpaper, then sand the surface with 10000# sandpaper until the surface is smooth and the thickness measured by vernier caliper is 0.5±0.05mm; finally polish to the surface roughness R a =0.39μm, and its metallographic photo is as follows figure 2 shown.

[0029] TiN / TiO 2 The deposition of nanocomposite films includes: ① hydro...

Embodiment 2

[0032] The Mg-3Zn-0.2Ca bar with a length of 7mm and a length of 20mm is selected as the raw material.

[0033] Roughness control: ① EDM drilling: according to figure 1 Barrier membrane hole design, the diameter of molybdenum wire is 0.1mm, the wire speed is ≤2m / s, the hole is punched until the hole diameter reaches d = 0.3mm, the hole diameter tolerance is image 3 ; ②Diamond wire cutting: use a diamond wire cutting machine, the cutting wire is diamond wire, the wire diameter is 0.3mm, the cutting speed is ≤0.25mm / min, the cutting step accuracy is 0.01mm, and anhydrous ethanol is the coolant. The cutting thickness is 0.8mm; ③Polishing: sand the surface with 3000# sandpaper, then sand the surface with 10000# sandpaper until smooth and the thickness measured by vernier caliper is 0.5±0.05mm; finally, polish to the surface roughness R a =0.26μm, and its metallographic photo is as follows figure 2 shown.

[0034] TiN / TiO 2 The deposition of nanocomposite films includes: ① hyd...

Embodiment 3

[0037] The pure magnesium bar with φ7mm and 20mm length is selected as the raw material.

[0038] Roughness control: ① EDM drilling: according to figure 1 Barrier membrane hole design, the diameter of molybdenum wire is 0.1mm, the wire speed is ≤2m / s, the hole is punched until the hole diameter reaches d = 0.3mm, the hole diameter tolerance is image 3 ; ②Diamond wire cutting: use a diamond wire cutting machine, the cutting wire is diamond wire, the wire diameter is 0.3mm, the cutting speed is ≤0.25mm / min, the cutting step accuracy is 0.01mm, and anhydrous ethanol is the coolant. The cutting thickness is 0.8mm; ③Polishing: sand the surface with 3000# sandpaper, then sand the surface with 10000# sandpaper until smooth and the thickness measured by vernier caliper is 0.5±0.05mm; finally, polish to the surface roughness R a =0.20μm, and its metallographic photo is as follows figure 2 shown.

[0039] TiN / TiO 2 The deposition of nanocomposite films includes: ① hydrogen removal ...

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Abstract

The invention provides a dental stepped degradable magnesium alloy barrier membrane and a preparation method thereof. The preparation method comprises the following steps: (1) controlling the roughness of the magnesium alloy barrier film; and (2) depositing the TiN / TiO2 nano composite film. In the step (1), the whole magnesium alloy barrier film is uniformly degraded, and in the step (2), the degradation speed of 4 weeks of in-vivo implantation (or 1 week of in-vitro Hank's 37 DEG C solution) is limited. According to the obtained dental stepped degradable magnesium alloy barrier membrane, the barrier membrane is uniformly degraded after the roughness is controlled; the magnesium alloy barrier membrane has the advantages that the magnesium alloy barrier membrane is implanted in vivo for four weeks (or a Hank's 37 DEG C solution in vitro for one week) after coating, the degradation speed is obviously reduced, and the magnesium alloy barrier membrane is degraded in a slow-to-fast manner after roughness and coating regulation, and is used for dental alveolar bone repair and clinical bone repair of jaw bones, skull bones and the like.

Description

technical field [0001] The invention belongs to the field of biological materials, and relates to a dental guided bone regeneration barrier film. Background technique [0002] Dental implants are recognized by the medical community as an ideal dental restoration method, which can perfectly reproduce the chewing function of the teeth and maintain the aesthetics. It is used by more and more patients. When implementing dental implants, there must be a certain amount of alveolar bone. If there is insufficient alveolar bone, guided bone regeneration (GBR) is required. At this time, it is necessary to implant a barrier membrane to guide the regeneration of periosteal cells and prevent fibroblasts and epithelial cells from entering the defect area. At present, there are two main types of dental clinical barrier films [Chinese Journal of Oral Implantology, 2019, 24(1):44]. One is a non-degradable barrier film, such as titanium, stainless steel, cobalt-chromium alloy and other met...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C23C14/02C23C14/06C23C14/08C23C14/22A61L31/02A61L31/08A61L31/14
CPCC23C14/028C23C14/0641C23C14/083C23C14/22C23C14/0021A61L31/022A61L31/088A61L31/148A61L2420/02
Inventor 罗岚赵嘉成刘勇王绳黄昱旲吴相钢安浩瑾
Owner NANCHANG UNIV
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