20 results about "Dextran Derivatives" patented technology

The present invention provides a pressure-sensitive adhesive composition suitable for forming a pressure-sensitive adhesive sheet having a smooth surface. The pressure-sensitive adhesive composition of the present invention includes a β-1,3-glucan derivative G. The pressure-sensitive adhesive composition has a tan δ of 0.7 or more at 200° C. as determined by the following test. Test: a disc-shaped evaluation sample is produced from a pressure-sensitive adhesive composition. The evaluation sample is subjected to a dynamic viscoelasticity measurement to determine a tan δ thereof at 200° C.

The present invention provides a pressure-sensitive adhesive composition suitable for producing a pressure-sensitive adhesive sheet having a low glass transition temperature. The pressure-sensitive adhesive composition according to the present invention includes a β-1,3-glucan derivative G. The β-1,3-glucan derivative G has an acyl group a having a carbon number of 8 or more and an acyl group b having a carbon number different from the carbon number of the acyl group a, and the carbon number of the acyl group b is 8 or more. A pressure-sensitive adhesive sheet 1 according to the present invention is formed from the pressure-sensitive adhesive composition. A laminate 10 according to the present invention includes the pressure-sensitive adhesive sheet 1 and a substrate sheet 2.

The present invention provides a novel pressure-sensitive adhesive composition including a glucan derivative. The pressure-sensitive adhesive composition of the present invention includes a glucan derivative G having a glucoside bond A, and a glucoside bond B having a different bonding form from the glucoside bond A. The glucoside bond A is, for example, a 1,6-glucoside bond. A pressure-sensitive adhesive sheet 1 of the present invention is formed from the pressure-sensitive adhesive composition. A laminate 10 of the present invention includes the pressure-sensitive adhesive sheet 1 and a substrate sheet 2.

The disclosure generally relates to poly alpha-1,3-glucan compositions and articles containing them. In particular interest is comprising poly alpha-1,3-glucan ester derivatives. The poly alpha-1,3-glucan derivatives are useful in thermoprocesses and in particular, injection molding processes.

The invention belongs to the technical field of flocculants, and particularly provides a wastewater treatment flocculant and a preparation method thereof.The preparation method of the wastewater treatment flocculant comprises the following steps that 1, guar gum and isopropyl acrylamide react to prepare a precursor A; guar gum reacts with sodium methacrylate to prepare a precursor material B; and 2) uniformly mixing deionized water, the precursor material A, the precursor material B and a glucan derivative polymer, then adding a monomer and an initiator, and carrying out a photo-initiation reaction, purification and drying to obtain the flocculant. The prepared flocculant has the advantages of good flocculation effect and applicability to a complex sewage system.

To provide a method for introducing a nucleic acid into a floating cell.SOLUTION: The present invention provides a method for introducing nucleic acids into non-adherent cells, comprising the step of contacting nucleic acids with non-adherent cells in solutions comprising dextran derivatives having average molecular weights greater than 70kDa.SELECTED DRAWING: None

The invention relates to the field of biomedical materials, and particularly provides a preparation method of bioactive hydrogel for clinically retaining and slowly releasing medicine liniment.The preparation method comprises the following steps that S1, aminophenylboronic acid is dissolved in water to prepare an aminophenylboronic acid aqueous solution, a glucan derivative is added, after heating and stirring reaction, a product is collected, washed and dried, and the hydrogel is obtained; a hydrogel precursor is obtained; s2, polyphenol substances and polysaccharide substances are added into 0.5 wt%-20 wt% of an aqueous solution of the hydrogel precursor, after stirring reaction is conducted, 0.02 wt%-8 wt% of a hydrazide aqueous solution is added into the aqueous solution, ultrasonic treatment is conducted, standing is conducted, and the bioactive hydrogel can be obtained. By optimizing the variety and dosage of the components, the hydrogel can be attached to the skin, retention of the traditional Chinese medicine liniment at the focus of the skin is helped, and the action time of the liniment medicine is prolonged to 12-24 h.

An adhesive composition includes a beta-1,3-glucan derivative having an acyl group introduced in a beta-1,3-glucan, and a petroleum-based resin. An adhesive tape (1) is provided with an adhesive layer (3) formed of the adhesive composition.

The application discloses a temozolomide dexchlorpheniramine derivative and application thereof in preparation of an antitumor drug, and is based on new cognition of a TMZ drug resistance mechanism, designs and synthesizes two temozolomide derivatives. The target compounds retain the alkylating activity of TMZ, and metabolites do not produce 5-amino-imidazole-4 amide (AICA), but produce dexchlorpheniramine derivatives of AICA. Thus, the TMZ chemotherapy sensitivity is enhanced, and the TMZ drug resistance of glioma is delayed or reversed. The application first reconstructs the TMZ molecule from the metabolic product level, breaks through the action mode of the inherent drug resistance, and provides a brand-new drug design idea for overcoming the TMZ drug resistance. A new generation of TMZ derivative drugs can be developed, a single drug or a combined treatment scheme with higher efficacy and lower drug resistance is realized, and more breakthrough treatment options are provided for GBM patients.

The invention provides injectable beta-glucan hydrogel with an immunologic adjuvant function as well as a preparation method and application of the beta-glucan hydrogel, and relates to the field of biological medicines. The hydrogel is a macromolecular network which is formed by crosslinking an aldehyde group-containing beta-glucan derivative and an amino-containing polymer through a Schiff base bond and has a remarkable immunologic adjuvant function. The hydrogel and the drug-loading sustained-release system thereof can be directly implanted into a focus position through a conventional medical injector, immune cells are remarkably activated, and the immunogenicity of tumor cells is enhanced, so that the immune microenvironment of solid tumors is effectively adjusted. Particularly, when the beta-glucan derivative hydrogel and the drug sustained-release system thereof provided by the invention are applied in combination with radiotherapy, the beta-glucan derivative hydrogel and the drug sustained-release system thereof show excellent tumor treatment efficiency. The preparation process is simple and mild, the obtained hydrogel has good biocompatibility and controllable drug release characteristics, and a novel and efficient adjuvant therapy strategy is provided for tumor immunotherapy.

Disclosed herein are compositions comprising (i) an insoluble alpha-glucan and soluble alpha-glucan derivative, or (ii) an insoluble alpha-glucan and additive. These compositions can be in the form of particles, for example, such as particles comprising insoluble alpha-glucan coated with a soluble alpha-glucan derivative and / or additive. Methods are further disclosed for preparing these compositions, as well as various applications of using them.

Disclosed herein is a method of treating a surface. Such a method can comprise at least: (a) providing a liquid composition comprising at least a solvent, antimicrobial agent, and alpha-glucan derivative, and (b) contacting the liquid composition with a surface, thereby providing antimicrobial activity to the surface. Further disclosed are compositions comprising various alpha-glucan derivatives, and applications of using these derivatives.

The present invention provides a method for introducing a nucleic acid into a suspension cell, the method comprising a step for bringing the nucleic acid into contact with the suspension cell in a solution containing a dextran derivative having an average molecular weight of more than 70 kDa.

Provided is a galactoxyloglucan derivative in which hydrogen in at least some of a plurality of hydroxyl groups of galactoxyloglucan are substituted with an acyl group, said galactoxyloglucan derivative having one kind of the acyl group that is represented by R1-CO- (where R1 is an alkyl group having 3-17 carbon atoms).

The disclosure relates to poly alpha-1,6-glucan derivatives comprising poly alpha-1,6-glucan substituted with at least one organic group linked to the poly alpha-1,6-glucan through a linkage moiety selected from ether, sulfonyl, carbonate, or carbamoyl / carbamate, and having a degree of substitution of about 0.001 to about 3.0. The poly alpha-1,6-glucan comprises a backbone of glucose monomer units wherein greater than or equal to 40% of the glucose monomer units are linked via alpha-1,6 glycosidic linkages, and optionally at least 5% of the backbone glucose monomer units have branches via alpha-1,2 and / or alpha-1,3 glycosidic linkages. Compositions comprising a poly alpha-1,6-glucan derivative can be useful in various applications.

A laundry care or dish care composition can include a poly alpha-1,6-glucan derivative, wherein the poly alpha-1,6-glucan derivative includes: (i) a poly alpha-1,6-glucan backbone of glucose monomer units; and (ii) at least one hydrophobic organic group linked to the poly alpha-1,6-glucan backbone through an ether (—O—) linkage moiety; wherein, the poly alpha-1,6-glucan backbone has a weight average degree of polymerization of at least 5; wherein, the poly alpha-1,6-glucan derivative has a degree of substitution of ether linkage moiety of from 0.20 to 1.00; wherein the poly alpha-1,6-glucan derivative is substantially free from hydrophilic substitution.

A laundry care or dish care composition can include a poly alpha-1,6-glucan derivative, wherein the poly alpha-1,6-glucan derivative includes:(i) a poly alpha-1,6-glucan backbone of glucose monomer units, wherein greater than or equal to 80% of the glucose monomer units are linked via alpha-1,6 glycosidic linkages, and wherein from about 10% or less of the glucose monomer units are linked via alpha-1,3 glycosidic linkages, 1,2 glycosidic linkages, and / or 1,4 glycosidic linkages; and(ii) at least one organic group linked to the poly alpha-1,6-glucan backbone through a linkage moiety;wherein, the poly alpha-1,6-glucan backbone has a weight average degree of polymerization of at least about 5;wherein, the poly alpha-1,6-glucan derivative has a degree of substitution of linkage moiety of from about 0.20 to about 1.00.

The application provides a modified dextran, a T1 weighted iron-based contrast agent and a preparation method and application thereof. The modified dextran template has a general structure (I), and the preparation method comprises the following steps: esterification reaction of hydroxyl in dextran and a dicarboxylic acid, a diacyl halide or a dicarboxylic anhydride containing an olefin double bond in a polar solvent to generate a carboxyl dextran derivative containing an olefin double bond; the carboxyl dextran derivative containing the olefin double bond is subjected to a thiol-alkene click reaction with a monovalent carboxylic acid containing a thiol group to generate the modified dextran with a dicarboxylic acid functional group. The T1 weighted iron-based contrast agent prepared by using the modified dextran as a template comprises iron oxide nanoparticles and the modified dextran; wherein the iron oxide nanoparticles are wrapped in the modified dextran, and the iron oxide nanoparticles and the modified dextran are connected through a chemical chelate bond. The T1 weighted iron-based contrast agent has small toxic and side effects and excellent magnetic resonance imaging performance.

The present invention provides a hot melt adhesive having high sustainability and excellent adhesiveness. The present invention provides a hot melt adhesive which contains a beta-1, 3-glucan derivative and has a compression-shear bonding strength in a specific range with respect to a wood sheet.