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Diclofenac salt pleximetric paste and its production

A diclofenac salt and transdermal patch technology, applied in the field of medicine, can solve the problems of poor transdermal effect, difficulty in penetrating the skin barrier, and low solubility, and achieve long-lasting and stable curative effect, good flexibility, and convenient use

Inactive Publication Date: 2011-08-31
SHENYANG PHARMA UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Diclofenac sodium and diclofenac potassium are widely used clinically in the treatment of diseases such as joint pain and arthritis, but the solubility of these two drugs is small, the transdermal effect is poor, and it is difficult to penetrate the skin barrier. Therefore, it is considered to synthesize several new diclofenac Alkanolamine salts to solve the above problems

Method used

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  • Diclofenac salt pleximetric paste and its production
  • Diclofenac salt pleximetric paste and its production
  • Diclofenac salt pleximetric paste and its production

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] prescription:

[0023] diclofenac potassium

[0024] Process: Dissolve the acrylic resin copolymer in a mixed solvent (acetone: isopropanol: ethanol), and add the main drug, succinic acid, ethanol, isopropanol, glycerin, borneol, dibutyl sebacate, spit Temperature 80, PEG400, etc. are fully mixed, transferred and coated on silicone oil paper, dried at 70°C, then compounded with non-woven backing material, punched and cut into a certain size and specification, and the product is ready.

example 2

[0026] prescription:

[0027] Diclofenac pyrrolidine

[0028] Menthol

[0029] Process: Dissolve the acrylic resin copolymer in a mixed solvent (acetone: isopropanol: ethanol), and add the main drug, succinic acid, propylene glycol, glycerin, menthol, borneol, glycerol monolaurate, Tween 20 after complete dissolution , PEG300, etc., fully mixed, transferred and coated on silicone oil paper, dried at 70°C, then compounded with non-woven fabric backing material, punched into a certain size and specification, and that is ready.

example 3

[0031] prescription:

[0032] Diclofenac diethylamine

[0033] Process: Dissolve the acrylic resin copolymer in a mixed solvent (acetone: isopropanol: ethanol), and add the main drug, succinic acid, isopropanol, isopropyl myristate, azone, phthalic acid after completely dissolving Dibutyl ester, Tween 60, PEG400, etc. are fully mixed, transferred and coated on silicone oil paper, dried at 70°C, then compounded with non-woven backing material, punched into a certain size and specification, and ready.

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PUM

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Abstract

A transdermal paster of diclofenac salt is composed of substrate layer, medicinal layer and antisticking layer. Said medicine layer consisting of diclofenac salt, matrix (acrylic resin and pressure sensitive adhesive No.4), transdermal osmosis promoter and plasticizer. Said diclofenac salt is prepared through respectively dissolving diclofenac, diethylamine, diethanolamine, triethanolamine and pyrrolidine in acetone, mixing and ultrasonic stirring.

Description

Technical field: [0001] The invention relates to the technical field of medicine, in particular to a transdermal patch of diclofenac and a preparation method thereof. Background technique: [0002] Non-steroidal anti-inflammatory analgesics, its mechanism of action is similar to that of acetylsalicylic acid, which can selectively cut off the action of prostaglandin cyclooxygenase in the metabolic series of arachidonic acid, block the synthesis of prostaglandin E2, and then play an anti-inflammatory role. Its anti-inflammatory and antipyretic effects are 2-2.5 times stronger than indomethacin and 26-50 times stronger than aspirin. It is mainly used clinically for the treatment of rheumatoid arthritis, osteoarthritis, ankylosing spondylitis; various soft tissue swelling and pain, including low back pain, frozen shoulder, synovitis, tendon and tenosynovitis, cervical spondylosis; soft tissue injury, including contusion , sprains, lacerations, strains; it also has a good therap...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/196A61K9/70A61K9/06A61K47/32A61K47/18A61K47/10A61K47/14A61P19/02A61P29/00A61P17/00A61P35/00A61P1/02
Inventor 方亮刘宇何仲贵
Owner SHENYANG PHARMA UNIVERSITY
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