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Micro-capsule contg. water soluble beauty-care activity component water nuclear, and composition contg. same

A microcapsule, water-based technology, applied in the field of cosmetic or skin care compositions, can solve the problems of inability to achieve the encapsulation degree, changing the pH value of the composition, unsuitable for stabilizing active components, etc.

Inactive Publication Date: 2005-02-16
LOREAL SA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0015] The applicant has now found that the polymers disclosed in the above mentioned patent documents are not suitable for stabilizing active ingredients, either because they hydrolyze in aqueous media to release organic acids which alter the pH of the composition , or because they cannot achieve a satisfactory degree of encapsulation

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0078] Cytochrome C Microcapsules

[0079] Cytochrome C (commercially available from Sigma, product number C3256) was formulated as a 0.25% by weight aqueous solution. Using a rotor-stator type homogenizer, 5 ml of the above solution was added into 50 ml of dichloromethane containing 5% cellulose acetobutyrate (CAB-381-05®, Eastman Chemical) and emulsified for 5 minutes while keeping the temperature below 25 ℃. This initial emulsion was then dispersed in 500 ml of an aqueous solution containing 1% polyvinyl alcohol (Rhodoviol 4-125, Rhodia Chimie) in a Moritz disperser at room temperature for 20 minutes.

[0080] Using a rotary evaporator (Buchi B-480), the above suspension was evaporated at 40° C. for 5 hours under a pressure of 75 kPa to remove the solvent.

[0081] This gives an aqueous suspension of microcapsules with an average diameter of 22 microns.

[0082] Cytochrome C can be detected on a UV-Vis spectrophotometer at a wavelength of 506 nm.

[0083] The degree o...

Embodiment 2

[0086] Chlorophyllin Microcapsules

[0087] The chlorophyllin was prepared as a 0.1% (weight) aqueous solution. Using a rotor-stator type homogenizer, 5 ml of this solution was emulsified in 50 ml of methylene chloride containing 5% poly(caprolactone) (CAPA640(R), Solvay) for 5 minutes while keeping the temperature below 25°C. This initial emulsion was then dispersed in 500 ml of an aqueous solution containing 1% polyvinyl alcohol (Rhodoviol 4-125, Rhodia Chimie) in a Moritz disperser at room temperature for 20 minutes.

[0088] Using a rotary evaporator (Buchi B-480), the above suspension was evaporated at 40° C. for 5 hours under a pressure of 75 kPa to remove the solvent.

[0089] This gives an aqueous suspension of microcapsules with an average diameter of 15 microns.

[0090] Chlorophyllin can be detected on a UV-Vis spectrophotometer at a wavelength of 405 nm.

[0091] The encapsulation degree is 90%, and the production yield is 100%.

[0092] The resulting microcaps...

Embodiment 3

[0094] Ascorbic Acid Microcapsules

[0095] The ascorbic acid is formulated into an aqueous solution with a concentration of 5% (weight) and a pH value of 6. Using a rotor-stator type homogenizer, 5 ml of this solution was emulsified in 50 ml of methylene chloride containing 5% cellulose levulinate (CAP-482-0.5®, Eastman Chemical) for 5 minutes while keeping the temperature low. at 25°C. This initial emulsion was then dispersed in 500 ml of an aqueous solution containing 1% polyvinyl alcohol (Airvol 203(R), Air Products) and 7% sodium chloride in a Moritz disperser at room temperature for 20 minutes.

[0096] Using a rotary evaporator (Buchi B-480), the above suspension was evaporated at 40° C. for 5 hours under a pressure of 75 kPa to remove the solvent.

[0097] The average size of the obtained microcapsules was 20 microns.

[0098] Ascorbic acid was detected by HPLC at a detection wavelength of 257 nm in a phosphate buffer solution with a concentration of 0.1 mol / l and...

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PUM

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Abstract

The present invention relates to microcapsules with an aqueous core containing at least one water-soluble cosmetic or dermatological active principle, and with a polymeric and / or waxy envelope, in which the said envelope consists of at least one polymer chosen from polycaprolactone, poly(3-hydroxybutyrate), poly ethylene adipate, poly butylene adipate, cellulose esters of at least one C1-C4 carboxylic acid, copolymers of styrene and of maleic anhydride, copolymers of styrene and of acrylic acid, styrene-ethylene / butylene-styrene block terpolymers, styrene-ethylene / propylene-styrene block terpolymers and terpolymers of ethylene, of vinyl acetate and of maleic anhydride, and / or of at least one wax chosen from beeswax, polyglycerolated beeswax, hydrogenated plant oils, paraffin with a melting point above 45 DEG C., and silicone waxes.

Description

technical field [0001] The present invention relates to microcapsules having an aqueous core containing at least one water-soluble cosmetic or skin care active ingredient, to cosmetic or skin care compositions containing the microcapsules and to a process for the preparation of the microcapsules. Background technique [0002] It is well known that active agents in cosmetic or skin care products are microencapsulated for better storage and / or sustained and controlled release. [0003] The method of microencapsulation and its principles are described in detail in, for example, "Microencapsulation, Methods and Industrial Applications", edited by Benita, M. Dekkr, 1996. [0004] In all microencapsulation methods, polymers are used as constituents of the microparticle wall that isolates the active agent from external media. These microparticles can encapsulate water-soluble active agents better than other microporous systems, such as liposomes, which employ a bilayer phospholipi...

Claims

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Application Information

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IPC IPC(8): A61K9/52A61K8/00A61K8/11A61K8/31A61K8/49A61K8/58A61K8/66A61K8/67A61K8/73A61K8/89A61K8/891A61K8/90A61K8/97A61K9/50A61K31/375A61K47/32A61K47/34A61K47/44A61Q19/00B01J13/12C08L83/04C08L83/06
CPCA61Q19/00A61K9/5042A61K8/676A61K8/66A61K2800/58A61K8/494A61K8/11A61K2800/52A61K9/5026A61K2800/412A61P17/00
Inventor 布鲁诺·比亚特里埃里克·勒赫
Owner LOREAL SA
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