30 results about "Prostaglandin D2 receptor" patented technology

The present invention relates to (3-amino-1,2,3,4-tetrahydro-9H-carbazol-9-yl)-acetic acid derivatives of Formula (I) wherein R1, R2, R3, R4, R5 and R6 are as described in the description and their use as prostaglandin receptor modulators, most particularly as prostaglandin D2 receptor modulators, in the treatment of various prostaglandin-mediated diseases and disorders, to pharmaceutical compositions containing these compounds and to processes for their preparation.

The present invention is directed to a substituted pyrimidine compound of formula (I) as set forth herein, or an enantiomer thereof, or a prodrug or a pharmaceutically acceptable salt thereof, or a pharmaceutical composition comprising such a compound. The invention also includes a method of treatment of a patient by the administration of a pharmaceutically effective amount of such a compound. Formula (I), wherein m and n, independently of each other, are selected from the integers 0, 1, 2 or 3; X and Y, independently of each other, are selected from CRR, NR or O, wherein X and Y cannot both be O; or X and Y, taken together with the bond between them, form a phenyl group optionally substituted by one to four R groups; each Z, independently of each other, is CRR; R, R and R, independently of each other, are selected from the group consisting of H, halogen, aryl, amino, optionally substituted alkyl, optionally substituted alkoxy, and carboxy; wherein optionally substituted alkyl, may be substituted by one to three of the same or different of halogen, carboxy, cyano, hydroxy, amino or aryl.

The present invention relates to phenyl-substituted heterocyclic derivatives of formula (I), wherein Z, n, m, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 and R 8 as described herein, and as prostaglandin receptor modulators, most particularly as prostaglandin D 2 Use of receptor modulators in treating various prostaglandin-mediated diseases and conditions, pharmaceutical compositions containing these compounds and preparation methods thereof.

The invention provides a simple preparation method of a prostaglandin D2 receptor inhibitor compound. The compound is obtained by using 4-methylsulfonyl-2-trifluoromethylbenzylamine (II) and 3-acetylglutaric acid diester (III) as raw materials, carrying out condensation and cyclization, carrying out an addition reaction with 2-halogenated acrolein, carrying out a pyridine cyclization reaction withammonia and finally carrying out hydrolysis and hydrochloric acid acidification. The method of the invention has the advantages of simple operation, mild reaction conditions, less three wastes, environmental protection, cheap and easily available raw materials, low cost, high reaction selectivity, less by-products, simple purification and high yield and purity, and facilitates the industrial production of the prostaglandin D2 receptor inhibitor compound Fevipiprant.

The invention relates to methods for neuroprotection, promoting survival of motor neurons and the treatment of motor neuron diseases by preventing cell signaling through the classic prostaglandin D2 receptor DP1.