Topical composition for treating pain
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example 1
Administration of LV with / without an Active Agent to Normal Control Human Patient
[0109]Methods and Materials[0110]a) Pluronic 20% with 750 mg lactose (Weise compounding pharmacy)[0111]b) Vanpen (Weise compounding company)[0112]c) PLO gel (Weise compounding company)—combination of soy lecithin (PCCA) dissolved in 20% pluronic gel made from 405 powder in a ratio of 25% lecithin to 75% pluronic gel[0113]d) Lecithin soya dissolved in isopropyl myristate (Weise compounding company)[0114]e) PLO (Advanced Rx compounding pharmacy)—combination of lactose (750 mg) with propylene glycol to we, 9 mL soy lecithin isopropyl palmitate and 20% pluronic gel (30 mg)[0115]Atenolol (Advanced Rx compounding pharmacy)[0116]Clonidine (Advanced Rx compounding pharmacy)[0117]Nitrobid[0118]Surgilube (applied as control)
[0119]Formulations were applied to skin with a tongue depressor.
[0120]Treatment and Observation
[0121]Application of (a) on skin resulted in numbness similar to that produced by lidocaine.
[0122...
example 2
Administration of LV with / without an Active Agent to Human Patient with Neck Pain
[0126]Materials and Methods
[0127]Formulations were as in Example 1.
[0128]Patient presented with stiff neck with an inability to rotate it past 70 degrees to the right and a rotator cuff tendonopathy. Pain Level—4 / 10. Stiffness with an inability to move her shoulder past 70 degrees.
[0129]Treatment and Observation
[0130]Adding (e) resulted in a very slight effect on the shoulder.
[0131]Adding (c) reduced the pain to 3 / 10 and made shoulder more mobile. Adding (d) seemed to have no effect.
[0132]Adding (e) plus Atenolol 25 mg dissolved in lactose, propylene glycol, soy lecithin / isopropyl palmitate, 20% pluronic gel had a strong effect reducing pain to 0.5 / 10 and made her shoulder much more mobile.
[0133]Adding to (e) clonidine 0.8 mg dissolved in lactose, propylene glycol, soy lecithin / isopropyl palmitate, 20% pluronic gel mixed with 2% nitrobid made the pain disappear completely and restored full mobility. In ...
example 3
Administration of LV with / without an Active Agent to Human Patient with Shoulder and Neck Pain from Tendonopathy
[0134]Materials and Methods
[0135]Formulations were the same as in Example 1.
[0136]The patient presented with Pain level=9 / 10 on shoulder / neck pain from a rotator cuff tendonopathy and inability to move his shoulder past the horizontal. Pain Level=7 / 10 left knee pain due to patellofemoral syndrome; Pain level=9 / 10 from a left sacroiliac strain.
[0137]Treatments and Observation
[0138]Shoulder: Applying 25 mg Atenolol dissolved in (e) decreased pain to 5 / 10 and patient noted that his skin felt warm and mobility was improved.
[0139]The clonidine+nitrobid combination was added with no change.
[0140]Then VanPen gel was added and pain disappeared with full mobility remaining.
[0141]Knee: Adding (e) decreased pain to 2 / 10 with no change in mobility. Clonidine 0.6 mg+nitrobid (2% nitrate) were applied with no change in pain or mobility.
[0142]Back (sacroiliac strain): Applied (e) and pai...
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