Preparation method of anti-hemorrhoid extract containing rutin and naringin

Abstract

The invention discloses an anti-hemorrhoidal extract and a preparation method thereof. The extract is extracted from bud of Chinese scholartree, flower of Japanese pagoda tree or fruit of citron or trifoliate orange, and contains 55-90% of total flavonoids; wherein, the content ratio of rutin to naringin by percentage is 0.8-4:1. An industrialized process for preparing the extract is preferably achieved by taking medicinal materials such as the bud of Chinese scholartree and the fruit of citron or trifoliate orange as sources according to the process for preparing macroporous resin and water boiling and alcohol precipitation method. The selected process for preparing the macroporous resin has the advantages of being simple and convenient, having good reproductivity, effectively concentrating flavonoid ingredients, getting rid of non-flavonoid ingredients such as triterpenoids, steroids and the like, producing the product with readily controlled quality and high content, extracting at a high efficiency, being usable for industrialized production and the like. The invention also provides a pharmaceutical composition containing the anti-hemorrhoidal total flavonoid extract. The anti-hemorrhoidal total flavonoid extract has good therapeutic effects on diseases such as hemorrhoid, various inflammations and the like.

Description

technical field [0001] The invention relates to a preparation method of an anti-hemorrhoid extract containing rutin and naringin. Background technique [0002] Hemorrhoids are a common and frequently-occurring disease. There has been a saying in China that "nine out of ten people have hemorrhoids" since ancient times. Chinese Patent Application No. 200710124647.5, entitled "An Anti-Hemorrhoid Pharmaceutical Composition", discloses an anti-hemorrhoid composition containing rutin and naringin in a weight percentage of 0.8-4:1, which has a significant anti-hemorrhoid effect. And specifically disclosed two preparation methods, one is directly mixing rutin and naringin; the other is direct water extraction or aqueous ethanol extraction, that is, select the medicinal materials Citrus aurantium and Sophora japonica (or Sophora japonica), add water to decoct, Collect the extract, concentrate the extract, dry, and collect to obtain the Chinese medicine extract; or take the Chinese m...

AI Technical Summary

Problems solved by technology

The rutin and naringin used in the direct mixing method are all pure products. The preparation process and purification of these two pure products through traditional Chinese medicine extraction are very complicated, the purification route is cumbersome, and the cost is very high; the cost of synthesis through western medicine is also very high. Large, the cost of preparing the anti-hemorrhoid composition will be relatively high

The composition prepared by direct water extraction or aqueous ethanol extraction will contain more other water-soluble components, such as protein, sugar, amino acid, etc., and some alkaloid components such as synephrine (can Excite a receptor, make blood pressure rise, and can strengthen the heart, anti-shock) and N-methyltyramine etc., these alkaloid components are non-flavonoids, non-anti-hemorrhoid components, will affect the anti-hemorrhoid composition purity

Also because there are many water-soluble components, the sample is sticky paste, the operation of concentration and drying is extremely troublesome, the loss of active ingredients is large during the transfer process, and the repeatability is not good. mildew

At the same time, since the original crude extract is an extract, there are many other impurities in the sample, the pretreatment before sample analysis is more complicated, and there are many dilution and transfer steps, resulting in cumbersome direct analysis methods

[0003] In addition, the applicant also adopted the conventional preparation process of macroporous resin, and prepared from any process parameters such as extraction of medicinal materials, sample loading, elution of ethanol concentration, drying, etc., and found that the prepared products were difficult to meet the requirements disclosed in the patent application number 200710124647.5 Contains rutin and naringin in a certain weight percentage of 0.8-4:1, and the product properties, viscosity, and hygroscopicity are too strong, high in sugar content, and non-flavonoids and alkaloids are difficult to remove

And preservation, preparation processing is very inconvenient

Images