The invention discloses a device for detecting the airtightness of a workpiece, which belongs to the field of airtightness detection. The device comprises a vacuum box, a helium mass spectrometer leakdetector, a first vacuum pump, an air blowing assembly and a helium filling assembly, the vacuum box comprises an upper box cover and a lower box plate, a vacuum cavity is formed between the upper box cover and the lower box plate, an air inlet of the helium mass spectrometer leak detector is communicated with the vacuum cavity, and an air outlet of the helium mass spectrometer leak detector is communicated with an air inlet of the first vacuum pump; the air blowing assembly comprises an air blowing bottle, a first pressure regulating valve and a first electromagnetic valve, the air blowing bottle is communicated with an air inlet of the first pressure regulating valve, an air outlet of the first pressure regulating valve is communicated with an air inlet of the first electromagnetic valve, and an air outlet of the first electromagnetic valve is communicated with the vacuum cavity. According to the device provided by the invention, high-speed flowing gas is blown in through the gas blowing assembly, and the gas has a driving effect on residual helium in the vacuum cavity, so that the residual helium is rapidly cleaned under the vacuumizing effect of the first vacuum pump.