Method for preparing tinidazole dispersion tablet and use

A technology of tinidazole and dispersible tablets, which is applied in the field of preparation of tinidazole dispersible tablets, can solve the problems of low bioavailability and low absorption, and achieve the effects of convenient carrying and storage, fast absorption and simple preparation process

Inactive Publication Date: 2007-04-11
陈亦林
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since the structure of tinidazole is to replace imidazoles, it is slightly soluble in water, so the absorption in the body is low, and the bioavailability of general tablets is not high.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] The prescription composition of tinidazole dispersible tablet of the present invention:

[0020] Tinidazole 200g

[0021] Microcrystalline Cellulose 110g

[0022] Low-substituted hydroxypropyl cellulose 30g

[0023] Micronized silica gel 35g

[0024] Cross-linked polyvinylpyrrolidone 25g

[0025] Croscarmellose Sodium 30g

[0026] Magnesium Stearate 2g

[0027] Aspartame 2g

[0028] Proper amount of ethanol

[0029] Makes 1000 pieces

[0030] The preparation method is as follows: the raw material tinidazole is fully mixed with some auxiliary materials, and the powder is fully pulverized in a small desktop ultrafine pulverizer. Make the powder pass through a sieve of more than 100 meshes, add fillers, disintegrants, and sweeteners, mix well, use a certain amount of ethanol as a wetting agent to make soft materials, and make the soft materials evenly stirred into granules, and place Dry in a circulating blast drying oven at 60-80°C. Add the dried granules to mag...

Embodiment 2

[0032] The prescription composition of tinidazole dispersible tablet of the present invention:

[0033] Tinidazole 250g

[0034] Lactose 100g

[0035] Low-substituted hydroxypropyl cellulose 30g

[0036] Micronized silica gel 35g

[0037] Cross-linked polyvinylpyrrolidone 25g

[0038] Croscarmellose Sodium 30g

[0039] Poloxamer 10g

[0040] Magnesium Stearate 2g

[0041] Aspartame 2g

[0042] Proper amount of ethanol

[0043] Makes 1000 pieces

[0044] The preparation method is as follows: the raw material tinidazole is fully mixed with some auxiliary materials, and the powder is fully pulverized in a small desktop ultrafine pulverizer. Make the powder pass through a sieve of more than 100 meshes, add fillers, disintegrants, and sweeteners, mix well, use a certain amount of ethanol as a wetting agent to make soft materials, and make the soft materials evenly stirred into granules, and place Dry in a circulating blast drying oven at 60-80°C. Add the dried granules t...

Embodiment 3

[0046] The prescription composition of tinidazole dispersible tablet of the present invention:

[0047] Tinidazole 500g

[0048] Compressible starch 100g

[0049] Low-substituted hydroxypropyl cellulose 30g

[0050] Micronized silica gel 30g

[0051] Cross-linked polyvinylpyrrolidone 25g

[0052] Croscarmellose Sodium 30g

[0053] Tween-80 10g

[0054] Magnesium Stearate 2g

[0055] Aspartame 2g

[0056] Proper amount of ethanol

[0057] Makes 1000 pieces

[0058]The preparation method is as follows: the raw material tinidazole is fully mixed with some auxiliary materials, and the powder is fully pulverized in a small desktop ultrafine pulverizer. Make the powder pass through a sieve of more than 100 meshes, add fillers, disintegrants, and sweeteners, mix well, use a certain amount of ethanol as a wetting agent to make soft materials, and make the soft materials evenly stirred into granules, and place Dry in a circulating blast drying oven at 60-80°C. Add the dried ...

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PUM

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Abstract

The invention discloses a preparation method and application for tinidazole dispersing tablet. Said tinidazole dispersing tablet in the invention has merits of convenient for use, fast absorption, high biological utilization ratio, etc. also featuring simple technique , stable quality, convenient for carrying and storing. The amount of tinidazole contained in each tablet of Said tinidazole dispersing tablet in the invention can be 0.2g.,0.25g.,0.5g. The main clinical use for said medicine is applying to all sorts of infection from anaerobe, colon and rectum operation, operation for gynecology and obstetrics, etc.

Description

technical field [0001] The invention relates to a preparation method and application of tinidazole dispersible tablets. Background technique [0002] Tinidazole, its chemical name is: 2-methyl-1-[2-(ethylsulfonyl)ethyl]-5-nitro-1H-imidazole. For various anaerobic infections, such as sepsis, osteomyelitis, abdominal infection, pelvic infection, pulmonary bronchial infection, pneumonia, sinusitis, skin cellulitis, periodontal infection and postoperative wound infection; for colorectal surgery, Preoperative prophylaxis for obstetrics and gynecology surgery and oral surgery; for the treatment of intestinal and extraintestinal amoebiasis, vaginal trichomoniasis, giardiasis, Gardnerella vaginitis, etc.; it can also be used as a Nitazole substitutes are used in the treatment of gastric antral inflammation and peptic ulcer caused by Helicobacter pylori. Tinidazole has high activity against protozoa and anaerobic bacteria. It has antibacterial activity against Bacteroides such as ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4164A61K9/20A61P31/10A61P19/08A61P1/02A61P1/00A61P11/00A61P15/00
Inventor 陈亦林
Owner 陈亦林
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