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Biodegradable active medical tissue adhesive and its preparation method

A tissue adhesive and biodegradable technology, which can be used in pharmaceutical formulations, surgical adhesives, applications, etc., can solve problems such as detrimental to cells, release of toxic monomers, and decreased biological activity of bone cement.

Inactive Publication Date: 2009-09-16
广州暨科拓源生物材料科技开发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] (1) PMMA is used as the matrix phase, and some inherent shortcomings of PMMA cannot be avoided, such as difficulty in absorption, strong heat release during biocuring, release of toxic monomers, etc.
[0009] (2) The bio-inorganic filler is mainly artificially synthesized hydroxyapatite sintered at high temperature. The biocompatibility of HAP and the adsorption capacity of calcium ions will be significantly reduced during high-temperature treatment, which will inevitably lead to the loss of bone cement. decline in biological activity
Detrimental to cells, tissue growth into defect site
[0011] (4) In addition, the mechanical strength of this type of composite bone cement needs to be further improved

Method used

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  • Biodegradable active medical tissue adhesive and its preparation method
  • Biodegradable active medical tissue adhesive and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0082] 0.22g macromonomer (MC-5), 0.34g degradable cross-linking agent were dissolved in 0.44g vinylpyrrolidone monomer, and 0.0075g benzoyl peroxide and 30ppm hydroquinone were added to obtain uniform and stable Clear Solution Component A.

[0083] When bonding skin lacerations, the operator first cleans up the wound thoroughly, without anesthesia and hemostasis, and uses the forefinger and thumb of the left hand to press lightly at a distance of 0.16 to 0.18 cm from the wound edge, which plays the role of oppression and hemostasis, and can Align the edges together. Drop 0.0050g of N,N-dimethyl-p-aniline into component A, mix well within 1min, and drop it on the wound so that it can completely cover the wound. After 2min to 3min, two fingers can slowly Loosen in a criss-cross pattern, and cover the wound with gauze after observing that the wound is no longer bleeding or splitting. After testing: the wound was completely absorbed and degraded after 8 weeks, and tissue sectio...

Embodiment 2

[0085] Dissolve 0.20g macromer (MC-3), 0.40g degradable cross-linking agent in 0.40g vinylpyrrolidone monomer, add 0.0075g benzoyl peroxide and 30ppm hydroquinone and mix to obtain uniform and stable Clear Solution Component A. In ophthalmic surgery, after the small and irregular corneal wound is sutured, add 0.005g N, N-dimethyl-p-aniline to component A, mix well within 1mim, drop into the wound that cannot be completely closed after suturing, 2min-3min Form a transparent film, which can effectively prevent the leakage of aqueous humor.

Embodiment 3

[0087]Dissolve 0.20g macromer (MC-5), 0.35g degradable cross-linking agent in 0.45g vinylpyrrolidone monomer, add 0.0075g benzoyl peroxide and 30ppm hydroquinone to obtain uniform and stable Clear solution.

[0088] New Zealand white rabbits were anesthetized and fixed in the supine position. According to the principle of aseptic technique, a midline incision was made on the upper abdomen to enter the abdominal cavity, and the upper part of the small intestine was cut off. Add 0.0050 g of N,N-dimethyl-p-aniline to the component one solution, and mix well within 1 min. Use it to glue the intestinal tube and the edge of the membrane. After 3 minutes, check that there is no leakage at the anastomosis, return the intestinal tube to the abdominal cavity, and close the abdomen. Absorption and degradation were basically complete after 12 weeks. Tissue sections showed that the material had good biocompatibility.

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Abstract

The invention relates to a biodegradable active medical tissue adhesive and its preparation. The adhesive includes adhesives for bonding soft tissue, dental hard tissue, and orthopedic hard tissue, and its liquid phase is hydroxyethyl methacrylate ring-opening polymerized cyclic ester macromonomer, alcohol Biodegradable cross-linking agent with functional group as the central block, vinylpyrrolidone, N,N-dimethyl-p-toluidine, hydroquinone, etc.; solid phase is encapsulated natural bone powder, porogen, benzoyl peroxide, etc. . The preparation method includes mixing the liquid phase and the solid phase, and the obtained adhesive is easy to use and operate, has good biocompatibility of the material, and has adjustable mechanical strength and degradation rate.

Description

technical field [0001] The invention relates to a medical adhesive, in particular to a biodegradable active medical tissue adhesive and a preparation method thereof. Background technique [0002] Human organs or tissues often lose their original functions due to injury or defect caused by trauma, inflammation, tumor, congenital malformation or surgery. Therefore, the research and development of medical adhesives suitable for various tissue repairs has become a global issue and is a very active field in biomaterials research. Existing medical adhesives can be divided into two categories, one is soft tissue adhesives, mainly α-hydroxyacrylate fast adhesives and fibrin adhesives; the other is hard tissue adhesives , mainly traditional methyl methacrylate-based bone cement and activated phosphate-based bone cement. [0003] Two kinds of soft tissue adhesives, a-hydroxyacrylate fast adhesive and fibrin adhesive, are widely used clinically, and have the advantages of fast adhesi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L24/04A61K6/083
Inventor 周长忍杨媛罗丙红
Owner 广州暨科拓源生物材料科技开发有限公司
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