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Antibacterial type blended electro spinning nanometer fiber membrane biological dressing and the preparing method thereof

A technology of nanofiber membrane and biological dressing, applied in fiber processing, fiber chemical characteristics, filament/thread forming, etc., can solve the problems of fiber roughness, wound secondary infection, fast drug release, etc., and achieve human affinity Antibacterial, prevent secondary infection, and accelerate wound healing

Inactive Publication Date: 2007-10-31
BEIJING UNIV OF CHEM TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The patent of publication number CN1640913 discloses a kind of preparation method of cross-linked chitosan-quaternized hydrolyzed collagen, the biological dressing that this method makes has antibacterial property, good advantage of gas permeability, but its strength is low; Publication number CN1579559A The patent discloses a polyvinyl alcohol hydrogel dressing containing drugs and chitosan and its preparation method. The dressing prepared by this method has active antibacterial ability, high water content and good air permeability, but its mechanical strength is low In addition, this method uses Coγ-rays or high-energy electron beam radiation crosslinking, which has the disadvantages of high cost, high risk, and easy damage to the molecular structure of chitosan, polyvinyl alcohol and drugs.
[0006] Non-woven dressings, such as the patent of Publication No. CN1493364A discloses a manufacturing method of chitosan biological dressing, the method is to make chitosan into silk, and then weaving into gauze, the dressing prepared by this method has good air permeability advantages, but it can not solve the problem of poor mechanical properties of chitosan itself; the patent publication number CN1115254A discloses a chitosan, collagen and calcium alginate biocomposite non-woven fabric dressing, the method is to put the non-woven fabric successively Immersed in chitosan-collagen solution and calcium alginate solution respectively, the dressing prepared by this method has the characteristics of biocompatibility and permeability, but its active substances are only attached to the surface of the non-woven fabric, and the drug release speed is fast. No slow-release function, short antibacterial time, easy to cause secondary infection of the wound
[0007] Wet-spun dressings, such as the patent of Publication No. CN1470679 disclose a chitin non-woven fabric and its production method, which has the advantages of good moisturizing and breathable effects and good biocompatibility, but its mechanical properties are relatively poor
The patent of publication number CN1687499 discloses sodium alginate / water-soluble chitin blended fiber and its preparation method and application, and the patent of publication number CN1699647 discloses chitosan and hydroxypropyl cellulose blended fiber and its preparation method and application. The dressings prepared by the two kinds of wet spinning dressings have good water absorption performance, but they will adhere to the wound due to blood coagulation, and because the fibers are rough, they cannot be compatible with tissues and cannot be absorbed by tissues, which is easy to cause damage when changing dressings. Wound neonatal tissue is damaged, which prolongs wound healing time and brings pain to patients

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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  • Antibacterial type blended electro spinning nanometer fiber membrane biological dressing and the preparing method thereof
  • Antibacterial type blended electro spinning nanometer fiber membrane biological dressing and the preparing method thereof
  • Antibacterial type blended electro spinning nanometer fiber membrane biological dressing and the preparing method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] A. Preparation of chitosan solution: at room temperature, the viscosity average relative molecular weight M n 120,000 chitosan was dissolved in a 90% acetic acid solution with a volume fraction of 7%, and stirred for 8 hours to obtain a translucent brown chitosan acetic acid solution;

[0030] B. Preparation of polyvinyl alcohol solution: Dissolve polyvinyl alcohol with a degree of polymerization of 3500 and a degree of alcoholysis of 88% in deionized water to prepare a solution with a mass fraction of 10%;

[0031] C. Mix the above chitosan solution and polyvinyl alcohol solution at a mass ratio of 5 / 1 to obtain a chitosan / polyvinyl alcohol complex solution;

[0032] D. Preparation of chitosan / polyvinyl alcohol / ofloxacin blend solution: grind ofloxacin into powder, and add 1 to the above chitosan / polyvinyl alcohol complex solution. % Ofloxacin, stir until completely dissolved;

[0033] E. Preparation of chitosan / polyvinyl alcohol / ofloxacin electrospun fiber membrane: the c...

Embodiment 2

[0035] A. Preparation of chitosan solution: same as in Example 1;

[0036] Preparation of B polyvinyl alcohol solution: the same as in Example 1;

[0037] C is the same as in Example 1;

[0038] D. Preparation of chitosan / polyvinyl alcohol / ofloxacin blending solution: preparation of chitosan / polyvinyl alcohol / ofloxacin blending solution: grinding ofloxacin into powder Add ofloxacin with a mass fraction of 2% to the polysaccharide / polyvinyl alcohol complex solution, and stir until it is completely dissolved;

[0039] E Preparation of chitosan / polyvinyl alcohol / ofloxacin electrospun fiber membrane: the same as in Example 1.

Embodiment 3

[0041] A. Preparation of chitosan solution: same as in Example 1;

[0042] Preparation of B polyvinyl alcohol solution: the same as in Example 1;

[0043] C is the same as in Example 1;

[0044] D. Preparation of chitosan / polyvinyl alcohol / ofloxacin blending solution: preparation of chitosan / polyvinyl alcohol / ofloxacin blending solution: grinding ofloxacin into powder Add 3% ofloxacin to the polysaccharide / polyvinyl alcohol complex solution, and stir until it is completely dissolved;

[0045] E Preparation of chitosan / polyvinyl alcohol / ofloxacin electrospun fiber membrane: the same as in Example 1;

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Abstract

The invention discloses a blending electric spun nanometer fiber film biological compress and preparing method in medicinal biological compress technical domain, which is characterized by the following: choosing chitose or polyvinyl alcohol or water-soluble antibacterial drugs as main raw material; adopting electrostatic spinning method; producing nanometer fiber film. This product possesses the advantages of higher strength, good air perviousness and good biological compatibility.

Description

Technical field: [0001] The invention relates to a blended electrospun nanofiber membrane biological dressing with antibacterial properties and a preparation method thereof, and belongs to the technical field of medical biological dressings. Background technique: [0002] Chitosan (Chitosan, CS) is a rich natural alkaline polysaccharide. It is the second largest biological resource after cellulose in nature. It has good biocompatibility, biodegradability, human compatibility and Excellent properties such as antibacterial, hemostasis and promotion of wound healing, it can be absorbed by itself after use, does not cause allergies, can also accelerate wound healing, has a protective effect on large-area burns, and can promote skin regeneration; the medical non-woven fabric produced by it can be used Used on burn wounds and skin supply areas, it not only plays a role in covering and protecting the wound, but also has low antigenicity. Therefore, chitosan biological dressings have rec...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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Application Information

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IPC IPC(8): A61L15/28A61L15/44D01F9/00D01D5/00
Inventor 聂俊甄洪鹏杨冬芝周应山
Owner BEIJING UNIV OF CHEM TECH
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