Abuse resistant opioid drug-ion exchange resin complexes having hybrid coatings

a technology of opioid drug and resin complex, which is applied in the direction of drug composition, dispersed delivery, synthetic polymeric active ingredients, etc., can solve the problems of particular abuse of opioid drugs, inability to easily extract opioid drugs, and at times associated side effects of opioid drugs, etc., and achieves favorable abuse resistance properties
US20120148672A1Inactive Publication Date: 2012-06-14TRIS PHARMA
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
TRIS PHARMA
Publication Date
2012-06-14
Estimated Expiration
Not applicable · inactive patent
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Abstract

A sustained release formulation for opioid drugs is described. The formulation contains an opioid-ion exchange resin complex having a hybrid coating. The hybrid coating contains a cured polyvinylacetate polymer and a pH-dependent enteric coating layer mixed therein. Also provided are methods of making and using same.
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Description

CROSS-REFERENCE TO RELATED APPLICATIONS

[0001] This application is a continuation of U.S. patent application Ser. No. 12 / 154,970, filed May 28, 2008, which is an application that claims the benefit under 35 USC 119(e) of U.S. Provisional Patent Application No. 60 / 941,169, filed May 31, 2007, now expired.BACKGROUND OF THE INVENTION

[0002] Opioids are commonly prescribed because of their effective analgesic, or pain-relieving, properties. Medications that fall within this class, referred to as prescription narcotics, include morphine sulfate (e.g., Kadian®, Avinza™), codeine salts, oxycodone HCl (e.g., OxyContin™, Percodan™, Percocet™), and related drugs. For example, OxyContin™ tablets are presently commercially available in 10, 20, 40, 80, and 160 milligrams forms. Morphine, for example, is often used before and after surgical procedures to alleviate severe pain. Codeine, on the other hand, is often prescribed for mild pain. In addition to their pain-relieving properties, some of these ...

Claims

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