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NMR contrast agent and preparation method thereof

A nuclear magnetic resonance imaging and contrast agent technology, which is applied in the direction of nuclear magnetic resonance/magnetic resonance imaging contrast agent, etc., can solve the problems of not easy to externally modify groups or targeting reagents, limiting the application of carbon-coated nanomaterials, and unfavorable practical applications.

Inactive Publication Date: 2009-11-18
XIAMEN UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The resulting problem is that the surface of carbon-coated nanoparticles has strong hydrophobicity, which is not conducive to practical applications, and because of the high chemical stability of carbon, it is not easy to add external modification groups or targeting reagents, thus limiting the ability of carbon Application of Encapsulated Nanomaterials

Method used

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  • NMR contrast agent and preparation method thereof
  • NMR contrast agent and preparation method thereof
  • NMR contrast agent and preparation method thereof

Examples

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Embodiment 1

[0017] Example 1: at room temperature, 40 mg of ferric nitrate as an iron source is dissolved in 10 ml ethanol to form a solution with a mass percentage of 0.5%; 45 mg of decachloropyrene as a carbon source is dissolved in 1 ml toluene to form a mass percentage of 5% solution. Use ammonia water to adjust the pH value of the ethanol solution of ferric nitrate to 8, then mix it with the toluene solution of decachloropyrene, and dilute to 25ml with water. Pour the mixed solution into a polytetrafluoroethylene reactor and seal it in a stainless steel reactor. The reactor was heated to 200°C and kept for 48h. After cooling, the solution in the reactor is poured out, the insolubles are collected, washed and dried to obtain nanoscale carbon-coated iron oxide particles (such as figure 1 ). figure 2 It is the X-ray diffraction spectrum figure of product, proves that product is ferric oxide; Figure 4 is the Raman spectrum of the product, which proves that the carbon shell is compo...

Embodiment 2

[0018] Example 2: 40 mg of ferric sulfate as an iron source was dissolved in 5 ml of methanol to form a solution of 2.5% by mass; 225 mg of hexachlorobenzene as a carbon source was dissolved in 2 ml of benzene to form a solution of 2% by mass; Adjust the pH value of the iron source solution to 10, and react at 250° C. for 24 hours. All the other are with embodiment 1, product result is with embodiment 1.

Embodiment 3

[0019] Embodiment 3: Similar to Embodiment 1. The difference is that 40 mg of ferric chloride as an iron source is dissolved in 1 ml of propanol to form a solution of 5% by mass; 450 mg of hexabromobenzene as a carbon source is dissolved in 10 ml of xylene to form a 5% solution by mass solution; adjust the pH of the iron source solution to 12. Heated to 100°C and kept for 72h. Product result is with embodiment 1.

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Abstract

A nuclear magnetic resonance imaging contrast agent and a preparation method thereof, relating to a carbon-coated nano-iron oxide with surface modification, which is used as a nuclear magnetic resonance imaging contrast agent. Composed of nano-iron oxide, carbon and amine groups, its structure is nano-iron oxide particles as the core, surrounded by a carbon shell, and the carbon layer is connected to amine groups. The iron source and the carbon source are mixed in a molar ratio of 1:1-10, sealed and reacted at 120-250° C. for 12-72 hours to obtain nanoscale carbon-coated iron oxide particles. By wrapping the carbon layer around the nano-iron oxide particles, the chemical stability of the product is enhanced, and the product can exist stably in 1M hydrochloric acid solution for more than four months, which can effectively avoid iron ion poisoning; and simultaneously introduce surface modification groups Agglomerates, so that the Zeta potential value of the product in weakly acidic and neutral environments is below -30mV, the hydrophilicity of the product surface is improved and it is not easy to aggregate, which solves the main factor limiting its application; the NMR response signal is strong.

Description

technical field [0001] The invention relates to a contrast agent, in particular to a surface-modified carbon-coated nano-iron oxide, which is mainly used as a contrast agent for nuclear magnetic resonance imaging. Background technique [0002] The contrast agents currently used in MRI can be divided into two types in terms of chemical composition: transition metal complexes and magnetic iron oxide nanoparticles. The transition metal complex type is mainly gadolinium complex type. Magnetic iron oxide nanoparticles have attracted wide attention in recent years because of their low chemical toxicity, low clinical dose and potential for magnetic resonance target imaging. However, the biotoxicity research of iron oxide nanoparticles is not comprehensive enough, and it is necessary to avoid the aggregation of nanoparticles during use or storage. A general solution is to use biocompatible macromolecules or polymers (such as starch and dextran), wrap the nanoparticles in the cente...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K49/06
Inventor 翁建王晓峰张其清
Owner XIAMEN UNIV
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