Anticoagulant polyurethane material, and preparation and usage thereof

A polyurethane material and anti-coagulation technology, applied in anti-coagulation treatment, transportation and packaging, types of packaging items, etc., can solve the problems of endangering patient safety, unsatisfactory anti-coagulation performance, etc., to eliminate thrombosis, Solve blood compatibility problems, low cost effect

Inactive Publication Date: 2007-08-08
WUHAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, a large number of studies have shown that most polymer materials will cause different degrees of coagulation when they come into contact with blood, which will endanger the safety of patients in severe cases.
Polyurethane (PU) material is one of the most widely researched and applied biomedical polymer materials. It has excellent wear resistance, flex resistance, soft touch, moisture resistance and resistance to various chemicals. In addition, it is easy to process , can be sterilized by conventional methods, so it has great application value in various medical environments, especially in the manufacture of various medical supplies implanted in the human body, such as artificial heart valves, artificial blood vessels, etc., but the anticoagulant properties of traditional PU materials The performance is still unsatisfactory, so people need to work hard to solve the problem of blood compatibility of PU materials

Method used

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  • Anticoagulant polyurethane material, and preparation and usage thereof

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Experimental program
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preparation example Construction

[0024] 2. Preparation method of anticoagulant polyurethane material

[0025] 1. Preparation:

[0026] Through chemical modification method, first graft polyethylene glycol flexible spacer with active groups on the surface of the base layer in a covalent way to make it have anticoagulant function; then use the functional groups on polyethylene glycol and DSC The reaction is carried out to generate a lively reactive group NHS, and then the biologically active substance lysine is grafted on the surface of the NHS to activate the fibrinolytic pathway, so that it has the function of dissolving thrombus, thereby forming a modified layer. The base layer is made of common commercial polyurethane material or synthetic polyurethane material. The base layer and finishing layer constitute an anti-clotting polyurethane material.

[0027] See Figure 1, the specific steps include: functionalization of PU material with MDI, surface grafting of PEG, introduction of NHS active reactive groups...

Embodiment 1

[0042] First, dissolve the purified granular commercial polyurethane material (product of Shanghai Pengbosheng Polyurethane Co., Ltd.) in N, N-dimethylformamide (DMF), pour it into a flat-bottomed mold, and vacuum dry it after the solvent evaporates. To obtain the PU film, cut the PU film into small pieces with a diameter of 10 mm and a thickness of 0.5 mm, put it into a toluene solution of 5% MDI by mass ratio, stir and heat to 50 ° C, and then pass through N 2 Protection, triethylamine (TEA) according to mass ratio M TEA / M Toluene =2.5% was added to the reaction system, and the reaction was started after mixing evenly. After 60 minutes, it was washed several times with dry toluene. Put the above-mentioned functionalized PU film into the toluene solution of polyethylene glycol with a mass ratio of 10%, add 2 drops of dibutyloctyltin laurate as a catalyst, heat to 40°C for reaction under stirring, and use it after 24 hours Wash with distilled water several times, then soak ...

Embodiment 2

[0044] Add a magnet in the there-necked flask, weigh 5 grams of polytetrahydrofuran ether glycol (molecular weight is 1000), 5 grams of toluene, and measure 25 mL of DMF, then heat it to 110 ° C with a constant temperature magnetic stirrer and keep it warm for 1 hour. Parts were removed as a toluene azeotrope. Then, its temperature is controlled at 60°C to 65°C, and 3 drops (0.05wt%) of catalyst dibutyltin dilaurate are added dropwise to the there-necked flask with a dropper, and then the weighed 4.0 grams of MDI and the measured 25mL of DMF mixed solution was added into the reaction three-neck flask, and the temperature was controlled at this temperature range for 1.5 hours. Then slowly add 0.9 g of chain extender 1,4-butanediol into the three-necked flask with a dropper, raise the temperature to 80-85° C., and control the temperature to react for 3.5 hours. Then pour the reaction solution in the three-neck bottle into the prepared large beaker filled with distilled water al...

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Abstract

The invention relates to an anticoagulant polyurethane material formed by a decorate layer and a base layer, wherein, the base layer is formed by general commercial polyurethane material or composite polyurethane material, and the decorate layer is formed by chemically decorating the face of base layer. The decorate layer contains the PEG flexible distant group connected with the polyurethane base via covalence key and the active lycine lead by the NHS via surface grafting and the function group covalence key at the end of PEG. The inventive preparation comprises that using MDI to function the PU material, surface grafting the PEG, leading in NHS active reaction group, grafting lycine, and de-protecting theepsilon-NH2 of lycine. The invention has better anticoagulant and plug-dissolving functions, to eliminate the blood plug.

Description

technical field [0001] The invention relates to the fields of biomedical functional polymer materials and polymer chemistry, in particular to an anticoagulant polyurethane material with the function of dissolving thrombus and its preparation and application. Background technique [0002] With the rapid development and interpenetration of polymer science, medicine and biology, biomedical functional polymers have become one of the most extensively researched and most promising functional polymer materials. A large number of new medical materials and artificial devices made of polymer materials have appeared in the medical field, and they have played a huge role in safeguarding human health and promoting the development of human civilization. As a medical polymer used in vivo, it is inevitable to contact with blood, so the blood compatibility of materials is a problem that cannot be ignored in the application of medical materials. However, a large number of studies have shown ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/06A61L33/06A61L33/04A61L33/14
Inventor 陈红胡小洋王艺峰吴仲岿
Owner WUHAN UNIV OF TECH
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