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Medicament sustained-release carrier for eyes with cooperation treatment function

A technology of slow-release carrier and therapeutic effect, which is applied in the field of slow-release carrier of ophthalmic drugs, which can solve the problems of many impurities and wide molecular weight distribution, and achieve good therapeutic effect, inhibition of new blood vessels, and good suppression and prevention effect

Inactive Publication Date: 2010-03-24
SHANDONG EYE INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In addition, Bletilla striata (Bletilla striata) is the dried tuber of the orchid plant Bletilla striata. Commercial bletilla striata gum is a mucopolysaccharide extracted from Bletilla striata, but it has many impurities and a wide molecular weight distribution, so it is limited to oral or external use.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Extraction of Bletilla striata gum: extract and purify the bletilla striata gum required by the present invention with the following process.

[0021] The preparation of the refined bletilla striata gum required by the present invention comprises following two major steps:

[0022] 1. Crude polysaccharide extraction

[0023] Grind, sieve, and dry the dried bletilla striata tuber products, add 20 times the volume of distilled water, and extract under reflux at 60°C for 4 hours. Repeat the extraction once. Combine the two extracts. Centrifuge (5000×g, 10min), take the supernatant, concentrate under reduced pressure at 70°C, add three volumes of 95% ethanol to precipitate. The precipitate was collected by centrifugation and freeze-dried to obtain crude bletilla striata gum, which is common commercialized bletilla striata gum.

[0024] 2. Separation and purification

[0025] (1) Dissolve common commercial bletilla striata gum in the smallest volume of water, deproteini...

Embodiment 2

[0028] Select the bletilla striata gum prepared in Example 1 to prepare a 12% bletilla striata gum aqueous solution, take 20.0 ml of the bletilla striata gum aqueous solution in a sterile glass bottle, add 20.0 mg of ethylene glycol bisglycidyl ether, stir evenly, and place in a water bath at 55°C for 3 After ~5 hours, fully wash with water for injection to remove unreacted ethylene glycol bisglycidyl ether. Take it out, pour the cross-linked glue solution into a polytetrafluoroethylene mold, and place it in an oven at 40°C to dry to form a film. After the diaphragm is fully dried, take it out and put it in normal saline for injection to fully soak and wash it, take out the diaphragm, and after it is completely dry, a sheet with a thickness of 1.5-2 mm can be obtained, which can be cut into different shapes and sizes according to needs .

Embodiment 3

[0030] In Example 1, ethylene glycol diglycidyl ether is replaced with propylene glycol diglycidyl ether, and the rest of the conditions are unchanged, and the same crosslinking effect can also be obtained.

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PUM

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Abstract

The invention discloses an ophthalmic medicine slowly-releasing carrier with synergetic effect, which is characterized in that the medicine slowly-releasing carrier is bletilla striata gum, the main component of the bletilla striata gum is glucomannan which is polymerized by mannose and glucose at the ratio of 1 to 4; the average molecular weight is from 65000 to 150000, preferentially 100000. bletilla striata gum is accounted as glucomannan with a content being more than 85percent. Cross-linking agent which fulfills the effect of solidification is also added in the bletilla striata gum at theweight ratio of 100 to 0.01-20. The cross-linking agent is formaldehyde, glutaraldehyde, glycol diglycidyl ether, propanediol diglycidyl ether, or butanediol diglycidyl ether. Albumin, gelatin, or gum acacia are also added in the bletilla striata gum. The ophthalmic medicine slowly-releasing carrier of the invention not only can release the medicine slowly, but also has activity for clinically protecting the damaged tissue, preventing tumour, resisting oxidation, inhibiting neovascularization, etc, and has certain synergetic treatment effect on the medicine being carried with better curativeeffect.

Description

technical field [0001] The invention relates to a long-acting drug slow-release carrier for intraocular implantation, in particular to an ophthalmic drug slow-release carrier with synergistic therapeutic effect. Background technique [0002] Currently commonly used ophthalmic implant carriers such as collagen, chitosan (chitin), PGA (polyglycolic acid), PLA (polylactic acid), EVA (polyethylene acetate) and their copolymers PLGA (glycolic acid) Copolymer with lactic acid), PGLC (glycolide-lactide-caprolactone ternary random copolymer), etc., are only a kind of carrier and have no therapeutic effect. In recent years, ophthalmic sustained-release pharmaceutical preparations prepared using biodegradable materials as carriers have made it possible to prevent and treat some refractory diseases in ophthalmology, so they have been highly valued by scholars from all over the world. If a new type of carrier can be used, this carrier not only plays the role of slow release of drugs, b...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/36A61P27/02C08B37/00
Inventor 吴祥根史伟云谢立信
Owner SHANDONG EYE INST
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