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Environment responding aquogel copolymer and its prepn

An environmental response, hydrogel technology, applied in the field of intelligent hydrogel and its preparation, can solve the problems of affecting characteristics, low response speed, difficult to shape, etc., to achieve high mechanical strength and toughness, rapid temperature response, good swelling performance effect

Inactive Publication Date: 2004-09-08
TIANJIN POLYTECHNIC UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, PNIPA hydrogel also has disadvantages: it is too soft in the swollen state, and it is difficult to shape; at the same time, the volume change of the gel is relatively slow
Although this amphoteric hydrogel can overcome the influence of the introduction of salt ions in aqueous solution on its swelling behavior, the process of synthesizing monomers with specific structures is complicated and not universal, so it is difficult to obtain in practice Application (see literature 4 "Thermoreversible swelling behavior of hydrogels based on N-isopropylacrylamide with zwitterioniccomonomer"), Wei Xue, Simon Champ, Malcolm B Hugling. European Polymer Journal, 2001, 37:869-875)
[0009] From the above analysis, it can be seen that the above four types of monomers that can be copolymerized with NIPA have their own limitations, either the LCST is not adjustable, or the response speed is low, which solves certain problems and affects the other characteristics.
In particular, it should be pointed out that the above four types of monomers are all chemically synthesized substances, so these hydrogels have poor biocompatibility, are not degradable, and have average mechanical strength.
This limits its practical application
For example, it cannot be used in separation techniques and new gel machines that require high strength and / or biocompatibility

Method used

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preparation example Construction

[0022] The preparation method of the environment-responsive hydrogel in the invention includes three steps:

[0023] (1) Prepare a mixed solution of dextran and dimethyl sulfoxide. Add the specified mass percentage of dextran and solvent dimethyl sulfoxide into the container, stir at 50-80°C until the dextran is completely dissolved in the solvent and cool to room temperature; the amount of dextran and the amount of dimethyl sulfoxide The ratio is 1g: 10ml;

[0024] (2) Synthesis of dextran derivatives. Under nitrogen atmosphere, add the catalyst 4-dimethylaminopyridine to the mixed solution obtained in step (1), and after it dissolves, add glycidyl methacrylate, stir the mixed solution, and react at room temperature for 24-72 Hours later, add hydrochloric acid to neutralize 4-dimethylaminopyridine to stop the reaction; the resulting reaction mixture is repeatedly washed with absolute ethanol for 3-5 times by precipitation method and then vacuum-dried, and the white powder o...

Embodiment 1

[0028] Under nitrogen atmosphere, 30g of dextran (Dextran 40000) was dissolved in 300ml of dimethyl sulfoxide in a container at 50°C. After it was completely dissolved and cooled to room temperature, 6g of catalyst 4-dimethylaminopyridine was added, and then 8.4ml GMA; the mixed solution was stirred and reacted for 72 hours at room temperature, and then a certain amount of hydrochloric acid was added to neutralize 4-dimethylaminopyridine to stop the reaction. The obtained reaction mixture was repeatedly washed with absolute ethanol for 3 times by precipitation method, and then vacuum-dried, and the obtained white powder was MA-Dex with a=1:3. The above MA-Dex 0.4g and NIPA 3.6g (r=10%) were dissolved in 20ml of deionized water, and then 0.04g of ammonium persulfate was added. Mixed solution filled with N 2 Gas for 10min, then quickly add accelerator N, N, N`, N`-tetramethylethylenediamine 0.10ml, pour it into a mold made of two glass plates, seal it, react at room temperature...

Embodiment 2

[0030] Under nitrogen atmosphere, 20g of dextran (Dextran 40000) was dissolved in 200ml of dimethyl sulfoxide in a container at 50°C. After it was completely dissolved and cooled to room temperature, 4g of catalyst 4-dimethylaminopyridine was added, and then 5.6 ml GMA. The mixed solution was stirred, reacted at room temperature for 48 hours, and then added a certain amount of hydrochloric acid to neutralize 4-dimethylaminopyridine and stop the reaction. The obtained reaction mixture was repeatedly washed with absolute ethanol for 5 times by precipitation method, and then vacuum-dried, and the obtained white powder was MA-Dex with a=1:3. The above MA-Dex 0.8g and NIPA 1.2g (r=40%) were dissolved in 10ml of deionized water, and then 0.02g of ammonium persulfate was added. Mixed solution filled with N 2 Gas for 15 minutes, then quickly add 0.05ml of N, N, N`, N`-tetramethylethylenediamine as an accelerator, pour it into a mold made of two glass plates, seal it, and react at ro...

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Abstract

The present invention relates to one kind of environment responding aquogel copolymer and its preparation process. The aquogel consists of: N-isopropyl acrylamide 10-90 wt% and methacrylate dextran derivative 10-90 wt%. The preparation process of the environment responding aquogel copolymer includes chemical modification of dextran with GMA to synthesize methacrylate dextran derivative, MA-Dex, with reaction activity; and subsequent copolymerization of MA-Dex and NIPA to obtain the said environment responding aquogel copolymer P(NIPA-co-MA-Dex). The aquogel copolymer has high temperature sensitivity and quick responding speed as well as high strength and excellent biocompatibility. The preparation process is simple, needs no special apparatus and is easy to realize in industry.

Description

technical field [0001] The invention relates to an intelligent hydrogel and a preparation method thereof, specifically an environment-responsive N-isopropylacrylamide (N-isopropylacrylamide, NIPA) and a methacrylate dextran derivative (MA-Dex ) copolymerized hydrogel and its preparation method, which belong to the field of functional polymer materials, and the international patent classification number is proposed to be Int.C1 7 C08F20 / 54. Background technique [0002] Smart hydrogels are a type of hydrogels whose properties will change significantly in response to slight physical or chemical stimuli from the external environment. It is a cross-linked hydrophilic polymer network that is insoluble in water but swellable in water. Typical external environmental stimuli that have been studied include temperature, pH, electric field, ionic strength, solvents, reactants, light, and chemicals. Due to the advantages of high water content and good biocompatibility, smart hydroge...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F2/00C08F220/56
Inventor 陈莉董晶
Owner TIANJIN POLYTECHNIC UNIV
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