The invention relates to a large handling capacity photocatalytic reactor for wastewater degradation by automatic stop at a process ending, and belongs to the technical field of wastewater treatment. Existing related background technologies have the problems of loss of nanometer photocatalyst, microwave energy dissipation, small wastewater handling capacity of single tank of the reactor, insufficient large circulating strength of inner liquid, difficult of distinguishing reaction ending, incapability of in-situ strong dissipation of catalyst conglobation and the like. The problems are solved by the scheme. In the scheme, a metal cage is used to constrain microwave, so as to greatly expand the reactor. According to the structure of the reactor, the large circulation of inner liquid is strengthened. An external cascaded three-level back-wash filter is beneficial for finely intercepting catalyst particles. The catalyst conglobation can be strongly dissipated in situ due to the structure, and meanwhile, an ultrasonic cleaning quartz tube is arranged. According to the structure, associated power supply can be automatically and immediately closed when the degradation reaction reaches the ending, so that energy injection is stopped, meanwhile, residual ozone generating process is terminated, and therefore, secondary pollution can be avoided.