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Electrostatic self-assembly process of preparing multiple medicine controlled releasing coating in exponential increase characteristic

A technology of electrostatic self-assembly and exponential growth, which is used in drug combinations, pharmaceutical formulations, anti-tumor drugs, etc., to achieve the effects of simple process, increased drug loading, and simple loading.

Inactive Publication Date: 2006-03-01
ZHEJIANG UNIV
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Problems solved by technology

Although the loading of drugs in the multilayer film can be regulated by simply controlling the number of assembled layers, since the electrostatic layer-by-layer assembly is assembled at the nanometer level, how to increase the drug loading and enrich the means of controlled release of drugs is a layer-by-layer problem. Key Issues in the Study of Layer-Assembled Coatings

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  • Electrostatic self-assembly process of preparing multiple medicine controlled releasing coating in exponential increase characteristic

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preparation example Construction

[0021] 1. For the preparation of multilayer films with exponential growth characteristics, first use various surface modification techniques to obtain a charged surface with positive or negative charges on the surface of polyurethane, polyvinyl chloride, polyester, silicone rubber or medical 316L stainless steel materials, The following weak polyelectrolytes are used for direct assembly, including one or more mixtures of polyethyleneimine, polylysine, chitosan, polyglutamic acid, hyaluronic acid, and sodium alginate. Using the electrostatic self-assembly method to alternately assemble on the medical device to obtain a multilayer film with exponential growth characteristics, the thickness can reach 0.1-120 microns in 10-50 alternating coatings.

[0022] 2 Multilayer film drug loading, immerse the prepared multilayer film with exponential growth characteristics in the charged drug aqueous solution with a concentration of 0.001mg / ml-10g / ml, adsorption equilibrium for 1-2000 minute...

Embodiment 1

[0025] First immerse the medical 316L stainless steel in 0.01-2mg / ml polyethyleneimine aqueous solution for 5-10 minutes, wash it with deionized water, and dry it with nitrogen to obtain the surface of polyethyleneimine physical adsorption, which is positively charged under the condition of aqueous solution . Soak the positively charged material above in 0.01-10 mg / ml sodium alginate aqueous solution for 5-10 minutes, wash it with deionized water, dry it with nitrogen, repeat the above process to obtain polyanionic sodium alginate and polycationic polyethyleneimine 2 -50 layers of alternating coating surface. Tracking with a quartz microbalance shows that the weight of the multilayer film assembly increases exponentially with the number of layers assembled. Ellipsometer measurements show that the thickness of the multilayer film can reach 0.1-20 microns within 20 layers. The multilayer film is soaked in 0.01-10 mg / ml aqueous solution of dexamethasone, which has an anti-stenos...

Embodiment 2

[0027] First immerse medical 316L stainless steel in 10-50mM polylysine aqueous solution for 5-30min, wash with deionized water, then blow dry with nitrogen, and then immerse in 20-40mg / ml polyglutamic acid aqueous solution for 20-30min Minutes, rinsed with deionized water, blown dry with nitrogen, and repeated the above process to obtain 2-80 layers of alternately coated surfaces of polyanionic polyglutamic acid and polylysine. Tracking with a quartz microbalance shows that the weight of the multilayer film assembly increases exponentially with the number of layers assembled. Ellipsometer measurements show that the thickness of the multilayer film can reach 20-100 microns within 50 layers. Immerse this multilayer film in the aqueous solution of 10-50 mg / ml small low molecular weight heparin, which has anticoagulant effect, for 30-60 minutes, and obtain the heparin release experiment of drug-loaded multilayer film, which shows that the multilayer film can be stable within 50 da...

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Abstract

The electrostatic self-assembly process of preparing multiple medicine controlled releasing coatings in exponential increase characteristic includes the following steps: 1. alternatively adsorbing weakly polymerized anion and cation in volume concentration of 0.001-1000 mg / ml to form the multiple coatings in exponential increase characteristic; 2. soaking the multiple coatings in exponential increase characteristic inside charged medicine aqua of in volume concentration of 0.001-10,000 mg / ml for balance adsorption of 1-2000 min, washing with distilled water and blowing with nitrogen to dry. The present invention are forms the polymer coatings in water solution condition, and makes it possible to obtain stable medicinal polymer coatings on the surface of biomedical device with complicated structure in effectively improved biocompatibility of material.

Description

technical field [0001] The invention relates to a method for preparing an exponential growth characteristic multilayer drug release coating by electrostatic self-assembly. Background technique [0002] Biomedical devices, especially medical implants and interventional therapy devices, can form a long-acting, targeted drug delivery system. Local high-concentration drugs can improve the effectiveness of treatment and reduce systemic toxicity. These advantages of the drug controlled release system not only improve the traditional treatment methods but also solve some new diseases. However, there are still many challenges in this method, the most important one is how to develop a new drug controlled release system, which can be used to precisely control drug loading and drug release. [0003] The layered hydrogel multilayer films obtained by layer-by-layer assembly also provide a good means for the design of drug-controlled release coatings. Although the loading of drugs in th...

Claims

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Application Information

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IPC IPC(8): A61K9/70A61K45/06A61K31/616A61K31/5575A61K31/704A61K31/727A61K31/7048A61K31/573A61P7/02A61P35/00A61P31/00A61P43/00
Inventor 计剑谭庆刚沈家骢
Owner ZHEJIANG UNIV
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