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Anti-coagulation stainless steel coronary arterial bracket and uses thereof

A stainless steel, anti-coagulation technology, applied in the field of medical devices, can solve the problems of increasing stent restenosis, aggravating inflammatory response, etc., and achieve the effects of good flexibility, high plasticity and toughness, and good biological compatibility

Active Publication Date: 2010-12-08
ZHONGKE YIAN MEDICAL TECH BEIJING CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Studies have shown that contact allergy caused by the release of nickel ions in stainless steel stents will aggravate the inflammatory response and stimulate the proliferation of new tissue around the stent, thus increasing the possibility of stent restenosis

Method used

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  • Anti-coagulation stainless steel coronary arterial bracket and uses thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] High-nitrogen nickel-free stainless steel HNS1 (see Table 1) was used to make coronary stent samples (after polishing, the average wire diameter was 70 μm ± 5 μm), ultrasonically cleaned in acetone and alcohol for 5 minutes, and passivated in concentrated nitric acid for 30 minutes , and then kept in an oven at 80°C for 6 hours. Then put the stent into a drug-containing solution in tetrahydrofuran (containing 0.1% paclitaxel) with a mass concentration of 1% polymethyl methacrylate, soak for 30 minutes, quickly lift the stent, and centrifuge at 500rpm for 1 minute After carefully cleaning the coating on the inner surface of the stent, evenly coat the inner surface with a solution containing 20% ​​mass concentration of endothelial growth factor (VEGF), then put it in a vacuum drying oven at 90°C for 30 minutes, and cool to room temperature with the furnace .

Embodiment 2

[0034] High-nitrogen nickel-free stainless steel HNS2 (see Table 1) was used to make coronary stent samples (after polishing, the average wire diameter was 55 μm ± 5 μm), ultrasonically cleaned in acetone and alcohol for 5 minutes, and passivated in concentrated nitric acid for 30 minutes , and then kept in a 70°C drying oven for 8 hours. Then put the stent in the spraying device, and use the spray gun to spray the colloid containing medicaments in tetrahydrofuran (containing 0.05% rapamycin) with a mass concentration of 0.8% polytetrafluoroethylene to the outer surface of the stent several times, and the inner The surface was protected with a built-in core, and then a solution containing 30% endothelial growth factor (VEGF) was uniformly coated on the inner surface, and finally the scaffold was dried in a vacuum oven at 60°C for 12 hours.

Embodiment 3

[0036] High-nitrogen nickel-free stainless steel HNS3 (see Table 1) was used to make coronary stent samples (after polishing, the average wire diameter was 45 μm ± 5 μm), ultrasonically cleaned in acetone and alcohol for 5 minutes, and passivated in concentrated nitric acid for 30 minutes , and then kept in a 100°C drying oven for 5 hours. Then put the stent in the spraying device, use the spray gun to spray the colloid containing medicaments in tetrahydrofuran (containing 0.08% heparin) with a mass concentration of 3% polyglycolide to the outer surface of the stent several times, and the inner surface is sprayed with a built-in Then, the inner surface was uniformly coated with a solution containing 40% endothelial growth factor (VEGF), and finally the scaffold was dried in a vacuum oven at 50°C for 20 hours.

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Abstract

The invention relates to a medical apparatus, in particular to an anticoagulant stainless steel coronary support which is made from a high-nitrogen nickel-free austenitic stainless steel material with good blood compatibility. The support is of tubular structure with a mesh surface which is formed by orderly arranging a unit figure on the side surface of a tube along the circumference and axial direction, the primary supporting function is provided by U-shaped corrugated mesh wires extending along the axial direction, the corrugated mesh wires are connected into a whole body by soft mesh wires arranged at intervals, and the diameter of the mesh wire (width or thickness) is 40-100mum; and the surface of the support is passivated and coated with a medication. The anticoagulant stainless steel support has the advantages of good mechanical properties, good flexibility and good anticoagulant property, and can be used as a support for cardiovascular and cerebrovascular systems or a support for other cavity bodies.

Description

technical field [0001] The invention relates to a medical device, in particular to an anticoagulant high-nitrogen nickel-free stainless steel coronary artery stent and its application. Background technique [0002] With the development of modern medical technology and the improvement of medical equipment, coronary artery stent implantation has gradually become a major means of interventional cardiovascular therapy. At present, there are more than 25 million patients with coronary heart disease in my country, and they are in a period of rapid growth. With the aging population, changes in diet structure and accelerated pace of life, the incidence of coronary heart disease in my country will continue to increase. Therefore, it can be predicted that my country is the most potential coronary stent market. However, the current clinical application of coronary stents is still restricted by problems such as postoperative restenosis. In-stent restenosis is mainly caused by thrombu...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61F2/82A61L27/04A61L27/36A61L27/50
Inventor 任伊宾杨柯张炳春肖克沈杨慧宾郑丰
Owner ZHONGKE YIAN MEDICAL TECH BEIJING CO LTD
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