The invention discloses a cement stabilized base material, a preparation, an application and a preparation method of a road base. The cement stabilized basic material comprises the following materials: 1%-3% of basic slag and 1%-3% of cement and base materials, wherein the basic materials comprises 0.5%-8% of desulfurization gypsum and 92%-99.5% of crushed stone in mass percentage of the basic materials. The preparation method of the cement stabilized base material comprises the step of uniformly mixing the components. According to the preparation method of the road base, the road base is prepared from the cement stabilized base material with the conventional preparation process and conditions. The cement stabilized base material has the advantages as follows: the material cost is reduced, the service life of a road structure is prolonged, the economic benefit is increased, the cement setting time is delayed, the strength, the airtightness, the water retention, the water resistance, the shrinkage crack resistance, the freeze-thaw resistance, the moisture damage resistance and sulfate corrosion resistance of the material are improved, novel application of the desulfurization gypsum is exploited, and the environment is protected effectively.